Title:
AMIDE COMPOUND, AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/037520
Kind Code:
A1
Abstract:
Disclosed in the present invention are a new compound as represented by general formula I, a pharmaceutically acceptable salt, an enantiomer, a diastereoisomer and a racemate thereof, and a pharmaceutical composition containing the compound. Rings R1, R2, R3, R4, R4'A, etc., have meanings as shown in the specification. The present invention also relates to a method for preparing the compounds, and further relates to the use of the compounds, pharmaceutically acceptable salts, solvates and stereoisomers including the mixtures in various proportions thereof, in particular to the use of the compounds in the preparation of antiviral drugs.
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Inventors:
LIU HONG (CN)
LI JIAN (CN)
SUN JINA (CN)
DAI WENHAO (CN)
XIE XIONG (CN)
HU SHULEI (CN)
JIANG HUALIANG (CN)
CHEN KAIXIAN (CN)
LI JIAN (CN)
SUN JINA (CN)
DAI WENHAO (CN)
XIE XIONG (CN)
HU SHULEI (CN)
JIANG HUALIANG (CN)
CHEN KAIXIAN (CN)
Application Number:
PCT/CN2023/113026
Publication Date:
February 22, 2024
Filing Date:
August 15, 2023
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07D209/40; A61K31/277; A61K31/40; A61K31/404; A61K31/44; A61K31/454; A61K31/4545; A61K31/4709; A61K31/505; A61K31/506; A61K31/513; A61K31/517; A61K38/07; A61P31/14; C07C229/18; C07D211/76; C07D213/65; C07D213/74; C07D239/42; C07D239/545; C07D239/94; C07D401/12; C07D401/14; C07D403/04; C07D403/12; C07D403/14; C07D409/14; C07K5/078
Domestic Patent References:
| WO2002069901A2 | 2002-09-12 | |||
| WO2000049007A1 | 2000-08-24 | |||
| WO2007121124A2 | 2007-10-25 |
Foreign References:
| CN102405211A | 2012-04-04 | |||
| CN106928206A | 2017-07-07 | |||
| CN113620929A | 2021-11-09 | |||
| CN115466225A | 2022-12-13 | |||
| CN1362947A | 2002-08-07 |
Other References:
DATABASE Registry 26 September 2021 (2021-09-26), ANONYMOUS : " 2-Pyrrolidinecarboxamide, 1-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-N- (cyanomethyl)- (CA INDEX NAME)", XP093140691, retrieved from STNext Database accession no. 2700465-97-8
WANG XIAO-YU, CHENG PENG, YAN-QING YANG, SHI YU-LONG, ZHENG-DAN ZHU, KAI-JIE M U, LI HUI-YU, XU ZHI-JIAN, ZHU WEI-LIANG: "Research progress on active compounds against pathogenic coronaviruses and their potential target proteins", ACTA PHARMACEUTICA SINICA, vol. 55, no. 10, 20 June 2020 (2020-06-20), pages 2340 - 2357, XP093139554, DOI: 10.16438/j.0513-4870.2020-0579
CHOWDHURY SANDIPAN ROY; KENNEDY STEVEN; ZHU KAI; MISHRA RAMA; CHUONG PATRICK; NGUYEN ALYSSA-UYEN; KATHMAN STEFAN G.; STATSYUK ALEX: "Discovery of covalent enzyme inhibitors using virtual docking of covalent fragments", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 29, no. 1, 1 January 1900 (1900-01-01), Amsterdam NL , pages 36 - 39, XP085557013, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2018.11.019
WANG XIAO-YU, CHENG PENG, YAN-QING YANG, SHI YU-LONG, ZHENG-DAN ZHU, KAI-JIE M U, LI HUI-YU, XU ZHI-JIAN, ZHU WEI-LIANG: "Research progress on active compounds against pathogenic coronaviruses and their potential target proteins", ACTA PHARMACEUTICA SINICA, vol. 55, no. 10, 20 June 2020 (2020-06-20), pages 2340 - 2357, XP093139554, DOI: 10.16438/j.0513-4870.2020-0579
CHOWDHURY SANDIPAN ROY; KENNEDY STEVEN; ZHU KAI; MISHRA RAMA; CHUONG PATRICK; NGUYEN ALYSSA-UYEN; KATHMAN STEFAN G.; STATSYUK ALEX: "Discovery of covalent enzyme inhibitors using virtual docking of covalent fragments", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 29, no. 1, 1 January 1900 (1900-01-01), Amsterdam NL , pages 36 - 39, XP085557013, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2018.11.019
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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