Title:
AMIDE COMPOUNDS AND USE OF THE SAME
Document Type and Number:
WIPO Patent Application WO/1997/008133
Kind Code:
A1
Abstract:
Amide compounds represented by general formula (I), pharmaceutically acceptable acid-addition salts thereof and a drug comprising the same as the active ingredient, wherein R represents amino, etc.; A represents alkylene, etc.; X represents O, S, etc.; M represents arylene, etc.; R1, R2, R3 and R4 represent each H, hydroxy, etc.; R5 represents H, alkyl, etc.; m is an integer of from 0 to 6; R6 represents optionally substituted aryl, etc.; and R7 represents H, optionally substituted alkyl, etc. The amide compounds exhibit excellent inhibitory effects on cytokines (IL-8, IL-1, IL-6, TNF- g(a), GM-CSF, etc.) relating directly or indirectly to inflammation and are useful in the prevention or treatment of arthritis caused by rheumatic diseases, gout, etc.
Inventors:
HARUTA JUNICHI (JP)
SAKUMA KAZUHIKO (JP)
WATANABE YOSHIHIRO (JP)
SAKUMA KAZUHIKO (JP)
WATANABE YOSHIHIRO (JP)
Application Number:
PCT/JP1996/002305
Publication Date:
March 06, 1997
Filing Date:
August 15, 1996
Export Citation:
Assignee:
JAPAN TOBACCO INC (JP)
HARUTA JUNICHI (JP)
SAKUMA KAZUHIKO (JP)
WATANABE YOSHIHIRO (JP)
HARUTA JUNICHI (JP)
SAKUMA KAZUHIKO (JP)
WATANABE YOSHIHIRO (JP)
International Classes:
C07D295/08; A61K31/135; A61K31/16; A61K31/165; A61K31/166; A61K31/21; A61K31/215; A61K31/41; A61K31/42; A61K31/423; A61K31/4245; A61K31/435; A61K31/44; A61K31/445; A61K31/4465; A61K31/495; A61K31/496; A61K31/60; A61P1/04; A61P1/16; A61P9/00; A61P9/08; A61P11/00; A61P29/00; A61P37/06; A61P43/00; C07C65/03; C07C217/48; C07C235/60; C07C235/84; C07C237/20; C07C237/22; C07C237/36; C07C237/42; C07C237/44; C07C239/16; C07C251/66; C07C259/06; C07C259/18; C07C271/16; C07C279/08; C07C311/01; C07C311/15; C07C317/44; C07C323/62; C07C327/22; C07D211/22; C07D211/34; C07D211/46; C07D211/62; C07D213/75; C07D241/04; C07D263/58; C07D271/06; C07D295/088; C07D295/092; C07D295/10; C07D295/14; C07D295/15; C07K5/06; (IPC1-7): C07C235/60; A61K31/215; A61K31/445; A61K31/495; C07C279/08; C07D211/34; C07D241/04; C07D263/58; C07D271/06; C07D295/08; C07D295/10
Foreign References:
| JPS63238051A | 1988-10-04 | |||
| JPS63239256A | 1988-10-05 | |||
| JPS4818241A |
Other References:
See also references of EP 0849256A4
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