Title:
AMIDE DERIVATIVE HAVING ANTIVIRAL ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2022/092141
Kind Code:
A1
Abstract:
The present invention provides: a compound, or a pharmaceutically acceptable salt thereof, having an antiviral activity and represented by formula (I); and a pharmaceutical composition containing the same. (In the formula, the broken lines indicate the presence or absence of bonding; R1 is a carboxy or the like; L is a substituted or unsubstituted non-aromatic carbocyclic diyl or the like; R2 is a substituted or unsubstituted alkyl; R3 is a hydrogen atom or the like; X is =CRX− or =N−; Y is =CRY− or =N−; U is −CRU= or −N=; V is −CRV= or −N=; W is =CRW− or =N−; ZA is −C= or −N−; ZB is −CR5R6− or the like; ZC is −CR7R8− or the like; RX, RY, RV and RW are each independently a hydrogen atom or the like; RU is a hydrogen atom or the like; R5 and R6 are each independently a hydrogen atom or the like; R7 and R8 are each independently a hydrogen atom or the like; R4 is substituted or unsubstituted alkyloxy or the like.)
Inventors:
OKANO AZUSA (JP)
TATENO YUSUKE (JP)
NODU KOUHEI (JP)
SUZUKI SHINJI (JP)
AKIYAMA TOSHIYUKI (JP)
MATOYAMA MASAAKI (JP)
AKAZA HIROTO (JP)
FUKUDA TAKASHI (JP)
TATENO YUSUKE (JP)
NODU KOUHEI (JP)
SUZUKI SHINJI (JP)
AKIYAMA TOSHIYUKI (JP)
MATOYAMA MASAAKI (JP)
AKAZA HIROTO (JP)
FUKUDA TAKASHI (JP)
Application Number:
PCT/JP2021/039623
Publication Date:
May 05, 2022
Filing Date:
October 27, 2021
Export Citation:
Assignee:
SHIONOGI & CO (JP)
UBE INDUSTRIES (JP)
UBE INDUSTRIES (JP)
International Classes:
C07D209/18; A61K31/4045; A61K31/437; A61K31/4439; A61K31/444; A61K31/4545; A61K31/506; A61K31/5377; A61P31/14; C07D401/14; C07D403/04; C07D403/14; C07D405/12; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D471/04; C07D471/10; C07D487/04; C07D491/107; C07D491/20; C07D495/10; C07D519/00
Domestic Patent References:
| WO2016148145A1 | 2016-09-22 |
Foreign References:
| JP2015516976A | 2015-06-18 | |||
| JP2014509625A | 2014-04-21 | |||
| JP2009532417A | 2009-09-10 |
Other References:
PIRAS, SANDRA ET AL.: "Dichloro-phenyl-benzotriazoles: a new selective class of human respiratory syncytial virus entry inhibitors", FRONTIERS IN CHEMISTRY, vol. 7, no. 247, 16 April 2019 (2019-04-16), pages 1 - 18, XP002801793, DOI: 10.3389/fchem.2019.00247
CELLULAR AND MOLECULAR LIFE SCIENCES, 16 June 2020 (2020-06-16), pages 1 - 14
EXPERT OPINION ON INVESTIGATIONAL DRUGS, vol. 3, 29 March 2020 (2020-03-29), pages 285 - 294
"Labeled Compounds (Part A", vol. 1, 1987, article "Isotopes in the Physical and Biomedical Sciences"
"Design of Prodrugs", 1985, ELSEVIER
THEODORA W GREEN: "Protective Groups in Organic Synthesis", JOHN WILEY & SONS
CELLULAR AND MOLECULAR LIFE SCIENCES, 16 June 2020 (2020-06-16), pages 1 - 14
EXPERT OPINION ON INVESTIGATIONAL DRUGS, vol. 3, 29 March 2020 (2020-03-29), pages 285 - 294
"Labeled Compounds (Part A", vol. 1, 1987, article "Isotopes in the Physical and Biomedical Sciences"
"Design of Prodrugs", 1985, ELSEVIER
THEODORA W GREEN: "Protective Groups in Organic Synthesis", JOHN WILEY & SONS
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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