Title:
AMIDE DERIVATIVES AND DRUG COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO/2000/044743
Kind Code:
A1
Abstract:
Amide derivatives represented by general formula [1] or pharmaceutically acceptable salts thereof, and drug compositions containing both as the active ingredient: (wherein R?1¿ and R?2¿ are each independently hydrogen, optionally substituted alkyl, acyl, optionally substituted aryl, or an optionally substituted aromatic heterocyclic group; R?3¿, R?4¿, R?5¿ and R?6¿ are each independently hydrogen, halogeno, hydroxyl, optionally substituted amino, optionally substituted alkyl, alkoxy, nitro, or the like; and R?7¿ is optionally substituted cyclic amino or optionally substituted azabicycloalkylamino). The above compounds are useful as TGF-$g(b) production inhibitors or TGF-$g(b) antagonists.
Inventors:
TANIGUCHI NORIHISA (JP)
SHIROUCHI YOSHIAKI (JP)
SHIROUCHI YOSHIAKI (JP)
Application Number:
PCT/JP2000/000396
Publication Date:
August 03, 2000
Filing Date:
January 27, 2000
Export Citation:
Assignee:
NIPPON SHINYAKU CO LTD (JP)
TANIGUCHI NORIHISA (JP)
SHIROUCHI YOSHIAKI (JP)
TANIGUCHI NORIHISA (JP)
SHIROUCHI YOSHIAKI (JP)
International Classes:
A61P43/00; C07D401/12; C07D401/14; C07D403/14; C07D409/14; C07D417/14; C07D451/04; C07D491/04; (IPC1-7): C07D401/12; A61K31/46; A61K31/496; A61K31/551; A61P43/00; C07D401/14; C07D403/14; C07D405/14; C07D409/14; C07D417/14; C07D451/04
Domestic Patent References:
| WO1984000166A1 | 1984-01-19 |
Foreign References:
| JPH08333249A | 1996-12-17 |
Other References:
SCHAUS J.M. ET AL.: "Synthesis and structure-activity relationships of potent and orally active 5-HT4 receptor antagonists: Indazole and benzimidazolone Derivatives", J. MED. CHEM.,, vol. 41, no. 11, 1998, pages 1943 - 1955, XP002927642
ROMERO D.L. ET AL.: "Discovery synthesis, and bioactivity of bis(heteroaryl)piperazines..A novel class of non-nucleoside HIV-1 reverse transcriptase inhibitors", J. MED. CHEM.,, vol. 37, no. 7, 1994, pages 999 - 1014, XP002927643
See also references of EP 1156045A4
ROMERO D.L. ET AL.: "Discovery synthesis, and bioactivity of bis(heteroaryl)piperazines..A novel class of non-nucleoside HIV-1 reverse transcriptase inhibitors", J. MED. CHEM.,, vol. 37, no. 7, 1994, pages 999 - 1014, XP002927643
See also references of EP 1156045A4
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