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Title:
AMIDINE DERIVATIVE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/160509
Kind Code:
A1
Abstract:
Provided in the present invention are an amidine derivative compound as represented by formula I, and a preparation method therefor and the use thereof. The amidine derivative compound of the present invention has Nav1.8 selective inhibitory activity, can be used as a Nav1.8 selective inhibitor, has good pharmacokinetic properties, can be used for treating or relieving pain-related diseases, and has important clinical application value.

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Inventors:
GAO ZHAOBING (CN)
YANG CHUNHAO (CN)
TAN CUN (CN)
ZHENG YUEMING (CN)
FU LINSHU (CN)
XU HAIYAN (CN)
ZHANG XIAOFEI (CN)
CHEN XIAOYAN (CN)
HU YOUHONG (CN)
XIONG BING (CN)
HE QIAN (CN)
WEI AIHUAN (CN)
Application Number:
PCT/CN2023/077288
Publication Date:
August 31, 2023
Filing Date:
February 21, 2023
Export Citation:
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Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
A61K31/33; C07C257/18; A61P29/00; C07D213/16
Domestic Patent References:
WO2014120808A12014-08-07
WO2016029216A22016-02-25
WO2020146612A12020-07-16
Foreign References:
CN114437062A2022-05-06
CN112689633A2021-04-20
CN101883760A2010-11-10
CN112390745A2021-02-23
CN114031518A2022-02-11
US20150166589A12015-06-18
US20210139456A12021-05-13
US20220048892A12022-02-17
Other References:
DATABASE REGISTRY ANONYMOUS : "- Benzamide, N-[3-chloro-4-[(hydroxyamino)iminomethyl]phenyl]-2-phenoxy- (CA INDEX NAME)", XP093088577, retrieved from STN
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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