Title:
AMINATED COMPLEX-TYPE SUGAR CHAIN DERIVATIVES AND PROCESS FOR THE PRODUCTION THEREOF
Document Type and Number:
WIPO Patent Application WO/2005/010053
Kind Code:
A1
Abstract:
Aminated complex-type sugar chain derivatives represented by the general formula (1): wherein R1 is -NH-(CO)-CH2X, -NH-(CO)-(CH2)b-CH2X, isothio- cyanato, -NH-(CO)a-(CH2)b-CO2H, or -NH-(CO)a-(CH2)b-CHO; X is halogeno; a is 0 or 1; b is an integer of 1 to 4; and R2 and R3 are each independently hydrogen or a group represented by one of the general formulae (2) to (5), with the proviso that the case wherein both of R2 and R3 are each hydrogen or a group of the general formula (5) and the case wherein either of R2 and R3 is hydrogen and the other is a group of the general formula (5) are excluded.
Inventors:
KAJIHARA YASUHIRO (JP)
FUKAE KAZUHIRO (JP)
FUKAE KAZUHIRO (JP)
Application Number:
PCT/JP2004/011036
Publication Date:
February 03, 2005
Filing Date:
July 27, 2004
Export Citation:
Assignee:
KAJIHARA YASUHIRO (JP)
OTSUKA CHEMICAL CO LTD (JP)
FUKAE KAZUHIRO (JP)
OTSUKA CHEMICAL CO LTD (JP)
FUKAE KAZUHIRO (JP)
International Classes:
A61K47/48; C07H13/00; (IPC1-7): C08B37/00; C07K9/00; C07K16/00
Foreign References:
| JPH05222099A | 1993-08-31 | |||
| JPH0383993A | 1991-04-09 |
Other References:
TUZIKOV A.B. ET AL.: "Conversion of complex sialooligosaccharides into polymeric conjugates and their anti-fluenza virus inhibitory potency", JOURNAL OF CARBOHYDRATE CHEMISTRY, vol. 19, no. 9, 2000, pages 1191 - 1200, XP001002524
MANGER I.D. ET AL.: "Synthesis of 1-N-glycyl -oligosaccharide derivatives. Reactivity of lens culinaris lectin with a fluorescent labeled streptavidin pseudoglycoprotein and immobilized neoglycolipid", BIOCHEMISTRY, vol. 31, no. 44, 1992, pages 10733 - 10740, XP000560378
WONG S.Y.C. ET AL.: "Synthetic glycosylation of proteins using N-( -saccharide) iodoacetamides: applications in site-specific glycosylation and solid-phase enzymic olisaccharide synthesis", BIOCHEMICAL JOURNAL, vol. 300, no. 3, 1994, pages 843 - 50, XP009000756
See also references of EP 1650226A4
MANGER I.D. ET AL.: "Synthesis of 1-N-glycyl -oligosaccharide derivatives. Reactivity of lens culinaris lectin with a fluorescent labeled streptavidin pseudoglycoprotein and immobilized neoglycolipid", BIOCHEMISTRY, vol. 31, no. 44, 1992, pages 10733 - 10740, XP000560378
WONG S.Y.C. ET AL.: "Synthetic glycosylation of proteins using N-( -saccharide) iodoacetamides: applications in site-specific glycosylation and solid-phase enzymic olisaccharide synthesis", BIOCHEMICAL JOURNAL, vol. 300, no. 3, 1994, pages 843 - 50, XP009000756
See also references of EP 1650226A4
Attorney, Agent or Firm:
Tamura, Iwao (Terauchi 1-chome Toyonaka-shi, Osaka, JP)
Download PDF: