Title:
AMINE COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/094156
Kind Code:
A1
Abstract:
Provided is a compound represented by formula (I), or a stereoisomer thereof, an optical isomer thereof, a solvate thereof, an isotope derivative thereof, or a pharmaceutically acceptable salt thereof. The compound can be used as a ligand of a Sigma-1 receptor and/or an M1-muscarinic acetylcholine receptor. Such compounds and pharmaceutical compositions comprising same have the use of preparing a drug for treating and/or preventing a nervous system disease. Ring A, ring B, ring C, RC, L, R1, R2, and n in formula (I) are as defined in the specification.
Inventors:
WANG ZHENYU (CN)
HUA XINXING (CN)
HU JIMING (CN)
AN HUI (CN)
GAO JUN (CN)
LI ZIZHEN (CN)
TIAN JIAHUI (CN)
WANG KUANGLEI (CN)
WANG KEZHU (CN)
LIU XIBAO (CN)
HUA XINXING (CN)
HU JIMING (CN)
AN HUI (CN)
GAO JUN (CN)
LI ZIZHEN (CN)
TIAN JIAHUI (CN)
WANG KUANGLEI (CN)
WANG KEZHU (CN)
LIU XIBAO (CN)
Application Number:
PCT/CN2023/129527
Publication Date:
May 10, 2024
Filing Date:
November 03, 2023
Export Citation:
Assignee:
CSPC ZHONGQI PHARMACEUTICAL TECH SHIJIAZHUANG CO LTD (CN)
International Classes:
C07D413/06; A61K31/135; A61K31/341; A61K31/357; A61K31/397; A61K31/4025; A61K31/438; A61K31/443; A61K31/5377; A61P25/00; A61P25/28; C07C211/17; C07D407/06; C07D491/08; C07D491/107
Foreign References:
| CN102325529A | 2012-01-18 | |||
| CN101646430A | 2010-02-10 | |||
| CN106456578A | 2017-02-22 |
Other References:
FRANCHINI SILVIA; BATTISTI UMBERTO MARIA; PRANDI ADOLFO; TAIT ANNALISA; BORSARI CHIARA; CICHERO ELENA; FOSSA PAOLA; CILIA ANTONIO;: "Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 112, 1 February 2016 (2016-02-01), AMSTERDAM, NL , pages 1 - 19, XP029450395, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2016.01.059
LEHMANN, JOCHEN ET AL.: "Lactones, XII: Diarylierte Tetrahydrofurfurylamine aus γ–Aminomethyl-γ–butyrolactonen", ARCHIV DER PHARMAZIE, vol. 319, 31 December 1986 (1986-12-31), pages 664 - 666, XP000923122, DOI: 10.1002/ardp.19863190718
DATABASE REGISTRY 18 January 1986 (1986-01-18), ANONYMOUS: "- Piperidine, 1-[[5-(4-chlorophenyl)tetrahydro-5-phenyl-3-furanyl]methyl]- (CA INDEX NAME)", XP093166462, Database accession no. 99761-15-6
LEHMANN, JOCHEN ET AL.: "Lactones, XII: Diarylierte Tetrahydrofurfurylamine aus γ–Aminomethyl-γ–butyrolactonen", ARCHIV DER PHARMAZIE, vol. 319, 31 December 1986 (1986-12-31), pages 664 - 666, XP000923122, DOI: 10.1002/ardp.19863190718
DATABASE REGISTRY 18 January 1986 (1986-01-18), ANONYMOUS: "- Piperidine, 1-[[5-(4-chlorophenyl)tetrahydro-5-phenyl-3-furanyl]methyl]- (CA INDEX NAME)", XP093166462, Database accession no. 99761-15-6
Attorney, Agent or Firm:
INSIGHT INTELLECTUAL PROPERTY LIMITED (CN)
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