Title:
AMINO ACID ACTIVE ESTER AND SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/234425
Kind Code:
A1
Abstract:
The present invention provides a novel active ester of an amino acid to be used for amino acylation of tRNA, said ester being capable of reducing risks to safety and waste. The present invention provides a compound represented by formula (I) or a salt thereof, in particular, dichloropyridinyl methyl ester or 2,2,2-trifluoroethyl ester or a salt thereof.
Inventors:
MATSUDA AYUMU (JP)
CARY DOUGLAS ROBERT (JP)
MATSUI KATSUMA (JP)
BASHIRUDDIN NASIR KATO (JP)
MASUYA KEIICHI (JP)
CARY DOUGLAS ROBERT (JP)
MATSUI KATSUMA (JP)
BASHIRUDDIN NASIR KATO (JP)
MASUYA KEIICHI (JP)
Application Number:
PCT/JP2023/021439
Publication Date:
December 07, 2023
Filing Date:
June 02, 2023
Export Citation:
Assignee:
PEPTIDREAM INC (JP)
International Classes:
C07C229/08; C07C227/18; C07C231/02; C07C233/47; C07D209/18; C07D213/55; C07D213/61; C07D213/62; C07D213/74; C07D213/79; C07D215/12; C07D217/26; C07D231/56; C07D401/12; C07D405/12; C07D409/12; C07D413/12; C07D471/04; C07D495/04; C12N15/09; C40B40/10
Domestic Patent References:
| WO2017133517A1 | 2017-08-10 |
Foreign References:
| JPH11171864A | 1999-06-29 | |||
| US5534541A | 1996-07-09 | |||
| CN106467471A | 2017-03-01 | |||
| US20220144883A1 | 2022-05-12 | |||
| JPS58150547A | 1983-09-07 | |||
| JPH09208541A | 1997-08-12 |
Other References:
DATABASE REGISTRY 4 October 2021 (2021-10-04), ANONYMOUS : " 3-Isoxazolidinecarboxyli c acid, 5-(2,5-dimeth oxyphenyl)-, (3,6-dichloro-2-pyrid inyl)methyl ester (CA INDEX NAME)", XP093117806, retrieved from STN Database accession no. 2705477-27-4
DATABASE REGISTRY 29 September 2015 (2015-09-29), ANONYMOUS : "1-Pyrrolidinepropanoic acid, 2,5-dioxo-, (2,6- dichloro-3-pyridinyl) methyl ester (CA INDEX NAME)", XP093117808, retrieved from STN Database accession no. 1808839-89-5
DATABASE REGISTRY 26 February 2019 (2019-02-26), ANONYMOUS : "Norleucine, 4-methyl-, 2, 2,2-trifluoroethyl es ter (CA INDEX NAME)", XP093117811, retrieved from STN Database accession no. 2273065-21-5
SCHROEDER GOTTFRIED K., WOLFENDEN RICHARD: "The Rate Enhancement Produced by the Ribosome: An Improved Model", BIOCHEMISTRY, vol. 46, no. 13, 1 April 2007 (2007-04-01), pages 4037 - 4044, XP093117793, ISSN: 0006-2960, DOI: 10.1021/bi602600p
LAROCHE BENJAMIN, TANG XINJUN, ARCHER GAÉTAN, DI SANZA RICCARDO, MELCHIORRE PAOLO: "Photochemical Chemoselective Alkylation of Tryptophan-Containing Peptides", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 23, no. 2, 15 January 2021 (2021-01-15), US , pages 285 - 289, XP093117798, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.0c03735
ZHANG SHUANGSHUANG, YU JUN, LI HUIYING, MAO DONGSEN, LU GUANZHONG: "High-effective approach from amino acid esters to chiral amino alcohols over Cu/ZnO/Al2O3 catalyst and its catalytic reaction mechanism", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 6, no. 1, US , XP093117800, ISSN: 2045-2322, DOI: 10.1038/srep33196
DATABASE REGISTRY 29 September 2015 (2015-09-29), ANONYMOUS : "1-Pyrrolidinepropanoic acid, 2,5-dioxo-, (2,6- dichloro-3-pyridinyl) methyl ester (CA INDEX NAME)", XP093117808, retrieved from STN Database accession no. 1808839-89-5
DATABASE REGISTRY 26 February 2019 (2019-02-26), ANONYMOUS : "Norleucine, 4-methyl-, 2, 2,2-trifluoroethyl es ter (CA INDEX NAME)", XP093117811, retrieved from STN Database accession no. 2273065-21-5
SCHROEDER GOTTFRIED K., WOLFENDEN RICHARD: "The Rate Enhancement Produced by the Ribosome: An Improved Model", BIOCHEMISTRY, vol. 46, no. 13, 1 April 2007 (2007-04-01), pages 4037 - 4044, XP093117793, ISSN: 0006-2960, DOI: 10.1021/bi602600p
LAROCHE BENJAMIN, TANG XINJUN, ARCHER GAÉTAN, DI SANZA RICCARDO, MELCHIORRE PAOLO: "Photochemical Chemoselective Alkylation of Tryptophan-Containing Peptides", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 23, no. 2, 15 January 2021 (2021-01-15), US , pages 285 - 289, XP093117798, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.0c03735
ZHANG SHUANGSHUANG, YU JUN, LI HUIYING, MAO DONGSEN, LU GUANZHONG: "High-effective approach from amino acid esters to chiral amino alcohols over Cu/ZnO/Al2O3 catalyst and its catalytic reaction mechanism", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 6, no. 1, US , XP093117800, ISSN: 2045-2322, DOI: 10.1038/srep33196
Attorney, Agent or Firm:
YAMAMOTO, Osamu et al. (JP)
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