Title:
AMINO ACID ANALOGUES
Document Type and Number:
WIPO Patent Application WO2003095421
Kind Code:
A8
Abstract:
In the present specification we describe a new class of compounds, designed to modulate the ability of blood vessels to synthesize NO from L-arginine. In particular we have identified novel compounds which enhance the entry of L-arginine into cells. These compounds improve endothelial function, and thereby have the potential to retard the progression of vascular disease in conditions such as hypertension, heart failure and diabetes. This new class of drugs may also have other potentially, relevant pharmacological actions, including anti-hypertensive and anti-anginal actions.
Inventors:
EDE NICHOLAS J (AU)
KAYE DAVID M (AU)
TRAINOR ROBERT W (AU)
HUNTER ANDREW N (AU)
KAYE DAVID M (AU)
TRAINOR ROBERT W (AU)
HUNTER ANDREW N (AU)
Application Number:
PCT/AU2003/000551
Publication Date:
March 18, 2004
Filing Date:
May 08, 2003
Export Citation:
Assignee:
MIMOTOPES PTY LTD (AU)
BAKER MED RES INST (AU)
EDE NICHOLAS J (AU)
KAYE DAVID M (AU)
TRAINOR ROBERT W (AU)
HUNTER ANDREW N (AU)
BAKER MED RES INST (AU)
EDE NICHOLAS J (AU)
KAYE DAVID M (AU)
TRAINOR ROBERT W (AU)
HUNTER ANDREW N (AU)
International Classes:
C07D307/52; A61K31/155; A61K31/166; A61K31/341; A61K31/351; A61K31/36; A61K31/44; A61P3/10; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P9/12; C07C279/16; C07C279/18; C07D213/74; C07D309/06; C07D407/12; (IPC1-7): C07C279/18; A61K31/155; A61K31/44; A61K31/341; A61K31/351; A61P9/00
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