Title:
AMINO ACID HAVING FLUORINE AT α-POSITION, AND DERIVATIVE OF SAME
Document Type and Number:
WIPO Patent Application WO/2023/243699
Kind Code:
A1
Abstract:
A first purpose of the present invention is to provide an amino acid compound in which the α-position of the amino acid compound is fluorinated by performing a fluorination reaction with respect to the α-position at a high yield. A second purpose of the present invention is to provide an amino acid compound in which the α-position of the amino acid compound is fluorinated by performing a fluorination reaction with respect to the α-position in a highly enantioselective manner. The present invention pertains to: an amino acid having fluorine at the α-position; and a derivative of the same.
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Inventors:
XU PENGYU (JP)
YONEYAMA SHIN (JP)
ARIMITSU SATORU (JP)
GENKA RIKO (JP)
YONEYAMA SHIN (JP)
ARIMITSU SATORU (JP)
GENKA RIKO (JP)
Application Number:
PCT/JP2023/022346
Publication Date:
December 21, 2023
Filing Date:
June 16, 2023
Export Citation:
Assignee:
SYNCREST INC (JP)
UNIV OF THE RYUKYUS (JP)
UNIV OF THE RYUKYUS (JP)
International Classes:
C07D209/48; C07B61/00
Domestic Patent References:
| WO2016140189A1 | 2016-09-09 |
Foreign References:
| JP2002506068A | 2002-02-26 | |||
| JP2009091331A | 2009-04-30 |
Other References:
WEI QIANG, MA YAO, LI LI, LIU QINGFEI, LIU ZIJIE, LIU GANG: "Synthesis of Quaternary α-Fluorinated α-Amino Acid Derivatives via Coordinating Cu(II) Catalytic α-C(sp 3 )–H Direct Fluorination", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 20, no. 22, 16 November 2018 (2018-11-16), US , pages 7100 - 7103, XP093118270, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.8b03044
SIM JAEHOON, CAMPBELL MARK W., MOLANDER GARY A.: "Synthesis of α-Fluoro-α-amino Acid Derivatives via Photoredox-Catalyzed Carbofluorination", ACS CATALYSIS, AMERICAN CHEMICAL SOCIETY, US, vol. 9, no. 2, 1 February 2019 (2019-02-01), US , pages 1558 - 1563, XP093118279, ISSN: 2155-5435, DOI: 10.1021/acscatal.8b04284
DHANDE SUDHAKAR REDDY; NORIO SHIBATA; JUN NAGAI; SHUICHI NAKAMURA; TAKESHI TORU; SHUJI KANEMASA: "Desymmetrization‐like Catalytic Enantioselective Fluorination of Malonates and Its Application to Pharmaceutically Attractive Molecules", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, HOBOKEN, USA, vol. 47, no. 1, 13 November 2007 (2007-11-13), Hoboken, USA, pages 164 - 168, XP072064698, ISSN: 1433-7851, DOI: 10.1002/anie.200704093
SIM JAEHOON, CAMPBELL MARK W., MOLANDER GARY A.: "Synthesis of α-Fluoro-α-amino Acid Derivatives via Photoredox-Catalyzed Carbofluorination", ACS CATALYSIS, AMERICAN CHEMICAL SOCIETY, US, vol. 9, no. 2, 1 February 2019 (2019-02-01), US , pages 1558 - 1563, XP093118279, ISSN: 2155-5435, DOI: 10.1021/acscatal.8b04284
DHANDE SUDHAKAR REDDY; NORIO SHIBATA; JUN NAGAI; SHUICHI NAKAMURA; TAKESHI TORU; SHUJI KANEMASA: "Desymmetrization‐like Catalytic Enantioselective Fluorination of Malonates and Its Application to Pharmaceutically Attractive Molecules", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, HOBOKEN, USA, vol. 47, no. 1, 13 November 2007 (2007-11-13), Hoboken, USA, pages 164 - 168, XP072064698, ISSN: 1433-7851, DOI: 10.1002/anie.200704093
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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