Title:
AMINO ALCOHOL DERIVATIVE, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/001342
Kind Code:
A1
Abstract:
The present invention belongs to the field of medicine, and specifically discloses an amino alcohol derivative represented by Formula I, a pharmaceutically acceptable salt, solvate, polymorph or prodrug thereof. In addition, the present invention also disclose a pharmaceutical composition comprising the above substances, and a use of the substance in the preparation of a medicament for the prevention and treatment of an immune inflammatory disease, or a disease or condition associated with immunological competence such as multiple sclerosis, ALS, CIDP, systemic lupus erythematosus, rheumatoid arthritis, ulcerative colitis, psoriasis, polymyositis, etc.
Inventors:
JI QI (CN)
ZHANG XINGMIN (CN)
DU ZHENJIAN (CN)
GONG LONGLONG (CN)
WANG LEI (CN)
GAO CONGMIN (CN)
DU MEIJING (CN)
ZHANG XINGMIN (CN)
DU ZHENJIAN (CN)
GONG LONGLONG (CN)
WANG LEI (CN)
GAO CONGMIN (CN)
DU MEIJING (CN)
Application Number:
PCT/CN2018/092233
Publication Date:
January 03, 2019
Filing Date:
June 21, 2018
Export Citation:
Assignee:
BEIJING FORELAND PHARMA CO LTD (CN)
International Classes:
C07D271/107; A61K31/4245; A61P19/02; A61P29/00; A61P37/06
Domestic Patent References:
| WO2013181840A1 | 2013-12-12 |
Foreign References:
| CN102250035A | 2011-11-23 | |||
| CN102816128A | 2012-12-12 | |||
| CN101768086A | 2010-07-07 |
Other References:
WU, YI: "Synthesis and Biological Evaluation of Amino Alcohol Containing 1, 3, 4- Oxadiazole", CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, vol. 32, no. 5, 17 September 2016 (2016-09-17), pages 760 - 767, XP009518392, ISSN: 1005-9040, DOI: 10.1007/s40242-016-6164-9
CAREYSUNDBERG: "ADVANCED ORGANIC CHEMISTRY", 2000, PLENUM PRESS
GOODMANGILMAN: "Pergamon and Remington's, Pharmaceutical Sciences", MACK PUBLISHING CO., article "The Pharmacological Basis of Therapeutics"
"Remingtong's Pharmaceutical Scicences", vol. 42, 1985, MACK PUBLISHING COMPANY, pages: 1418 - 396
JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 66, 1977, pages 2
M. CAIRA ET AL., J. PHARMACEUTICAL SCI., vol. 93, no. 3, 2004, pages 601 - 611
E. C. VAN TONDER ET AL., AAPS PHARMSCITECH., vol. 5, 2004, pages 1
A. L. BINGHAM ET AL., CHEM. COMMUN., 2001, pages 603 - 604
T. HIGUCHIV. STELLA, PRO-DRUGS AS NOVEL DELIVERY SYSTEMS, vol. 14, 1987
"the A.C.S. Symposium Series", 1987, AMERICAN PHARMACEUTICAL ASSOCIATION, article "Bioreversible Carriers in Drug Design"
BUNDGAARD, H.: "A Textbook of Drug Design and Development", vol. 5, 1991, article "Design and Application of Prodrugs", pages: 113 - 191
BUNDGAARD, H.: "Advanced Drug Delivery Review", vol. 8, 1992, pages: 1 - 38
See also references of EP 3647309A4
CAREYSUNDBERG: "ADVANCED ORGANIC CHEMISTRY", 2000, PLENUM PRESS
GOODMANGILMAN: "Pergamon and Remington's, Pharmaceutical Sciences", MACK PUBLISHING CO., article "The Pharmacological Basis of Therapeutics"
"Remingtong's Pharmaceutical Scicences", vol. 42, 1985, MACK PUBLISHING COMPANY, pages: 1418 - 396
JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 66, 1977, pages 2
M. CAIRA ET AL., J. PHARMACEUTICAL SCI., vol. 93, no. 3, 2004, pages 601 - 611
E. C. VAN TONDER ET AL., AAPS PHARMSCITECH., vol. 5, 2004, pages 1
A. L. BINGHAM ET AL., CHEM. COMMUN., 2001, pages 603 - 604
T. HIGUCHIV. STELLA, PRO-DRUGS AS NOVEL DELIVERY SYSTEMS, vol. 14, 1987
"the A.C.S. Symposium Series", 1987, AMERICAN PHARMACEUTICAL ASSOCIATION, article "Bioreversible Carriers in Drug Design"
BUNDGAARD, H.: "A Textbook of Drug Design and Development", vol. 5, 1991, article "Design and Application of Prodrugs", pages: 113 - 191
BUNDGAARD, H.: "Advanced Drug Delivery Review", vol. 8, 1992, pages: 1 - 38
See also references of EP 3647309A4
Attorney, Agent or Firm:
BEIJING INTELLEGAL INTELLECTUAL PROPERTY AGENT LTD. (CN)
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