AMINO LIPID, PREPARATION METHOD THEREFOR, AND USE THEREOF

WIPO Patent Application WO/2023/142600

A1

The present invention relates to an ionizable amino lipid represented by formula (I) or a pharmaceutically acceptable salt thereof. The amino lipid can be used to deliver nucleic acids and small molecule drugs and has two ester bonds, which significantly enhances the lysosome escape ability of the ionizable amino lipid and facilitates the release of delivery targets such as target drugs or genes, thereby improving delivery efficiency and showing an excellent ability to deliver nucleic acids into cells.

JP4183864	Method for producing quaternary ammonium salt
WO/2005/030701	PROCESS FOR THE PREPARATION OF LOWER TOXICITY QUATERNARY AMMONIUM COMPOUNDS AND COMPOSITIONS THEREOF
JP6031048	A manufacturing process of the solid of amino acid

ZHA GAOFENG (CN)
PENG XINHUA (CN)
XIA HENG (CN)

PCT/CN2022/131322

August 03, 2023

November 11, 2022

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SHENZHEN MAGICRNA BIOTECHNOLOGY CO LTD (CN)

C07C229/12; A61K9/51; A61K47/18; A61K47/22; A61K48/00; A61P7/00; A61P7/04; A61P7/06; A61P31/00; A61P35/00; A61P37/08; A61P39/02; C07C67/26; C07C69/28; C07C227/18; C07D207/16; C07D211/34; C07D211/62; C07D295/15

CN114105799A	2022-03-01
US20160311759A1	2016-10-27

DATABASE Registry CAS; 29 July 2016 (2016-07-29), XP093081953, retrieved from STN Database accession no. 1962944-97-3

SHENZHEN CREATEFORTUNE INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)

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