Title:
AMINOBUTANOIC ACID DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1999/019296
Kind Code:
A1
Abstract:
Aminobutanoic acid derivatives represented by general formula (I) and salts thereof (wherein each symbol is as defined in the description). The derivatives inhibit matrix metalloproteinases and are therefore useful for the prevention and/or treatment of rheumatism, osteoarthritis, pathologic bone resorption, osteoporosis, periodontal diseases, interstitial nephritis, arteriosclerosis, pulmonary emphysema, hepatic cirrhosis, corneal injury, diseases due to metastasis and infiltration of cancer cells or proliferation thereof, autoimmune diseases (such as Crohn's disease and Sjögren's disease), diseases due to transmigration of white blood cells or infiltration thereof, neovascularization, multiple sclerosis, aortic aneurysm, endometritis and so on.
Inventors:
TAKAHASHI KANJI (JP)
SUGIURA TSUNEYUKI (JP)
SUGIURA TSUNEYUKI (JP)
Application Number:
PCT/JP1998/004529
Publication Date:
April 22, 1999
Filing Date:
October 07, 1998
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
TAKAHASHI KANJI (JP)
SUGIURA TSUNEYUKI (JP)
TAKAHASHI KANJI (JP)
SUGIURA TSUNEYUKI (JP)
International Classes:
A61K31/16; A61K31/165; A61P19/00; A61P43/00; C07C233/47; C07C233/63; C07C233/83; C07C235/06; C07C235/16; C07C235/42; C07C235/52; C07C237/22; C07C243/00; C07C243/34; C07C255/41; C07C255/57; C07C259/06; C07C259/08; C07C271/16; C07C271/22; C07C311/21; C07C323/42; C07C323/60; C07C327/30; C07D207/327; C07D207/34; C07D207/40; C07D207/46; C07D209/18; C07D209/42; C07D211/14; C07D211/46; C07D211/62; C07D213/54; C07D213/56; C07D213/68; C07D213/70; C07D213/81; C07D215/14; C07D233/61; C07D233/74; C07D253/08; C07D263/57; C07D277/62; C07D295/13; C07D307/54; C07D307/68; C07D307/81; C07D307/84; C07D309/12; C07D333/16; C07D333/38; C07D333/44; C07D333/60; C07D405/12; C07D521/00; C07F7/18; C07D207/32; C07D263/56; (IPC1-7): C07C233/63; C07C233/83; C07C235/52; C07C235/42; C07C243/34; C07C259/06; C07C271/16; C07C275/36; C07C311/21; C07C323/41; C07C323/42; C07C323/43; C07C323/60; C07D207/327; C07D207/40; C07D207/46; C07D209/24; C07D211/14; C07D211/62; C07D211/70; C07D213/81; C07D215/02; C07D233/61; C07D233/72; C07D263/56; C07D277/64; C07D307/81; C07D333/24; C07D339/08; C07D405/12; C07F5/02; C07F7/18
Foreign References:
| US4971978A | 1990-11-20 | |||
| US2745875A | 1956-05-15 | |||
| JPS63165352A | 1988-07-08 | |||
| JPS6210052A | 1987-01-19 | |||
| JPH09505038A | 1997-05-20 |
Other References:
OESAPAY G., SZILAGYI I., SERES J.: "CONVERSION OF AMINO ACIDS AND DEPEPTIDES INTO THEIR PHOSPHONIC ANALOGS. AMINOALKYLPHOSPHONIC ACIDS AND PEPTIDES II.", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 43., no. 13., 1 January 1987 (1987-01-01), AMSTERDAM, NL, pages 2977 - 2983., XP002915048, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(01)86836-8
See also references of EP 1024134A4
See also references of EP 1024134A4
Attorney, Agent or Firm:
Ohie, Kunihisa (Ohie Patent Office Horiguchi No. 2 Building
7th floor 2-6 Nihonbashi-Ningyocho 2-chome
Chuo-ku Tokyo, JP)
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