Title:
γ-AMINOBUTYRIC ACID MODULATOR CRYSTAL FORM X, PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/155057
Kind Code:
A1
Abstract:
A crystal form X of 3α-hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5β-pregnan-20-one, a preparation method of said crystal form and an application thereof in preparing a drug for treatment of central nervous system disease.
Inventors:
REN GUOBIN (CN)
JI WEIJIE (CN)
YI DONGXU (CN)
HUANG JIAJUN (CN)
JI WEIJIE (CN)
YI DONGXU (CN)
HUANG JIAJUN (CN)
Application Number:
PCT/CN2019/074272
Publication Date:
August 06, 2020
Filing Date:
January 31, 2019
Export Citation:
Assignee:
SHENZHEN RENTAI PHARMATECH LTD (CN)
International Classes:
C07D231/14; A61K31/415; A61P25/00
Domestic Patent References:
| WO2018039378A1 | 2018-03-01 |
Foreign References:
| CN105339381A | 2016-02-17 |
Other References:
GABRIEL MARTINEZ BOTELLA; FRANCESCO G SALITURO; BOYD L HARRISON; RICHARD T BERESIS; ZHU BAI; MARIA-JESUS BLANCO; GABRIEL M BELFORT: "Neuroactive Steroids. 2.3α-Hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid)A Receptor", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 18, 28 July 2017 (2017-07-28), pages 7810 - 7819, XP055542843, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b00846
Attorney, Agent or Firm:
SUNSHINE INTELLECTUAL PROPERTY INTERNATIONAL CO., LTD (CN)
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