AMINOCYCLOPENTYL PYRIDOPYRAZINONE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

Title:

AMINOCYCLOPENTYL PYRIDOPYRAZINONE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

Document Type and Number:

WIPO Patent Application WO2005072361

Kind Code:

A3

Abstract:

Compounds of Formula I and Formula II (wherein A, E, j, k, m, n, R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8>, R<9>, R<10>, R<15>, R<16>, R<17>, R<18>, R<19>, R<24>, R<25>, R<26>, R<27>, R<28>, R<29>, R<30>, R<31>, R<32>, R<33>, R<34>, X, Y and Z are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.

Inventors:

BUTORA GABOR (US)
GUIADEEN DEODIALSINGH (US)
KOTHANDARAMAN SHANKARAN (US)
MACCOSS MALCOLM (US)
MILLS SANDER G (US)
YANG LIHU (US)

Application Number:

PCT/US2005/002454

Publication Date:

November 17, 2005

Filing Date:

January 26, 2005

Export Citation:

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Assignee:

MERCK & CO INC (US)
BUTORA GABOR (US)
GUIADEEN DEODIALSINGH (US)
KOTHANDARAMAN SHANKARAN (US)
MACCOSS MALCOLM (US)
MILLS SANDER G (US)
YANG LIHU (US)

International Classes:

A01N43/58; A01N43/60; A01N43/64; A01N43/66; A61K31/495; A61K31/50; A61K31/53; C07D241/36; C07D253/08; C07D471/00; C07D471/04; C07D487/00; (IPC1-7): A01N43/64; A01N43/58; A01N43/60; A01N43/66; A61K31/495; A61K31/50; A61K31/53; C07D241/36; C07D253/08; C07D471/00; C07D487/00

Domestic Patent References:

WO2003092586A2

2003-11-13

Other References: