Title:
AMINOPYRAZOLE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2011/016528
Kind Code:
A1
Abstract:
A compound represented by formula (I) or a pharmacologically acceptable salt thereof, which can inhibit a fibroblast growth factor receptor (FGFR) family kinase in cancer tissues. (In the formula, A represents a 5- to 10-membered heteroaryl group, or a C6-10 aryl group; R1 and R2 independently represent H, OH, X, CN, NO2, a C1-4 haloalkyl group, a C1-6 alkyl group, or the like ; R3 represents H, a C1-5 alkyl group, a C6-10 aryl group, a C1-5 alkyl group, or a C1-4 haloalkyl group; and R4 represents H, X, a C1-3 alkyl group, a C1-4 haloalkyl group, OH, CN, NO2, or the like.)
Inventors:
TAKA NAOKI (JP)
OHMORI MASAYUKI (JP)
TAKAMI KYOKO (JP)
MATSUSHITA MASAYUKI (JP)
HAYASE TADAKATSU (JP)
HYODO IKUMI (JP)
KOCHI MASAMI (JP)
NISHII HIROKI (JP)
EBIIKE HIROSATO (JP)
NAKANISHI YOSHITO (JP)
MIO TOSHIYUKI (JP)
WANG LISHA (CN)
ZHAO WEILI (CN)
OHMORI MASAYUKI (JP)
TAKAMI KYOKO (JP)
MATSUSHITA MASAYUKI (JP)
HAYASE TADAKATSU (JP)
HYODO IKUMI (JP)
KOCHI MASAMI (JP)
NISHII HIROKI (JP)
EBIIKE HIROSATO (JP)
NAKANISHI YOSHITO (JP)
MIO TOSHIYUKI (JP)
WANG LISHA (CN)
ZHAO WEILI (CN)
Application Number:
PCT/JP2010/063315
Publication Date:
February 10, 2011
Filing Date:
August 05, 2010
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
HOFFMANN LA ROCHE (CH)
TAKA NAOKI (JP)
OHMORI MASAYUKI (JP)
TAKAMI KYOKO (JP)
MATSUSHITA MASAYUKI (JP)
HAYASE TADAKATSU (JP)
HYODO IKUMI (JP)
KOCHI MASAMI (JP)
NISHII HIROKI (JP)
EBIIKE HIROSATO (JP)
NAKANISHI YOSHITO (JP)
MIO TOSHIYUKI (JP)
WANG LISHA (CN)
ZHAO WEILI (CN)
HOFFMANN LA ROCHE (CH)
TAKA NAOKI (JP)
OHMORI MASAYUKI (JP)
TAKAMI KYOKO (JP)
MATSUSHITA MASAYUKI (JP)
HAYASE TADAKATSU (JP)
HYODO IKUMI (JP)
KOCHI MASAMI (JP)
NISHII HIROKI (JP)
EBIIKE HIROSATO (JP)
NAKANISHI YOSHITO (JP)
MIO TOSHIYUKI (JP)
WANG LISHA (CN)
ZHAO WEILI (CN)
International Classes:
A61K31/4184; C07D401/14; A61K31/437; A61K31/4439; A61K31/444; A61K31/454; A61K31/4709; A61K31/496; A61K31/501; A61K31/5377; A61P35/00; A61P35/02; A61P43/00; C07D403/14; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D471/04; C07D491/056
Domestic Patent References:
| WO2001012600A1 | 2001-02-22 | |||
| WO2010010017A1 | 2010-01-28 |
Foreign References:
| JP2007521278A | 2007-08-02 | |||
| JP2003509495A | 2003-03-11 |
Other References:
CYTOKINE & GROWTH FACTOR REVIEWS, vol. 16, 2005, pages 139 - 149
BREAST CANCER RESEARCH, vol. 9, 2007, pages R23
CANCER RES, vol. 65, no. 13, 2005, pages 5561 - 70
PNAS, vol. 102, no. 40, 2005, pages 14344 - 14349
ACTA HAEMATOL, vol. 107, 2002, pages 101 - 107
NATURE MEDICINE, vol. 3, 1997, pages 887 - 89
J PATHOL., vol. 201, no. 3, November 2003 (2003-11-01), pages 439 - 50
CELL PATHOL., vol. 22, no. 4, 2001, pages 229 - 34
CANCER RES, vol. 68, no. 17, 2008, pages 6902 - 7
BLOOD, vol. 101, 2003, pages 4569 - 4575
NAT GENET., vol. 23, no. 1, September 1999 (1999-09-01), pages 18 - 20
HIROYA, K. ET AL., J. ORG. CHEM., vol. 69, 2004, pages 1126
HIROYA, K. ET AL., TETRAHEDRON LETTERS, vol. 43, 2002, pages 1277
LACHANCE, N. ET AL., SYNTHESIS, vol. 15, 2005, pages 2571
ROMANELLI, M. N. ET AL., ARKIVOC, 2004, pages 286
ROY, P. J. ET AL., SYNTHESIS, vol. 16, 2005, pages 2751
SMITH; MARCH: "March's Advanced Organic Chemistry", 2001, JOHN WILEY & SONS
RICHARD C. LAROCK: "Comprehensive Organic Transformations", 1989, VCH PUBLISHERS, INC.
GREENE; WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS
See also references of EP 2471786A4
BREAST CANCER RESEARCH, vol. 9, 2007, pages R23
CANCER RES, vol. 65, no. 13, 2005, pages 5561 - 70
PNAS, vol. 102, no. 40, 2005, pages 14344 - 14349
ACTA HAEMATOL, vol. 107, 2002, pages 101 - 107
NATURE MEDICINE, vol. 3, 1997, pages 887 - 89
J PATHOL., vol. 201, no. 3, November 2003 (2003-11-01), pages 439 - 50
CELL PATHOL., vol. 22, no. 4, 2001, pages 229 - 34
CANCER RES, vol. 68, no. 17, 2008, pages 6902 - 7
BLOOD, vol. 101, 2003, pages 4569 - 4575
NAT GENET., vol. 23, no. 1, September 1999 (1999-09-01), pages 18 - 20
HIROYA, K. ET AL., J. ORG. CHEM., vol. 69, 2004, pages 1126
HIROYA, K. ET AL., TETRAHEDRON LETTERS, vol. 43, 2002, pages 1277
LACHANCE, N. ET AL., SYNTHESIS, vol. 15, 2005, pages 2571
ROMANELLI, M. N. ET AL., ARKIVOC, 2004, pages 286
ROY, P. J. ET AL., SYNTHESIS, vol. 16, 2005, pages 2751
SMITH; MARCH: "March's Advanced Organic Chemistry", 2001, JOHN WILEY & SONS
RICHARD C. LAROCK: "Comprehensive Organic Transformations", 1989, VCH PUBLISHERS, INC.
GREENE; WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS
See also references of EP 2471786A4
Attorney, Agent or Firm:
SHIMIZU, Hatsushi et al. (JP)
Spring water Original aim (JP)
Spring water Original aim (JP)
Download PDF: