Title:
AMINOPYRIDINE BASED BUFFERS WITH WIDE BUFFERING RANGES ANTIBIOTICS AND MYELIN DISEASE THERAPY
Document Type and Number:
WIPO Patent Application WO/2019/140417
Kind Code:
A1
Abstract:
Amines and amine derivatives that improve the buffering range, and / or reduce the chelation and other negative interactions of the buffer and the system to be buffered. Aminopyridines channel blocking, combined with buffering and zwitterionic charge states make promising therapies for myelin diseases.
Inventors:
DALY THOMAS (US)
Application Number:
PCT/US2019/013571
Publication Date:
July 18, 2019
Filing Date:
January 15, 2019
Export Citation:
Assignee:
DALY THOMAS P (US)
International Classes:
C07C233/07; A61K31/167; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/444; C07D213/75; C07D401/14
Domestic Patent References:
| WO2003032921A2 | 2003-04-24 | |||
| WO2005053610A2 | 2005-06-16 | |||
| WO2006017216A1 | 2006-02-16 | |||
| WO1995031977A1 | 1995-11-30 | |||
| WO2007058927A1 | 2007-05-24 | |||
| WO2008090585A2 | 2008-07-31 |
Foreign References:
| EP2824108A1 | 2015-01-14 | |||
| US6277854B1 | 2001-08-21 | |||
| US20050107355A1 | 2005-05-19 |
Other References:
NISONOFF ALFRED ET AL.: "Annular nitrogen of pyridine as a determinant of immunological specificity", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 79, no. 20, 1957, pages 5565 - 5572, XP055624607
DOLZHENKO A.V. ET AL.: "Substituted amides and hydrazides of dicarboxylic acids. Part 11. Synthesis and pharmacological activity of a series of pyridylamides of dicarboxylic acids", PHARMACEUTICAL CHEMISTRY JOURNAL, vol. 36, no. 23, 2002, pages 125 - 126, XP055624608
EVANS D.W.S. ET AL.: "Synthesis of potential antibacterial agents. III. Derivatives of some a,a'-dialkylglutaric acids", JOURNAL OF THE CHEMICAL SOCIETY, 1957, pages 2104 - 2106, XP055624611, DOI: 10.1039/JR9570002104
MNDZHOYAN A.L. ET AL.: "Derivatives of dibasic carboxylic acids. XVI. 2-Pyridyl- and 4-methyl-2-thiazolylamides of dibasic carboxylic acids", DOKLADY AKADEMII NAUK ARMYANSKOI SSR, vol. 22, 1956, pages 215 - 219
DOLZHENKO A.V. ET AL.: "Substituted amides and hydrazides of dicarboxylic acids. Part 11. Synthesis and pharmacological activity of a series of pyridylamides of dicarboxylic acids", PHARMACEUTICAL CHEMISTRY JOURNAL, vol. 36, no. 23, 2002, pages 125 - 126, XP055624608
EVANS D.W.S. ET AL.: "Synthesis of potential antibacterial agents. III. Derivatives of some a,a'-dialkylglutaric acids", JOURNAL OF THE CHEMICAL SOCIETY, 1957, pages 2104 - 2106, XP055624611, DOI: 10.1039/JR9570002104
MNDZHOYAN A.L. ET AL.: "Derivatives of dibasic carboxylic acids. XVI. 2-Pyridyl- and 4-methyl-2-thiazolylamides of dibasic carboxylic acids", DOKLADY AKADEMII NAUK ARMYANSKOI SSR, vol. 22, 1956, pages 215 - 219
Attorney, Agent or Firm:
KRAFT, Clifford, H. (US)
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