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Title:
AMINOPYRIDINE DERIVATIVES AND THEIR USE AS SELECTIVE ALK-2 INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2018/014829
Kind Code:
A1
Abstract:
The invention relates to a compound of formula (I) in free form or in pharmaceutically acceptable salt form (I) to pharmaceutical compositions comprising said compound and to the use of said compound in the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva.

Inventors:
LI JIALIANG (CN)
ARISTA LUCA (CH)
BABU SREEHARI (IN)
BIAN JIANWEI (CN)
CUI KAI (CN)
DILLON MICHAEL PATRICK (US)
LATTMANN RENE (CH)
LIAO LV (CN)
LIZOS DIMITRIOS (CH)
RAMOS RITA (CH)
STIEFL NIKOLAUS JOHANNES (CH)
ULLRICH THOMAS (CH)
USSELMANN PEGGY (CH)
WANG XIAOYANG (CN)
WAYKOLE LILADHAR MURLIDHAR (CN)
WEILER SVEN (DE)
ZHANG YUBO (CN)
ZHOU YIZONG (CN)
ZHU TINGYING (CN)
Application Number:
PCT/CN2017/093385
Publication Date:
January 25, 2018
Filing Date:
July 18, 2017
Export Citation:
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Assignee:
NOVARTIS AG (CH)
International Classes:
C07D401/10; A61K31/4427; A61P19/00; C07D401/12; C07D401/14; C07D405/14; C07D409/14; C07D411/14; C07D413/00; C07D417/00; C07D419/00
Domestic Patent References:
WO2014151871A22014-09-25
WO2014138088A12014-09-12
WO2008033408A22008-03-20
WO2009114180A12009-09-17
WO1994011502A21994-05-26
WO2008030611A22008-03-13
WO2012023113A22012-02-23
WO2012077031A12012-06-14
WO2007123896A22007-11-01
WO2014160203A22014-10-02
WO2014138088A12014-09-12
WO2015152183A12015-10-08
WO2014151871A22014-09-25
WO2004078163A22004-09-16
WO2007022935A12007-03-01
WO2012087938A12012-06-28
Other References:
SHORE ET AL., NAT. GENET., vol. 38, no. 5, 2006, pages 525 - 7
GOMEZ-SANCHEZ ET AL., TETRAHEDRON, vol. 61, no. 5, 2005, pages 1207 - 1219
QUIRANTE, J. ET AL., J. ORG. CHEM., vol. 67, no. 7, 2002, pages 2323 - 2328
See also references of EP 3487851A4
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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