Title:
AMINOTETRAHYDROISOQUINOLINE DERIVATIVES AS ANALGESICS
Document Type and Number:
WIPO Patent Application WO2003014089
Kind Code:
A8
Abstract:
Tetrahydroisoquinolines are provided having a secondary, tertiary or quaternary amino group spaced by three carbon atoms from the ring nitrogen, and pharmaceutically acceptable salts and prodrugs thereof. Preferred compounds are of Formula (I), wherein R<1>, R<2> and R<5> are independently selected from the group consisting of hydrogen, C1-6 alkyl and a moiety wherein any two of R<1>, R<2> and R<5>, together with the nitrogen to which they are attached, form a heterocyclic ring of 2 to 5 carbons, provided that R<1> and R<2>, and R<5> when present, are not each hydrogen, R<3> and R<4> are independently selected from the group of moieties which are effective to alter the solubility of the compound in physiological fluids or pharmaceutical carriers n and m are independently selected from integers of 0 to 3 and 0 to 4 respectively, p is an integer 0 or 1 and pharmaceutically acceptable salts and prodrugs thereof.
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Inventors:
GLENNON RICHARD A (US)
MARTIN BILLY R (US)
DUKAT MALGOZATA (US)
DAMAJ IMAD M (US)
MARTIN BILLY R (US)
DUKAT MALGOZATA (US)
DAMAJ IMAD M (US)
Application Number:
PCT/US2002/023698
Publication Date:
May 27, 2004
Filing Date:
July 25, 2002
Export Citation:
Assignee:
UNIV VIRGINIA COMMONWEALTH (US)
GLENNON RICHARD A (US)
MARTIN BILLY R (US)
DUKAT MALGOZATA (US)
DAMAJ IMAD M (US)
GLENNON RICHARD A (US)
MARTIN BILLY R (US)
DUKAT MALGOZATA (US)
DAMAJ IMAD M (US)
International Classes:
A61P29/00; C07D217/02; (IPC1-7): C07D217/02; A61K31/472; A61P29/00
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