Title:
AMORPHOUS FORM OF NITROGEN-CONTAINING TRICYCLIC COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/104421
Kind Code:
A1
Abstract:
The present invention relates to an amorphous form of a nitrogen-containing tricyclic compound and a use thereof, a pharmaceutical composition containing the compound in the amorphous form, and the use of the compound in the amorphous form or the pharmaceutical composition in the preparation of a drug for preventing, treating or alleviating FXR-mediated diseases in a patient.
Inventors:
YANG XINYE (CN)
CHEN LIANG (CN)
SHAN YUEFENG (CN)
WANG XIAOJUN (CN)
CHEN LIANG (CN)
SHAN YUEFENG (CN)
WANG XIAOJUN (CN)
Application Number:
PCT/CN2020/132104
Publication Date:
June 03, 2021
Filing Date:
November 27, 2020
Export Citation:
Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C07D491/044; A61K31/42; A61K31/4353; A61P1/00; A61P1/16; A61P3/00; A61P3/06; A61P3/10; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P35/00; C07D261/08
Domestic Patent References:
| WO2019089664A1 | 2019-05-09 | |||
| WO2019089672A1 | 2019-05-09 | |||
| WO2018024224A1 | 2018-02-08 |
Foreign References:
| CN107686486A | 2018-02-13 | |||
| CN105884758A | 2016-08-24 | |||
| CN110128432A | 2019-08-16 | |||
| CN110177783A | 2019-08-27 | |||
| CN201911201723A | 2019-11-29 | |||
| CN107686486A | 2018-02-13 |
Other References:
SEOL ET AL., MOL.ENDOCRINOL, vol. 9, 1995, pages 72 - 85
FORMAN ET AL., CELL, vol. 81, 1995, pages 687 - 693
MAKISHIMA ET AL., SCIENCE, vol. 284, 1999, pages 1365 - 1368
WANG ET AL., MOI.CELL, vol. 3, 1999, pages 543 - 553
URIZAR ET AL., J.BIOL.CHEM., vol. 275, 2000, pages 39313 - 393170
CRAWLEY, EXPERT OPINION THER. PATENTS, vol. 20, 2010, pages 1047 - 1057
FRANK G. SCHAAP ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, 2005, pages 5383 - 5402
"Remington: The Science and Practice of Pharmacy", 2005, LIPPINCOTT WILLIAMS& WILKINS
"Encyclopedia of Pharmaceutical Technology", 1988, MARCEL DEKKER
See also references of EP 4067361A4
FORMAN ET AL., CELL, vol. 81, 1995, pages 687 - 693
MAKISHIMA ET AL., SCIENCE, vol. 284, 1999, pages 1365 - 1368
WANG ET AL., MOI.CELL, vol. 3, 1999, pages 543 - 553
URIZAR ET AL., J.BIOL.CHEM., vol. 275, 2000, pages 39313 - 393170
CRAWLEY, EXPERT OPINION THER. PATENTS, vol. 20, 2010, pages 1047 - 1057
FRANK G. SCHAAP ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, 2005, pages 5383 - 5402
"Remington: The Science and Practice of Pharmacy", 2005, LIPPINCOTT WILLIAMS& WILKINS
"Encyclopedia of Pharmaceutical Technology", 1988, MARCEL DEKKER
See also references of EP 4067361A4
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