Title:
AMPHIPHILIC BLOCK POLYMER, CHEMORADIOTHERAPY NANO SENSITIZER, AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2023/237060
Kind Code:
A1
Abstract:
The present invention relates to the field of biomedical macromolecular materials, and particularly, to an amphiphilic block polymer, a chemoradiotherapy nano sensitizer, and a method for preparing same. By means of chemical modification, the prepared amphiphilic block polymer is provided with the characteristics of deep tumor penetration and enzyme-responsive drug release/activation. An anoxia-responsive chemotherapeutic prodrug and the amphiphilic block polymer self-assemble by means of physical embedment to give a stable chemoradiotherapy nano sensitizer with a high drug loading capacity and the characteristics of charge reversal and cascade response. In a hypoxic tumor microenvironment that affects the efficacy of individualized therapies for many common tumors, the chemotherapeutic prodrug and the amphiphilic block polymer released by the chemoradiotherapy nano sensitizer can effectively sensitize the tumor cells to chemoradiotherapies, and can achieve deep penetration of drugs and solve the problem of hypoxic desensitization at the same time.
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Inventors:
YU QINGSONG (CN)
GAN ZHIHUA (CN)
TANG XIAOHU (CN)
YU YANTING (CN)
GAN ZHIHUA (CN)
TANG XIAOHU (CN)
YU YANTING (CN)
Application Number:
PCT/CN2023/099185
Publication Date:
December 14, 2023
Filing Date:
June 08, 2023
Export Citation:
Assignee:
UNIV BEIJING CHEM TECH (CN)
International Classes:
A61K33/243; C08F293/00; A61K45/00; A61K47/32; A61K47/54; A61P35/00; C08F2/38; C08F8/32
Foreign References:
| CN114989375A | 2022-09-02 | |||
| CN113801276A | 2021-12-17 | |||
| US20200215197A1 | 2020-07-09 | |||
| CN110694076A | 2020-01-17 |
Other References:
TANG XIAOHU, DU XIAOMENG, YU YANTING, QIN MENG, QIAN LILI, ZHANG MENG, YANG YAN, YU QINGSONG, GAN ZHIHUA: "Deep‐Penetrating Triple‐Responsive Prodrug Nanosensitizer Actuates Efficient Chemoradiotherapy in Pancreatic Ductal Adenocarcinoma Models", SMALL, WILEY, HOBOKEN, USA, vol. 18, no. 31, 1 August 2022 (2022-08-01), Hoboken, USA, XP093113942, ISSN: 1613-6810, DOI: 10.1002/smll.202202834
GLASS EVAN B., MASJEDI SHIRIN, DUDZINSKI STEPHANIE O., WILSON ANDREW J., DUVALL CRAIG L., YULL FIONA E., GIORGIO TODD D.: "Optimizing Mannose “Click” Conjugation to Polymeric Nanoparticles for Targeted siRNA Delivery to Human and Murine Macrophages", ACS OMEGA, ACS PUBLICATIONS, vol. 4, no. 16, 15 October 2019 (2019-10-15), US , pages 16756 - 16767, XP093113943, ISSN: 2470-1343, DOI: 10.1021/acsomega.9b01465
ZHOU QUAN; SHAO SHIQUN; WANG JINQIANG; XU CHANGHUO; XIANG JIAJIA; PIAO YING; ZHOU ZHUXIAN; YU QINGSONG; TANG JIANBIN; LIU XIANGRUI: "Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy", NATURE NANOTECHNOLOGY, NATURE PUB. GROUP, INC., LONDON, vol. 14, no. 8, 1 July 2019 (2019-07-01), London , pages 799 - 809, XP036851969, ISSN: 1748-3387, DOI: 10.1038/s41565-019-0485-z
GLASS EVAN B., MASJEDI SHIRIN, DUDZINSKI STEPHANIE O., WILSON ANDREW J., DUVALL CRAIG L., YULL FIONA E., GIORGIO TODD D.: "Optimizing Mannose “Click” Conjugation to Polymeric Nanoparticles for Targeted siRNA Delivery to Human and Murine Macrophages", ACS OMEGA, ACS PUBLICATIONS, vol. 4, no. 16, 15 October 2019 (2019-10-15), US , pages 16756 - 16767, XP093113943, ISSN: 2470-1343, DOI: 10.1021/acsomega.9b01465
ZHOU QUAN; SHAO SHIQUN; WANG JINQIANG; XU CHANGHUO; XIANG JIAJIA; PIAO YING; ZHOU ZHUXIAN; YU QINGSONG; TANG JIANBIN; LIU XIANGRUI: "Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy", NATURE NANOTECHNOLOGY, NATURE PUB. GROUP, INC., LONDON, vol. 14, no. 8, 1 July 2019 (2019-07-01), London , pages 799 - 809, XP036851969, ISSN: 1748-3387, DOI: 10.1038/s41565-019-0485-z
Attorney, Agent or Firm:
XIAMEN LIXINLVHE INTELLECTUAL PROPERTY AGENCY CO., LTD. et al. (CN)
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