Title:
AMPHIPHILIC CONJUGATE COMPRISING SELF-ASSEMBLIYABLE PEPTIDE MOLECULE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/101935
Kind Code:
A1
Abstract:
The present invention relates to an amphiphilic conjugate comprising a self-assemblyable peptide and use thereof. A conjugate according to one aspect and a pharmaceutical composition comprising same can be useful in the prevention or treatment of cancer due to the disruption of the membrane integrity of cancer cell lysosomes.
Inventors:
RYU JA HYOUNG (KR)
KIM DO HYUN (KR)
KIM SANG PIL (KR)
KIM DO HYUN (KR)
KIM SANG PIL (KR)
Application Number:
PCT/KR2023/018020
Publication Date:
May 16, 2024
Filing Date:
November 10, 2023
Export Citation:
Assignee:
ULSAN NAT INST SCIENCE & TECH UNIST (KR)
International Classes:
C07K5/107; A61K38/00; A61P35/00
Domestic Patent References:
| WO2017161144A1 | 2017-09-21 |
Foreign References:
| KR20210032847A | 2021-03-25 |
Other References:
DOHYUN KIM: "Spatiotemporal Self-Assembly of Peptide Amphiphiles by Carbonic Anhydrase IX-Targeting Induces Cancer-Lysosomal Membrane Disruption", JACS AU, AMERICAN CHEMICAL SOCIETY ; ACS PUBLICATIONS, vol. 2, no. 11, 28 November 2022 (2022-11-28), pages 2539 - 2547, XP093169418, ISSN: 2691-3704, DOI: 10.1021/jacsau.2c00422
GUN GYUN KIM: "Tumor Targeting Effect of Triphenylphosphonium Cations and Folic Acid Coated with Zr-89-Labeled Silica Nanoparticles", MOLECULES, SPRINGER VERLAG, BERLIN, DE, vol. 25, no. 12, 25 June 2020 (2020-06-25), DE , pages 2922, XP093169419, ISSN: 1433-1373, DOI: 10.3390/molecules25122922
CHIARA TESTA: "First studies on tumor associated carbonic anhydrases IX and XII monoclonal antibodies conjugated to small molecule inhibitors", JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, INFORMA HEALTHCARE, GB, vol. 37, no. 1, 31 December 2022 (2022-12-31), GB , pages 592 - 596, XP093169420, ISSN: 1475-6366, DOI: 10.1080/14756366.2021.2004593
GUN GYUN KIM: "Tumor Targeting Effect of Triphenylphosphonium Cations and Folic Acid Coated with Zr-89-Labeled Silica Nanoparticles", MOLECULES, SPRINGER VERLAG, BERLIN, DE, vol. 25, no. 12, 25 June 2020 (2020-06-25), DE , pages 2922, XP093169419, ISSN: 1433-1373, DOI: 10.3390/molecules25122922
CHIARA TESTA: "First studies on tumor associated carbonic anhydrases IX and XII monoclonal antibodies conjugated to small molecule inhibitors", JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, INFORMA HEALTHCARE, GB, vol. 37, no. 1, 31 December 2022 (2022-12-31), GB , pages 592 - 596, XP093169420, ISSN: 1475-6366, DOI: 10.1080/14756366.2021.2004593
Attorney, Agent or Firm:
THEWAVE IP LAW FIRM (KR)
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