Title:
AMPLIFICATION ENHANCER AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/171179
Kind Code:
A1
Abstract:
The present invention relates to an amplification enhancer. The enhancer comprises a protein molecule capable of initiating the cellular STAT5 and/or STAT3 signaling pathway and comprising the intracellular domain, the transmembrane domain and the extracellular domain. The present invention further relates to a lymphocyte expressing the amplification enhancer and the use thereof as an immunotherapy drug.
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Inventors:
HUANG ZHUO (CN)
LIN YANNI (CN)
ZHAO XUN (CN)
ZHENG XIAOCUI (CN)
LIN YANNI (CN)
ZHAO XUN (CN)
ZHENG XIAOCUI (CN)
Application Number:
PCT/CN2022/075873
Publication Date:
August 18, 2022
Filing Date:
February 10, 2022
Export Citation:
Assignee:
CURE GENETICS CO LTD (CN)
International Classes:
C07K14/715; A61K35/17; A61P35/00; C12N5/10
Domestic Patent References:
| WO2020163634A1 | 2020-08-13 | |||
| WO2020097164A1 | 2020-05-14 |
Foreign References:
| CN109952309A | 2019-06-28 | |||
| CN109694854A | 2019-04-30 | |||
| CN109952309A | 2019-06-28 | |||
| CN106103475A | 2016-11-09 | |||
| CN201780065147A | 2017-08-11 |
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THOMAS SHUM, BILAL OMER, HARUKO TASHIRO, ROBERT L. KRUSE, DIMITRIOS L. WAGNER, KATHAN PARIKH, ZHONGZHEN YI, TIM SAUER, DAOFENG LIU: "Constitutive Signaling from an Engineered IL7 Receptor Promotes Durable Tumor Elimination by Tumor-Redirected T Cells", CANCER DISCOVERY, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 7, no. 11, 1 November 2017 (2017-11-01), US , pages 1238 - 1247, XP055515623, ISSN: 2159-8274, DOI: 10.1158/2159-8290.CD-17-0538
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NEEDLEMANWUNSCH, J. MOL. BIOL., vol. 48, 1970, pages 443 - 453
RICE ET AL.: "EMBOSS: The European Molecular Biology Open Software Suite", TRENDS IN GENETICS, vol. 16, 2000, pages 276 - 277, XP004200114, DOI: 10.1016/S0168-9525(00)02024-2
CELIK ET AL., IMMUNOGENETICS, vol. 68, 2016, pages 29 - 41
HANNOUN ET AL., IMMUNOLOGY LETTERS, vol. 202, 2018, pages 65 - 72
ROLLE ET AL., CELL REP, vol. 14, no. 8, 2018, pages 1967 - 1976
ROLLE ET AL., FRONT IMMUNOL, vol. 9, 2018, pages 2410
ZABEL, M. ET AL.: "The making and function of CAR cells", IMMUNOLOGY LETTERS, vol. 212, 7 June 2019 (2019-06-07), XP085738145, DOI: 10.1016/j.imlet.2019.06.002
BING CHEN, MIN ZHOU, HAI ZHANG, CHEN WANG, XIAOCUI HU, BO WANG, ENXIU WANG: "TREMI/Dap12-based CAR-T cells show potent antitumor activity", IMMUNOTHERAPY, FUTURE MEDICINE LTD., GB, vol. 11, no. 12, 1 August 2019 (2019-08-01), GB , pages 1043 - 1055, XP009534785, ISSN: 1750-743X, DOI: 10.2217/imt-2019-0017
THOMAS SHUM, BILAL OMER, HARUKO TASHIRO, ROBERT L. KRUSE, DIMITRIOS L. WAGNER, KATHAN PARIKH, ZHONGZHEN YI, TIM SAUER, DAOFENG LIU: "Constitutive Signaling from an Engineered IL7 Receptor Promotes Durable Tumor Elimination by Tumor-Redirected T Cells", CANCER DISCOVERY, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 7, no. 11, 1 November 2017 (2017-11-01), US , pages 1238 - 1247, XP055515623, ISSN: 2159-8274, DOI: 10.1158/2159-8290.CD-17-0538
"Genbank", Database accession no. NP003323.1
NEEDLEMANWUNSCH, J. MOL. BIOL., vol. 48, 1970, pages 443 - 453
RICE ET AL.: "EMBOSS: The European Molecular Biology Open Software Suite", TRENDS IN GENETICS, vol. 16, 2000, pages 276 - 277, XP004200114, DOI: 10.1016/S0168-9525(00)02024-2
CELIK ET AL., IMMUNOGENETICS, vol. 68, 2016, pages 29 - 41
HANNOUN ET AL., IMMUNOLOGY LETTERS, vol. 202, 2018, pages 65 - 72
ROLLE ET AL., CELL REP, vol. 14, no. 8, 2018, pages 1967 - 1976
ROLLE ET AL., FRONT IMMUNOL, vol. 9, 2018, pages 2410
Attorney, Agent or Firm:
LIFANG & PARTNERS (CN)
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