Title:
AMYLOID-BINDING, METAL-CHELATING AGENTS
Document Type and Number:
WIPO Patent Application WO2004064869
Kind Code:
A3
Abstract:
The present invention relates to the diagnosis, prevention, and treatment of pathophysiological conditions associated with amyloid accumulation. Bifunctional therapeutic molecules and contrast imaging agents exhibiting a high affinity for amyloid deposits, and pharmaceutical compositions thereof are described. The invention also provides methods of using these bifunctional molecules, contrast imaging agents, and pharmaceutical compositions for detecting the presence of amyloid deposits using imaging techniques; and for preventing or treating amyloidrelated conditions, such as, for example, Alzheimer's disease.
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Inventors:
HUANG XUDONG (US)
Application Number:
PCT/US2004/001669
Publication Date:
March 24, 2005
Filing Date:
January 22, 2004
Export Citation:
Assignee:
GEN HOSPITAL CORP (US)
HUANG XUDONG (US)
HUANG XUDONG (US)
International Classes:
A61K31/425; A61K49/00; A61K49/10; A61K51/04; A61P25/28; C07D277/66; (IPC1-7): A61K49/10; A61K31/425; A61K51/04; A61P25/28
Domestic Patent References:
| WO2002085903A2 | 2002-10-31 | |||
| WO1997041856A1 | 1997-11-13 | |||
| WO2002028441A2 | 2002-04-11 |
Foreign References:
| EP0681844A1 | 1995-11-15 |
Other References:
KLUNK W E ET AL: "Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain", LIFE SCIENCES, PERGAMON PRESS, OXFORD, GB, vol. 69, no. 13, 17 August 2001 (2001-08-17), pages 1471 - 1484, XP002189042, ISSN: 0024-3205
DEZUTTER N A ET AL: "99mTc-MAMA-chrysamine G, a probe for beta-amyloid protein of Alzheimer's disease", EUROPEAN JOURNAL OF NUCLEAR MEDICINE, BERLIN, DE, vol. 26, no. 11, November 1999 (1999-11-01), pages 1392 - 1399, XP002193810, ISSN: 0340-6997
WANG YANMING ET AL: "Synthesis and evaluation of 2-(3'-iodo-4'-aminophenyl)-6-hydroxybenzo thiazole for in vivo quantitation of amyloid deposits in Alzheimer's disease", JOURNAL OF MOLECULAR NEUROSCIENCE, vol. 19, no. 1-2, August 2002 (2002-08-01), pages 11 - 16, XP008031471, ISSN: 0895-8696
WANG YANMING ET AL: "Synthesis and 11C-labelling of (E,E)-1-(3',4'-dihydroxystyryl)-4-(3'- methoxy-4'-hydroxystyryl) benzene for PET imaging of amyloid deposits", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 45, no. 8, July 2002 (2002-07-01), pages 647 - 664, XP002284024, ISSN: 0362-4803
BACSKAI BRIAN J ET AL: "Imaging amyloid-beta deposits in vivo", JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, vol. 22, no. 9, September 2002 (2002-09-01), pages 1035 - 1041, XP008031462, ISSN: 0271-678X
ZHEN WEIGUO ET AL: "Synthesis and amyloid binding properties of rhenium complexes: Preliminary progress toward a reagent for SPECT imaging of Alzheimer's disease brain", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 15, 29 July 1999 (1999-07-29), pages 2805 - 2815, XP002310402, ISSN: 0022-2623
PODUSLO JOSEPH F ET AL: "Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging.", NEUROBIOLOGY OF DISEASE, vol. 11, no. 2, November 2002 (2002-11-01), pages 315 - 329, XP002310403, ISSN: 0969-9961
DEZUTTER N A ET AL: "99mTc-MAMA-chrysamine G, a probe for beta-amyloid protein of Alzheimer's disease", EUROPEAN JOURNAL OF NUCLEAR MEDICINE, BERLIN, DE, vol. 26, no. 11, November 1999 (1999-11-01), pages 1392 - 1399, XP002193810, ISSN: 0340-6997
WANG YANMING ET AL: "Synthesis and evaluation of 2-(3'-iodo-4'-aminophenyl)-6-hydroxybenzo thiazole for in vivo quantitation of amyloid deposits in Alzheimer's disease", JOURNAL OF MOLECULAR NEUROSCIENCE, vol. 19, no. 1-2, August 2002 (2002-08-01), pages 11 - 16, XP008031471, ISSN: 0895-8696
WANG YANMING ET AL: "Synthesis and 11C-labelling of (E,E)-1-(3',4'-dihydroxystyryl)-4-(3'- methoxy-4'-hydroxystyryl) benzene for PET imaging of amyloid deposits", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 45, no. 8, July 2002 (2002-07-01), pages 647 - 664, XP002284024, ISSN: 0362-4803
BACSKAI BRIAN J ET AL: "Imaging amyloid-beta deposits in vivo", JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, vol. 22, no. 9, September 2002 (2002-09-01), pages 1035 - 1041, XP008031462, ISSN: 0271-678X
ZHEN WEIGUO ET AL: "Synthesis and amyloid binding properties of rhenium complexes: Preliminary progress toward a reagent for SPECT imaging of Alzheimer's disease brain", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 15, 29 July 1999 (1999-07-29), pages 2805 - 2815, XP002310402, ISSN: 0022-2623
PODUSLO JOSEPH F ET AL: "Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging.", NEUROBIOLOGY OF DISEASE, vol. 11, no. 2, November 2002 (2002-11-01), pages 315 - 329, XP002310403, ISSN: 0969-9961
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