Title:
AMYOTROPHIC LATERAL SCLEROSIS DIAGNOSTIC METHOD USING SIGNAL PEPTIDE AS INDEX
Document Type and Number:
WIPO Patent Application WO/2017/150681
Kind Code:
A1
Abstract:
This method assists in the detection of ALS and involves determining the profile of signal peptides contained in a bodily fluid derived from a subject being examined, and comparing said determined signal peptide profile of the subject being examined with the profile of signal peptides in the bodily fluid derived from a pre-determined healthy subject. Further, this method is characterized in that a difference at a specific molecular weight between the signal peptide profile of the subject being examined and the signal peptide profile of the healthy subject is associated with the subject being examined suffering from or developing ALS.
Inventors:
BAILEYKOBAYASHI NAHOKO (JP)
SAWADA MAKOTO (JP)
YOSHIDA TETSUHIKO (JP)
SAWADA MAKOTO (JP)
YOSHIDA TETSUHIKO (JP)
Application Number:
PCT/JP2017/008332
Publication Date:
September 08, 2017
Filing Date:
March 02, 2017
Export Citation:
Assignee:
TOAGOSEI CO LTD (JP)
NAT UNIV CORP NAGOYA UNIV (JP)
NAT UNIV CORP NAGOYA UNIV (JP)
International Classes:
G01N27/62; G01N33/68; C07K7/00
Domestic Patent References:
| WO2005042761A2 | 2005-05-12 | |||
| WO2015178249A1 | 2015-11-26 | |||
| WO2016032319A1 | 2016-03-03 |
Foreign References:
| US20050244904A1 | 2005-11-03 |
Other References:
B UTTERFIELD,D.A.: "MASS SPECTROMETRY AND REDOX PROTEOMICS: APPLICATIONS IN DISEASE", MASS SPECTROMETRY REVIEWS, vol. 33, no. 4, 2014, pages 277 - 301, XP055414964
Attorney, Agent or Firm:
ABE Makoto (JP)
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