ANALGESIC ACTIVITY ENHANCER - OTSUKA PHARMA CO LTD

Title:

ANALGESIC ACTIVITY ENHANCER

Document Type and Number:

WIPO Patent Application WO/1995/022967

Kind Code:

A1

Abstract:

An analgesic activity enhancer containing as the active ingredient (in terms of free amino acid expressed in wt.%) leucine (8.0 - 16.0), isoleucine (4.0 - 9.0), valine (4.0 - 9.0), lysine (6.0 - 13.0), threonine (3.0 - 6.0), tryptophan (1.0 - 2.0), methionine (2.0 - 5.0), cysteine (0.5 - 2.0), phenylalanine (3.0 - 7.0), tyrosine (0.2 - 1.0), histidine (2.0 - 5.0), arginine (30.0 - 60.0), alanine (0.5 - 2.0), aminoacetic acid (0.5 - 2.0), serine (0.2 - 1.0), proline (0.5 - 2.0), aspartic acid (0.1 - 0.5), and glutamic acid (0.1 - 0.5). It can remarkably enhance the analgesic activities of various analgesics.

Inventors:

MUKAI KIYOSHI (JP)
KOHRI HIDEAKI (JP)

Application Number:

PCT/JP1995/000155

Publication Date:

August 31, 1995

Filing Date:

February 07, 1995

Export Citation:

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Assignee:

OTSUKA PHARMA CO LTD (JP)
MUKAI KIYOSHI (JP)
KOHRI HIDEAKI (JP)

International Classes:

A61K31/415; A61K31/485; (IPC1-7): A61K31/195; A61K31/40; A61K31/405; A61K31/415

Foreign References:

EP0424028A2	1991-04-24
DE4420858A1	1994-12-22
JPH01301619A	1989-12-05

Other References: