Title:
ANALGESIC DRUG USING NR4A1 ANTAGONIST
Document Type and Number:
WIPO Patent Application WO/2022/014433
Kind Code:
A1
Abstract:
The present invention pertains to: a compound represented by formula (I) (in the formula, R1 represents a hydroxyl group, a mercapto group, a C1-6-alkoxy group, a C1-6-haloalkoxy group, an amino group, a C1-6-alkyl amino group, or a di-C1-6-alkyl amino group, R2 represents a hydroxyl group, a mercapto group, a C1-6-alkoxy group, a C1-6-haloalkoxy group, an amino group, a C1-6-alkyl amino group, or a di-C1-6-alkyl amino group, R3 represents a halogen atom, a nitro group, a carboxyl group, a C1-6-alkoxy-carbonyl group, or a carboxy-C1-6-alkyl group, and R4 represents a substituted or unsubstituted C3-12-hydrocarbon group) or a salt thereof, or a solvate thereof; and an analgesic drug that contains the compound or a salt thereof, or a solvate thereof.
Inventors:
TAKASAKI ICHIRO (JP)
TOYOOKA NAOKI (JP)
OKADA TAKUYA (JP)
KURIHARA TAKASHI (JP)
GOUDA HIROAKI (JP)
TOYOOKA NAOKI (JP)
OKADA TAKUYA (JP)
KURIHARA TAKASHI (JP)
GOUDA HIROAKI (JP)
Application Number:
PCT/JP2021/025590
Publication Date:
January 20, 2022
Filing Date:
July 07, 2021
Export Citation:
Assignee:
NATIONAL UNIV CORPORATION UNIV OF TOYAMA (JP)
UNIV KAGOSHIMA (JP)
UNIV SHOWA (JP)
UNIV KAGOSHIMA (JP)
UNIV SHOWA (JP)
International Classes:
A61P29/00; A61K31/517; A61P35/00; C07D239/91
Other References:
DATABASE REGISTRY 05/07/2015, ANONYMOUS : "/1 -(C) FILE REGISTRY RN -1795010-99-9 REGISTRY ED -Entered STN: 05 Jul 2015 CN -4(1H)-Quinazolinone, 2-(3-chloro-4,5-dihydroxyphenyl)-2,3-dihydro-3-(2- methylpropyl)-(CA INDEX NAME) ", XP055900327, retrieved from STN Database accession no. 1795010-99-9
DATABASE REGISTRY 09/09/2011, ANONYMOUS : "/1 -(C) FILE REGISTRY RN -1330600-74-2 REGISTRY ED -Entered STN: 09 Sep 2011 CN -4(1H)-Quinazolinone, 2-(3-chloro-4,5-dihydroxyphenyl)-2,3-dihydro-3-propyl- (CA INDEX NAME) ", XP055900345, retrieved from STN Database accession no. 1330600-74-2
DATABASE Registy 1 September 2011 (2011-09-01), ANONYMOUS : "2-(3-chloro-4,5-dihydroxyphenyl)-2,3-dihydro-3-(2-propen-1-yl)- 4(lH)-Quinazolinone", XP055903523, retrieved from STN Database accession no. 1326463-27-7
DATABASE Registry 1 March 2007 (2007-03-01), ANONYMOUS : "2-(3-chloro-4-hydroxy-5-methoxyphenyl)-2,3-dihydro-3-propyl-4(1H)- Quinazolinone", XP055903531, retrieved from STN Database accession no. 924105-05-5
DATABASE Registry 25 February 2009 (2009-02-25), ANONYMOUS : "2-(3-chloro-5-ethoxy-4-hydroxyphenyl)-2,3-dihydro-3-(2-me thylpropyl)-4(lH)-Quinazolinone", XP055903548, retrieved from STN Database accession no. 1111451-36-5
DATABASE Registry 27 June 2008 (2008-06-27), ANONYMOUS : "4(1H)-Quinazolinone, 2-(3-bromo-5-ethoxy-4-methoxyphenyl)-2,3-dihydro-3-propyl-", XP055903536, retrieved from STN Database accession no. 1031169-80-8
DATABASE Registry 10 April 2008 (2008-04-10), ANONYMOUS : "2-(3-chloro-4-hydroxy-5-methoxyphenyl)-2,3-dihydro-3-(2-propen-1- yl)-4(1H)-Quinazol inone", XP055903546, retrieved from STN Database accession no. 1013582-50-7
DATABASE Registry 27 April 2011 (2011-04-27), ANONYMOUS : "2-(3-chloro-4,5-dimethoxyphenyl)-2,3-dihydro-3-(2-propen-1-yl)- 4(1H)-Quinazol inone", XP055903551, retrieved from STN Database accession no. 1286441-93-7
DATABASE Registry 10 April 2008 (2008-04-10), ANONYMOUS : "2-(3-chloro-4-ethoxy-5-methoxyphenyl)-2,3-dihydro-3-(2-propen-l- yl)- 4(IH)-Quinazolinone", XP055903552, retrieved from STN Database accession no. 1013308-53-6
DATABASE Registry 10 April 2008 (2008-04-10), ANONYMOUS : "2-(3-chloro-5-ethoxy-4-methoxyphenyl)-2,3-dihydro-3-(2-propen-1- yl)-4(1H)-Quinazol inone", XP055903575, retrieved from STN Database accession no. 1013582-58-5
DATABASE Registry 4 March 2018 (2018-03-04), ANONYMOUS : "2-(3-chloro-5-methoxy-4-propoxyphenyl)-2,3-dihydro-3-(2-propen-1- yl)-4(1H)-Quinazol inone", XP055903581, retrieved from STN Database accession no. 2184216-83-7
DATABASE Registry 10 April 2008 (2008-04-10), ANONYMOUS : "2-(3-bromo-4-ethoxy-5-methoxyphenyl)-2,3-dihydro-3-(2- propen- 1-yl)-4(1H)-Quinazolinone, 2-(3-bromo-4-ethoxy-5-methoxyphenyl)-2,3- dihydro-3-(2-propen-1-yl)-4(1H)-Quinazol inone", XP055903584, retrieved from STN Database accession no. 1013494-30-8
DATABASE Registry 26 January 2009 (2009-01-26), ANONYMOUS : "2-(3-bromo-5-ethoxy-4-methoxyphenyl)-2,3-dihydro-3-(2-propen-l- yl)-4(1H)-Quinazol inone", XP055903586, retrieved from STN Database accession no. 1095838-76-8
DATABASE REGISTRY 09/09/2011, ANONYMOUS : "/1 -(C) FILE REGISTRY RN -1330600-74-2 REGISTRY ED -Entered STN: 09 Sep 2011 CN -4(1H)-Quinazolinone, 2-(3-chloro-4,5-dihydroxyphenyl)-2,3-dihydro-3-propyl- (CA INDEX NAME) ", XP055900345, retrieved from STN Database accession no. 1330600-74-2
DATABASE Registy 1 September 2011 (2011-09-01), ANONYMOUS : "2-(3-chloro-4,5-dihydroxyphenyl)-2,3-dihydro-3-(2-propen-1-yl)- 4(lH)-Quinazolinone", XP055903523, retrieved from STN Database accession no. 1326463-27-7
DATABASE Registry 1 March 2007 (2007-03-01), ANONYMOUS : "2-(3-chloro-4-hydroxy-5-methoxyphenyl)-2,3-dihydro-3-propyl-4(1H)- Quinazolinone", XP055903531, retrieved from STN Database accession no. 924105-05-5
DATABASE Registry 25 February 2009 (2009-02-25), ANONYMOUS : "2-(3-chloro-5-ethoxy-4-hydroxyphenyl)-2,3-dihydro-3-(2-me thylpropyl)-4(lH)-Quinazolinone", XP055903548, retrieved from STN Database accession no. 1111451-36-5
DATABASE Registry 27 June 2008 (2008-06-27), ANONYMOUS : "4(1H)-Quinazolinone, 2-(3-bromo-5-ethoxy-4-methoxyphenyl)-2,3-dihydro-3-propyl-", XP055903536, retrieved from STN Database accession no. 1031169-80-8
DATABASE Registry 10 April 2008 (2008-04-10), ANONYMOUS : "2-(3-chloro-4-hydroxy-5-methoxyphenyl)-2,3-dihydro-3-(2-propen-1- yl)-4(1H)-Quinazol inone", XP055903546, retrieved from STN Database accession no. 1013582-50-7
DATABASE Registry 27 April 2011 (2011-04-27), ANONYMOUS : "2-(3-chloro-4,5-dimethoxyphenyl)-2,3-dihydro-3-(2-propen-1-yl)- 4(1H)-Quinazol inone", XP055903551, retrieved from STN Database accession no. 1286441-93-7
DATABASE Registry 10 April 2008 (2008-04-10), ANONYMOUS : "2-(3-chloro-4-ethoxy-5-methoxyphenyl)-2,3-dihydro-3-(2-propen-l- yl)- 4(IH)-Quinazolinone", XP055903552, retrieved from STN Database accession no. 1013308-53-6
DATABASE Registry 10 April 2008 (2008-04-10), ANONYMOUS : "2-(3-chloro-5-ethoxy-4-methoxyphenyl)-2,3-dihydro-3-(2-propen-1- yl)-4(1H)-Quinazol inone", XP055903575, retrieved from STN Database accession no. 1013582-58-5
DATABASE Registry 4 March 2018 (2018-03-04), ANONYMOUS : "2-(3-chloro-5-methoxy-4-propoxyphenyl)-2,3-dihydro-3-(2-propen-1- yl)-4(1H)-Quinazol inone", XP055903581, retrieved from STN Database accession no. 2184216-83-7
DATABASE Registry 10 April 2008 (2008-04-10), ANONYMOUS : "2-(3-bromo-4-ethoxy-5-methoxyphenyl)-2,3-dihydro-3-(2- propen- 1-yl)-4(1H)-Quinazolinone, 2-(3-bromo-4-ethoxy-5-methoxyphenyl)-2,3- dihydro-3-(2-propen-1-yl)-4(1H)-Quinazol inone", XP055903584, retrieved from STN Database accession no. 1013494-30-8
DATABASE Registry 26 January 2009 (2009-01-26), ANONYMOUS : "2-(3-bromo-5-ethoxy-4-methoxyphenyl)-2,3-dihydro-3-(2-propen-l- yl)-4(1H)-Quinazol inone", XP055903586, retrieved from STN Database accession no. 1095838-76-8
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
Download PDF:
Previous Patent: FILTER CIRCUIT, AND POWER SUPPLY DEVICE INCLUDING SAME
Next Patent: ALIPHATIC-AROMATIC POLYESTER RESIN AND MOLDED ITEM THEREOF
Next Patent: ALIPHATIC-AROMATIC POLYESTER RESIN AND MOLDED ITEM THEREOF