Title:
ANALGESIC EFFECTS OF PEPTIDE TOXIN APETX2
Document Type and Number:
WIPO Patent Application WO/2009/147326
Kind Code:
A8
Abstract:
The invention relates to the use of the peptide toxin APETx2 that blocks the ASIC3 cationic channels and that is derived from the Anthopleura elegantissima sea anemone, and to the use of the analogs and derivatives thereof as a drug, particularly as an analgesic against pain associated with the activation of ASIC3 (Acid Sensing Ion Channel 3) channels, in particular pain occurring upon an inflammation and potentially upon any painful situation associated with tissue acidosis (ischemiae, fractures, hematoma, oedema, phlyctena, local infections, tissue lesions, ocular wounds, tumours, etc.)
Inventors:
DEVAL EMMANUEL (FR)
DIOCHOT SYLVIE (FR)
LAZDUNSKI MICHEL (FR)
LINGUEGLIA ERIC (FR)
NOEL JACQUES (FR)
DIOCHOT SYLVIE (FR)
LAZDUNSKI MICHEL (FR)
LINGUEGLIA ERIC (FR)
NOEL JACQUES (FR)
Application Number:
PCT/FR2009/000657
Publication Date:
December 09, 2010
Filing Date:
June 04, 2009
Export Citation:
Assignee:
CENTRE NAT RECH SCIENT (FR)
UNIV NICE SOPHIA ANTIPOLIS (FR)
DEVAL EMMANUEL (FR)
DIOCHOT SYLVIE (FR)
LAZDUNSKI MICHEL (FR)
LINGUEGLIA ERIC (FR)
NOEL JACQUES (FR)
UNIV NICE SOPHIA ANTIPOLIS (FR)
DEVAL EMMANUEL (FR)
DIOCHOT SYLVIE (FR)
LAZDUNSKI MICHEL (FR)
LINGUEGLIA ERIC (FR)
NOEL JACQUES (FR)
International Classes:
A61K38/16; A61P17/04; A61P29/00
Attorney, Agent or Firm:
NOVAGRAAF TECHNOLOGIES (Levallois-Perret Cedex, FR)
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