Title:
ANALYSIS METHOD AND PRETREATMENT APPARATUS
Document Type and Number:
WIPO Patent Application WO/2022/215749
Kind Code:
A1
Abstract:
In this analysis system (1000), a pretreatment apparatus (400) causes a sample (a sample based on a metabolite of a subject) relating to a metabolic disorder to react with a reagent. The reagent contains 3-nitrophenylhydrazine. An organic acid contained in the sample is derivatized by the reaction of the sample with the reagent. The pretreatment apparatus (400) transports a sample containing the derivatized organic acid to an LC mass spectrometer (100). The LC mass spectrometer (100) analyzes the transported sample.
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Inventors:
KAWAKAMI DAISUKE (JP)
SETOYAMA DAIKI (JP)
KANG DONGCHON (JP)
UEYANAGI YASUSHI (JP)
SETOYAMA DAIKI (JP)
KANG DONGCHON (JP)
UEYANAGI YASUSHI (JP)
Application Number:
PCT/JP2022/017358
Publication Date:
October 13, 2022
Filing Date:
April 08, 2022
Export Citation:
Assignee:
SHIMADZU CORP (JP)
UNIV KYUSHU NAT UNIV CORP (JP)
UNIV KYUSHU NAT UNIV CORP (JP)
International Classes:
G01N27/62; G01N30/72; G01N33/50; H01J49/00; H01J49/26
Foreign References:
| JP2020517929A | 2020-06-18 | |||
| US20120295295A1 | 2012-11-22 |
Other References:
ANONYMOUS: "Manual for Development of Chemical Substance Analysis Methods Using LC/MS", 1 January 2001 (2001-01-01), pages 79 - 95, XP055975599, Retrieved from the Internet [retrieved on 20221027]
TOMIKO KUHARA: "Japanese Journal of Hygiene", vol. 69, 2014, THE JAPANESE SOCIETY FOR HYGIENE, article "Present Status of Expanded Newborn Screening Project for Inborn Errors of Metabolism by Tandem Mass Spectrometry", pages: 60 - 74
TOMIKO KUHARA: "Japanese Journal of Hygiene", vol. 69, 2014, THE JAPANESE SOCIETY FOR HYGIENE, article "Present Status of Expanded Newborn Screening Project for Inborn Errors of Metabolism by Tandem Mass Spectrometry", pages: 60 - 74
Attorney, Agent or Firm:
FUKAMI PATENT OFFICE, P.C. (JP)
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