Title:
ANALYSIS OF MICROBIAL FRAGMENTS IN PLASMA
Document Type and Number:
WIPO Patent Application WO/2024/007971
Kind Code:
A1
Abstract:
Various embodiments are directed to detecting infection-causing microbial cell-free DNA from a biological sample based on their size profiles and/or end signatures, in which the detection of infection-causing microbial DNA can be performed without no template control (NTC) samples. Embodiments can include identifying the infection-causing pathogen-derived microbial DNA based on sizes of microbial cell-free DNA molecules. Embodiments can also include identifying from the infection-causing pathogen-derived microbial DNA based on end signatures of microbial cell-free DNA molecules. Embodiments can also include applying a machine-learning algorithm to a plurality of vectors that represent end signatures of the microbial cell-free DNA molecules, to identify the infection-causing pathogen-derived microbial DNA. By detecting the infection-causing pathogen-derived microbial DNA, a level of infection for the biological sample can be predicted.
Inventors:
LO YUK-MING (CN)
CHAN KWAN CHEE (CN)
CHIU ROSSA WAI KWUN (CN)
LAM WAI KEI (CN)
JIANG PEIYONG (CN)
WANG GUANGYA (CN)
CHAN KWAN CHEE (CN)
CHIU ROSSA WAI KWUN (CN)
LAM WAI KEI (CN)
JIANG PEIYONG (CN)
WANG GUANGYA (CN)
Application Number:
PCT/CN2023/104320
Publication Date:
January 11, 2024
Filing Date:
June 30, 2023
Export Citation:
Assignee:
UNIV HONG KONG CHINESE (CN)
GRAIL LLC (US)
GRAIL LLC (US)
International Classes:
C12Q1/6886; C12Q1/68; C12Q1/70; G16B20/00
Domestic Patent References:
| WO2022012504A1 | 2022-01-20 |
Foreign References:
| CN110291212A | 2019-09-27 | |||
| CN108026572A | 2018-05-11 | |||
| US20210238668A1 | 2021-08-05 | |||
| CN112292458A | 2021-01-29 | |||
| US20200199656A1 | 2020-06-25 |
Attorney, Agent or Firm:
INSIGHT INTELLECTUAL PROPERTY LIMITED (CN)
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