Title:
ANGIOGENESIS INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2017/090157
Kind Code:
A1
Abstract:
Provided is an angiogenesis inhibitor effective in the prevention of angiogenesis that becomes the cause of disease, the angiogenesis inhibitor is produced by, for instance, performing sterile filtration, disinfection, and concentration of a product in which biological decoration was carried out in a water-soluble polysaccharide extract, by: adding a water-soluble polysaccharide extract which is obtained by extracting bran with hot water, filtering the insoluble matter, and treating the filtrate with glucoamylase to decompose the starch, and an enzyme compound obtained from the precipitate resulting from adding ammonium sulfate to a culture filtrate obtained by culture of the basidiomycetes Lentinula edodes; and reacting the foregoing mixture for 30 to 60 minutes at a pH of 4.5, and then further reacting the foregoing mixture for 30 to 60 minutes at a pH of 6.0.
Inventors:
ZHU XIA (JP)
IGARI NAOKI (JP)
IGARI NAOKI (JP)
Application Number:
PCT/JP2015/083238
Publication Date:
June 01, 2017
Filing Date:
November 26, 2015
Export Citation:
Assignee:
DAIWA PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K36/899; A61K31/715; A61P9/00; A61P35/00
Foreign References:
| JPH0923895A | 1997-01-28 |
Other References:
GHONEUM,MAMDOOH ET AL.: "Modified arabinoxylan from rice bran, MGN-3/Biobran, sensitizes metastatic breast cancer cells to paclitaxel in Vitro", ANTICANCER RESEARCH, vol. 34, no. 1, 2014, pages 81 - 87, XP055487983
HIROAKI YAZAMA ET AL.: "Komenuka Yurai Glucosylceramide no Ko-Shuyo Koka to Kekkan Shinsei eno Eikyo", JAPANESE JOURNAL OF HEAD AND NECK CANCER, vol. 38, no. 2, 2012, pages 226 , 357, XP009506707
J. FOLKMAN: "Angiogenesis in cancer, vascular, rheumatoid and other disease", NATURE MEDICINE, vol. 1, 1995, pages 27 - 31, XP000605147, DOI: doi:10.1038/nm0195-27
N. FERRARA: "Role of vascular endothelial growth factor in the regulation of angiogenesis", KIDNEY INTERNATIONAL, vol. 56, 1999, pages 794 - 814
See also references of EP 3381460A4
HIROAKI YAZAMA ET AL.: "Komenuka Yurai Glucosylceramide no Ko-Shuyo Koka to Kekkan Shinsei eno Eikyo", JAPANESE JOURNAL OF HEAD AND NECK CANCER, vol. 38, no. 2, 2012, pages 226 , 357, XP009506707
J. FOLKMAN: "Angiogenesis in cancer, vascular, rheumatoid and other disease", NATURE MEDICINE, vol. 1, 1995, pages 27 - 31, XP000605147, DOI: doi:10.1038/nm0195-27
N. FERRARA: "Role of vascular endothelial growth factor in the regulation of angiogenesis", KIDNEY INTERNATIONAL, vol. 56, 1999, pages 794 - 814
See also references of EP 3381460A4
Attorney, Agent or Firm:
YAMAKAWA,Masaki et al. (JP)
Download PDF: