Title:
ANIMAL MODEL FOR OBESITY INDEPENDENTLY OF INSULIN RESISTANCE
Document Type and Number:
WIPO Patent Application WO2004064714
Kind Code:
A3
Abstract:
The invention provides a method for identifying a candidate compound or compounds capable of modulating factors which influence obesity independently of insulin resistance, comprising administering the compound or compounds to a transgenic non-human SLOB animal expressing, as a result of transgene expression, a 5'OT-EST polypeptide or mutant 5'OT-EST polypeptide.
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Inventors:
ROBINSON IAIN (GB)
LETISSIER PAUL (GB)
BAINS RANDIP (GB)
STROM MOLLY (GB)
LETISSIER PAUL (GB)
BAINS RANDIP (GB)
STROM MOLLY (GB)
Application Number:
PCT/GB2004/000168
Publication Date:
October 07, 2004
Filing Date:
January 20, 2004
Export Citation:
Assignee:
MEDICAL RES COUNCIL (GB)
ROBINSON IAIN (GB)
LETISSIER PAUL (GB)
BAINS RANDIP (GB)
STROM MOLLY (GB)
ROBINSON IAIN (GB)
LETISSIER PAUL (GB)
BAINS RANDIP (GB)
STROM MOLLY (GB)
International Classes:
A01K67/027; A61K49/00; C07K14/47; C12N15/85; G01N33/50; (IPC1-7): G01N33/50; A01K67/027; C07K14/47
Domestic Patent References:
| WO2000009686A1 | 2000-02-24 |
Other References:
KAHN B B ET AL: "Obesity and insulin resistance", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 106, no. 4, August 2000 (2000-08-01), pages 473 - 481, XP002231945, ISSN: 0021-9738
BAINS R K ET AL: "Transgenic SLOB rats showing Severe Late-onset male-specific visceral obesity", JOURNAL OF ENDOCRINOLOGY, vol. 164, no. Suppl., March 2000 (2000-03-01), & 19TH JOINT MEETING OF THE BRITISH ENDOCRINE SOCIETIES, WITH THE EUROPEAN FEDERATION OF ENDOCRINE SO; BIRMINGHAM, ENGLAND, UK; MARCH 13-16, 2000, pages P201, XP008030956, ISSN: 0022-0795
WELLS SARA E ET AL: "Transgenesis and neuroendocrine physiology: A transgenic rat model expressing growth hormone in vasopressin neurones.", JOURNAL OF PHYSIOLOGY (CAMBRIDGE), vol. 551, no. 1, 15 August 2003 (2003-08-15), pages 323 - 336, XP002281391, ISSN: 0022-3751
BAINS R K ET AL: "Transgenic SLOB rats showing Severe Late-onset male-specific visceral obesity", JOURNAL OF ENDOCRINOLOGY, vol. 164, no. Suppl., March 2000 (2000-03-01), & 19TH JOINT MEETING OF THE BRITISH ENDOCRINE SOCIETIES, WITH THE EUROPEAN FEDERATION OF ENDOCRINE SO; BIRMINGHAM, ENGLAND, UK; MARCH 13-16, 2000, pages P201, XP008030956, ISSN: 0022-0795
WELLS SARA E ET AL: "Transgenesis and neuroendocrine physiology: A transgenic rat model expressing growth hormone in vasopressin neurones.", JOURNAL OF PHYSIOLOGY (CAMBRIDGE), vol. 551, no. 1, 15 August 2003 (2003-08-15), pages 323 - 336, XP002281391, ISSN: 0022-3751
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