Title:
ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS
Document Type and Number:
WIPO Patent Application WO/2010/077882
Kind Code:
A3
Abstract:
Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
Inventors:
HUTCHINSON JOHN HOWARD (US)
SEIDERS THOMAS JON (US)
WANG BOWEI (US)
ARRUDA JEANNIE M (US)
ROPPE JEFFREY ROGER (US)
PARR TIMOTHY (US)
ZHAO LUCY (US)
SEIDERS THOMAS JON (US)
WANG BOWEI (US)
ARRUDA JEANNIE M (US)
ROPPE JEFFREY ROGER (US)
PARR TIMOTHY (US)
ZHAO LUCY (US)
Application Number:
PCT/US2009/068105
Publication Date:
October 28, 2010
Filing Date:
December 15, 2009
Export Citation:
Assignee:
AMIRA PHARMACEUTICALS INC (US)
HUTCHINSON JOHN HOWARD (US)
SEIDERS THOMAS JON (US)
WANG BOWEI (US)
ARRUDA JEANNIE M (US)
ROPPE JEFFREY ROGER (US)
PARR TIMOTHY (US)
ZHAO LUCY (US)
HUTCHINSON JOHN HOWARD (US)
SEIDERS THOMAS JON (US)
WANG BOWEI (US)
ARRUDA JEANNIE M (US)
ROPPE JEFFREY ROGER (US)
PARR TIMOTHY (US)
ZHAO LUCY (US)
International Classes:
C07D413/10; A61K31/553; A61P11/06; C07D261/06; C07D413/06
Domestic Patent References:
| WO2001060819A1 | 2001-08-23 | |||
| WO2005012269A1 | 2005-02-10 |
Foreign References:
| JP2006096712A | 2006-04-13 |
Other References:
YAMAMOTO,T. ET AL.: "Synthesis and evaluation of isoxazole derivatives as lysophosphatidic acid(LPA) antagonists", BIOORGANIC&MEDICINAL CHEMISTRY LETTERS, vol. 17, no. 13, 2007, pages 3736 - 3740
Attorney, Agent or Firm:
AKHAVAN, Ramin et al. (650 Page Mill RoadPalo Alto, California, US)
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