Title:
ANTI-ACNE FORMULATIONS CONTAINING A DIALKYL SULPHOSUCCINATE AND SALICYLIC ACID
Document Type and Number:
WIPO Patent Application WO/2011/001165
Kind Code:
A3
Abstract:
Anti-acne formulation containing (i) 3.5% w/v or greater of a dialkyl sulpho succinate (DAS) such as a dioctyl sulpho succinate and (ii) salicylic acid or a derivative thereof (other than a halogenated salicylanilide), which is suitable for application as a topical leave-on formulation. The salicylic acid or derivative may be present at a concentration of 0.5% w/w. The formulation may contain, in addition to the DAS and the salicylic acid or derivative, (a) a polyoxyalkylene-based solubilising agent and (b) an organic solvent, in particular an alcohol, optionally together with a thickening agent and/or water. It may contain an antioxidant such as AO 2246 or AO 425. It may be applied once daily over a period of several weeks.
Inventors:
JONES STEPHEN PHILIP (GB)
FITZGERALD DANIEL JAMES (GB)
SEVILLE SCOTT (GB)
PAKUNLU REFIKA I (US)
DESAI NAYAN N (US)
DAVIS ADRIAN (GB)
FITZGERALD DANIEL JAMES (GB)
SEVILLE SCOTT (GB)
PAKUNLU REFIKA I (US)
DESAI NAYAN N (US)
DAVIS ADRIAN (GB)
Application Number:
PCT/GB2010/051038
Publication Date:
June 23, 2011
Filing Date:
June 23, 2010
Export Citation:
Assignee:
SYNTOPIX GROUP PLC (GB)
JONES STEPHEN PHILIP (GB)
FITZGERALD DANIEL JAMES (GB)
SEVILLE SCOTT (GB)
PAKUNLU REFIKA I (US)
DESAI NAYAN N (US)
DAVIS ADRIAN (GB)
JONES STEPHEN PHILIP (GB)
FITZGERALD DANIEL JAMES (GB)
SEVILLE SCOTT (GB)
PAKUNLU REFIKA I (US)
DESAI NAYAN N (US)
DAVIS ADRIAN (GB)
International Classes:
A61K31/225; A61K31/60; A61P31/04
Domestic Patent References:
| WO2008146030A1 | 2008-12-04 | |||
| WO2000006116A1 | 2000-02-10 |
Other References:
EADY E A ET AL: "The benefit of 2% salicylic acid lotion in acne - A placebo-controlled study", JOURNAL OF DERMATOLOGICAL TREATMENT, BASINGSTOKE, GB, vol. 7, no. 2, 1 January 1996 (1996-01-01), pages 93 - 96, XP008123509, ISSN: 0954-6634
"A novel salicylic acid topical acne treatment rapidly improves mild to moderate acne lesions", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, C.V. MOSBY, ST. LOUIS, MO, US, vol. 52, no. 3, 1 March 2005 (2005-03-01), pages P11, XP004840244, ISSN: 0190-9622
"Efficacy and safety of a new salicylic acid derivative (LHA) alone or as a complement of tretinoin in acne treatment", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, C.V. MOSBY, ST. LOUIS, MO, US, vol. 56, no. 2, 1 February 2007 (2007-02-01), pages AB15, XP005936730, ISSN: 0190-9622
"Pharmacology of salicylic acid (SA) in acne vulgaris", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, C.V. MOSBY, ST. LOUIS, MO, US, vol. 56, no. 2, 1 February 2007 (2007-02-01), pages AB22, XP005936755, ISSN: 0190-9622
"A novel salicylic acid topical acne treatment rapidly improves mild to moderate acne lesions", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, C.V. MOSBY, ST. LOUIS, MO, US, vol. 52, no. 3, 1 March 2005 (2005-03-01), pages P11, XP004840244, ISSN: 0190-9622
"Efficacy and safety of a new salicylic acid derivative (LHA) alone or as a complement of tretinoin in acne treatment", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, C.V. MOSBY, ST. LOUIS, MO, US, vol. 56, no. 2, 1 February 2007 (2007-02-01), pages AB15, XP005936730, ISSN: 0190-9622
"Pharmacology of salicylic acid (SA) in acne vulgaris", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, C.V. MOSBY, ST. LOUIS, MO, US, vol. 56, no. 2, 1 February 2007 (2007-02-01), pages AB22, XP005936755, ISSN: 0190-9622
Attorney, Agent or Firm:
BREWSTER, Andrea (Indigo HouseCheddar Business Park,Wedmore Road, Cheddar Somerset BS27 3EB, GB)
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