Title:
ANTI-ADHESION COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2019/138583
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an anti-adhesion material having a high anti-adhesion effect. The present invention pertains to an anti-adhesion material comprising a biocompatible sponge-like layered body having a sponge-like first layer and a sponge-like second layer both being at least partially crosslinked with a curing agent and comprising a monovalent metal salt of low endotoxin alginic acid. The monovalent metal salt of alginic acid in the first layer has a weight average molecular weight of 30000 to 300000. The monovalent metal salt of alginic acid in the second layer has a weight average molecular weight of 1000 to 200000. The weight average molecular weights are determined by GPC-MALS after a de-crosslinking treatment. The weight average molecular weight of the monovalent metal salt of alginic acid in the first layer is higher than the weight average molecular weight of the monovalent metal salt of alginic acid in the second layer.
Inventors:
ITO TAICHI (JP)
OHTA SEIICHI (JP)
HASEGAWA KIYOSHI (JP)
ISAJI MITSUKO (JP)
SHIMIZU SATOSHI (JP)
TANAKA DAICHI (JP)
OHTA SEIICHI (JP)
HASEGAWA KIYOSHI (JP)
ISAJI MITSUKO (JP)
SHIMIZU SATOSHI (JP)
TANAKA DAICHI (JP)
Application Number:
PCT/JP2018/000874
Publication Date:
July 18, 2019
Filing Date:
January 15, 2018
Export Citation:
Assignee:
MOCHIDA PHARM CO LTD (JP)
UNIV TOKYO (JP)
UNIV TOKYO (JP)
International Classes:
A61L31/04; A61L31/12; B32B5/32; B32B27/00; B32B27/26
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Other References:
NAMBA J. ET AL.: "Modulation of peritendinous adhesion formation by alginate solution in a rabbit flexor tendon model.", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART B, APPLIED BIOMATERIALS, vol. 80, no. 1, 2007, pages 273 - 279, XP055602314, ISSN: 1552-4973, doi:10.1002/jbm.b.30594
CHATURVEDI, A. A. ET AL.: "Prevention of postsurgical adhesions using an ultrapure alginate-based gel.", BRITISH JOURNAL OF SURGERY, vol. 100, no. 7, 2013, pages 904 - 910, XP055296836, ISSN: 0007-1323, doi:10.1002/bjs.9131
APPL MICROBIOL BIOTECHNOL, vol. 40, 1994, pages 638 - 643
SHIMIZU A ET AL., SURG TODAY, vol. 44, 2014, pages 314 - 323
CHATURVEDI, A. A. ET AL.: "Prevention of postsurgical adhesions using an ultrapure alginate-based gel.", BRITISH JOURNAL OF SURGERY, vol. 100, no. 7, 2013, pages 904 - 910, XP055296836, ISSN: 0007-1323, doi:10.1002/bjs.9131
APPL MICROBIOL BIOTECHNOL, vol. 40, 1994, pages 638 - 643
SHIMIZU A ET AL., SURG TODAY, vol. 44, 2014, pages 314 - 323
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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