Title:
ANTI-ADHESIVE MATERIAL, AND METHOD FOR PRODUCING ANTI-ADHESIVE MATERIAL
Document Type and Number:
WIPO Patent Application WO/2023/181563
Kind Code:
A1
Abstract:
Provided is an anti-adhesive material containing particles, in which the particles comprise a crosslinked product of a gelatin mixture composed of a first gelatin and a second gelatin having such a structure that a hydrocarbon group is introduced into the first gelatin, the ratio of the introduction of hydrocarbon groups in the gelatin mixture is 30 mol% to 50 mol%, and the second gelatin has a structure represented by formula (1). The anti-adhesive material has excellent adhesiveness on a tissue and excellent adhesion stability under an aqueous environment, has an easy operability, and is easy to be produced on an industrially large scale. In formula (1), Gltn represents a residue of gelatin; L represents a single bond or a bivalent linking group; R1 represents an alkyl group having 1 to 20 carbon atoms; and R2 represents a hydrogen atom or an alkyl group having 1 to 20 carbon atoms.
Inventors:
TAGUCHI TETSUSHI (JP)
Application Number:
PCT/JP2022/047729
Publication Date:
September 28, 2023
Filing Date:
December 23, 2022
Export Citation:
Assignee:
NAT INST MATERIALS SCIENCE (JP)
International Classes:
A61K9/14; A61L31/04; A61K38/39; A61L15/32; A61P7/04; A61P17/02; A61P41/00
Domestic Patent References:
| WO2020137903A1 | 2020-07-02 | |||
| WO2020050102A1 | 2020-03-12 | |||
| WO2019045081A1 | 2019-03-07 |
Other References:
MIZUNO, YOSUKE ET AL.: "Tissue-sealing and anti-adhesion properties of an in situ hydrogel of hydrophobically-modified Alaska pollock-derived gelatin", INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, vol. 163, 2020, pages 2365 - 2373, XP086300432, DOI: 10.1016/j.ijbiomac.2020.09.084
NISHIGUCHI, AKIHIRO ET AL.: "Underwater-adhesive microparticle dressing composed of hydrophobically-modified Alaska pollock gelatin for gastrointestinal tract wound healing", ACTA BIOMATERIALIA, vol. 99, 2019, pages 387 - 396, XP085897096, DOI: 10.1016/j.actbio.2019.08.040
NISHIGUCHI AKIHIRO, KURIHARA YUKARI, TAGUCHI TETSUSHI: "Hemostatic, Tissue-Adhesive Colloidal Wound Dressing Functionalized by UV Irradiation", ACS APPLIED BIO MATERIALS, AMERICAN CHEMICAL SOCIETY, US, vol. 3, no. 3, 16 March 2020 (2020-03-16), US , pages 1705 - 1711, XP093094854, ISSN: 2576-6422, DOI: 10.1021/acsabm.0c00015
MIZUTA, RYO ET AL.: "Evaluation of an octyl group-modified Alaska pollock gelatin-based surgical sealant for prevention of postoperative adhesion", ACTA BIOMATERIALIA, vol. 121, 2021, pages 328 - 338, XP086472127, DOI: 10.1016/j.actbio.2020.12.025
TAGUCHI, TETSUSHI: "Development of surgical adhesives with anti-adhesion function after curing", UEHARA MEMORIAL FOUNDATION RESEARCH REPORTS, UEHARA MEMORIAL LIFE SCIENCE FOUNDATION, JP, vol. 35, 30 November 2020 (2020-11-30), JP , pages 1 - 5, XP009549383, ISSN: 2433-3441
ITO, SHIMA ET AL.: "Prevention of Postoperative Adhesion with a Colloidal Gel Based on Decyl Group Modified Alaska Pollock Gelatin Microparticles", ACTA BIOMATERIALIA, vol. 149, 11 June 2022 (2022-06-11), pages 139 - 149, XP087148834, DOI: 10.1016/j.actbio.2022.06.014
NISHIGUCHI, AKIHIRO ET AL.: "Underwater-adhesive microparticle dressing composed of hydrophobically-modified Alaska pollock gelatin for gastrointestinal tract wound healing", ACTA BIOMATERIALIA, vol. 99, 2019, pages 387 - 396, XP085897096, DOI: 10.1016/j.actbio.2019.08.040
NISHIGUCHI AKIHIRO, KURIHARA YUKARI, TAGUCHI TETSUSHI: "Hemostatic, Tissue-Adhesive Colloidal Wound Dressing Functionalized by UV Irradiation", ACS APPLIED BIO MATERIALS, AMERICAN CHEMICAL SOCIETY, US, vol. 3, no. 3, 16 March 2020 (2020-03-16), US , pages 1705 - 1711, XP093094854, ISSN: 2576-6422, DOI: 10.1021/acsabm.0c00015
MIZUTA, RYO ET AL.: "Evaluation of an octyl group-modified Alaska pollock gelatin-based surgical sealant for prevention of postoperative adhesion", ACTA BIOMATERIALIA, vol. 121, 2021, pages 328 - 338, XP086472127, DOI: 10.1016/j.actbio.2020.12.025
TAGUCHI, TETSUSHI: "Development of surgical adhesives with anti-adhesion function after curing", UEHARA MEMORIAL FOUNDATION RESEARCH REPORTS, UEHARA MEMORIAL LIFE SCIENCE FOUNDATION, JP, vol. 35, 30 November 2020 (2020-11-30), JP , pages 1 - 5, XP009549383, ISSN: 2433-3441
ITO, SHIMA ET AL.: "Prevention of Postoperative Adhesion with a Colloidal Gel Based on Decyl Group Modified Alaska Pollock Gelatin Microparticles", ACTA BIOMATERIALIA, vol. 149, 11 June 2022 (2022-06-11), pages 139 - 149, XP087148834, DOI: 10.1016/j.actbio.2022.06.014
Attorney, Agent or Firm:
SPRING IP (JP)
Download PDF: