Title:
ANTI-ANGIOGENIC AND CYTOTOXIC FUSED PYRIMIDINES
Document Type and Number:
WIPO Patent Application WO2003032911
Kind Code:
A3
Abstract:
This invention discloses pyrimidine compounds, and pharmaceutically acceptable salts, solvates and prodrugs thereof, useful in therapeutically and/or prophylactically treating patients with cancer by inhibiting receptor tyrosine kinases and/or dihydrofolate reductase and/or thymidylate synthase. The compounds, and methods of using these compounds, are disclosed.
Inventors:
GANGJEE ALEEM
Application Number:
PCT/US2002/032963
Publication Date:
July 31, 2003
Filing Date:
October 16, 2002
Export Citation:
Assignee:
UNIV HOLY GHOST DUQUESNE (US)
International Classes:
A61P31/10; A61P33/02; A61P33/08; A61P35/00; A61P35/04; C07D487/04; C07D491/04; C07D491/048; (IPC1-7): C07D487/04; C07D491/048; A61K31/519; A61P33/08; A61P35/00; A61P33/02; A61P31/10
Foreign References:
| US6187177B1 | 2001-02-13 | |||
| US5502187A | 1996-03-26 | |||
| US5877178A | 1999-03-02 |
Other References:
GANGJEE ALEEM ET AL.: "Synthesis of N-(4-(1-ethyl-2-(2,4-diaminofuro(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)-L-gulutamicAcidas an Antifolate", J. MED. CHEM., vol. 45, no. 9, April 2002 (2002-04-01), pages 1942 - 1948, XP002964072
GANGJEE ALEEM ET AL.: "Effect of C9-methyl substitution and C8-C9 conformational restriction on antifolate and antitumor activity of classical 5-substituted 2,4-d-diaminofuro(2,3-d)pyrimidines", J. MED. CHEM., vol. 43, no. 16, August 2000 (2000-08-01), pages 3125 - 3133, XP002964073
GANGJEE ALEEM ET AL.: "Effect of C9-methyl substitution and C8-C9 conformational restriction on antifolate and antitumor activity of classical 5-substituted 2,4-d-diaminofuro(2,3-d)pyrimidines", J. MED. CHEM., vol. 43, no. 16, August 2000 (2000-08-01), pages 3125 - 3133, XP002964073
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