Title:
ANTI-FXI/FXIA ANTIBODY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/211674
Kind Code:
A1
Abstract:
The present invention relates to the field of therapeutic monoclonal antibodies, and specifically provides an anti-FXI/FXIa antibody or an antigen-binding fragment thereof, nucleic acid molecules encoding same, and methods for preparing same. The anti-FXI/FXIa antibody or antigen-binding fragment thereof described in the present invention has specificity and high affinity to FXI/FXIa, and can effectively inhibit the activity of FXI/FXIa. Therefore, the present invention further provides a pharmaceutical composition comprising the antibody or antigen-binding fragment thereof, and a use thereof in the preparation of a drug which is used for the prevention and/or treatment of diseases or disorders related to coagulation or thromboembolism.
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Inventors:
TIAN HAIJUN (US)
LIU DENGNIAN (CN)
DENG SUJUN (US)
CIUCCI MARC PETER (US)
WANG CHENG (CN)
ZHENG YONG (CN)
XIAO LIANG (CN)
XUE TONGTONG (CN)
WANG JINGYI (CN)
LIU DENGNIAN (CN)
DENG SUJUN (US)
CIUCCI MARC PETER (US)
WANG CHENG (CN)
ZHENG YONG (CN)
XIAO LIANG (CN)
XUE TONGTONG (CN)
WANG JINGYI (CN)
Application Number:
PCT/CN2020/083413
Publication Date:
October 22, 2020
Filing Date:
April 06, 2020
Export Citation:
Assignee:
SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD (CN)
KLUS PHARMA INC (US)
KLUS PHARMA INC (US)
International Classes:
C07K16/36; A61K39/395; A61P7/02; C12N15/11
Domestic Patent References:
| WO2016207858A1 | 2016-12-29 | |||
| WO2018116255A1 | 2018-06-28 | |||
| WO2015141862A1 | 2015-09-24 | |||
| WO2002043478A2 | 2002-06-06 | |||
| WO2013167669A1 | 2013-11-14 |
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| US3996345A | 1976-12-07 | |||
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| US4366241A | 1982-12-28 | |||
| CN104341529A | 2015-02-11 | |||
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| US5530101A | 1996-06-25 | |||
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| US5693762A | 1997-12-02 | |||
| US6180370B1 | 2001-01-30 | |||
| US8388959B2 | 2013-03-05 |
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HU ET AL., CANCER RES, vol. 56, 1996, pages 3055 - 3061
KIPRIYANOV ET AL., J. MOL. BIOL., vol. 293, 1999, pages 41 - 56
ROOVERS ET AL., CANCER IMMUNOL, 2001
KOHLER ET AL., NATURE, vol. 256, 1975, pages 495
HOOGENBOOM ET AL., J. MOL. BIOL., vol. 227, 1991, pages 381 - 597
VAUGHAN ET AL., NATURE BIOTECH, vol. 14, 1996, pages 309 - 103
KOZBOR, J. IMMUNOL., vol. 133, 1984, pages 3001
BRODEUR ET AL.: "Monoclonal Antibody Production Techniques and Applications", 1987, MARCEL DEKKER, INC., pages: 51 - 63
MUNSON ET AL., ANAL. BIOCHEM., vol. 107, 1980, pages 220
D. WILKINSON: "The Scientist", vol. 14, 17 April 2000, THE SCIENTIST, INC., pages: 25 - 28
PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 6851 - 6855
JONES ET AL., NATURE, vol. 321, 1986, pages 522 - 596
REICHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 329
PRESTA, CURR. OP. STRUCT. BIOL., vol. 2, 1992, pages 593 - 596
KABAT, EA ET AL.: "Sequences of Proteins of Immunological Interest, Fifth Edition", 1991, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
"Antibody Engineering: Methods and Protocols", vol. 248, 2004, HUMANA PRESS
JAKOBOVITS ET AL., NATURE, vol. 361, 1993, pages 186 - 187
BRUGGERMANN ET AL., YEAR IN IMMUNOLOGY, vol. 7, 1993, pages 33
DUCHOSAL ET AL., NATURE, vol. 355, 1992, pages 258
LONBERG ET AL., NATURE, vol. 368, no. 6474, 1994, pages 856 - 859
SMITH TFWATERMAN MS, ADV.APPL.MATH., vol. 2, 1981, pages 482
ALTSCHUL SF ET AL., NATURE GENET., vol. 6, 1994, pages 119
DAVIES ET AL., ANNUAL REV BIOCHEM, vol. 59, 1990, pages 439 - 473
NEEDLEMAN ET AL., J. MOL. BIOL., vol. 48, 1970, pages 444 - 453
E. MEYERSW. MILLER, COMPUT. APPL. BIOSCI., vol. 4, 1988, pages 11 - 17
BRUMMELL ET AL., BIOCHEM, vol. 32, 1993, pages 1180 - 1187
KOBAYASHI ET AL., PROTEIN ENG, vol. 12, no. 10, 1999, pages 879 - 884
BURKS ET AL., PROC. NATL ACAD. SET USA, vol. 94, 1997, pages 412 - 417
F.M. AUSUBEL ET AL.: "Short Protocols in Molecular Biology", 1995, MACK PUBLISHING COMPANY
J. SAMBROOK ET AL.: "Molecular Cloning: Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
EUR. J. BIOCHEM., vol. 172, 1988, pages 17 - 25
J MED CHEM., vol. 60, no. 23, 17 November 2017 (2017-11-17), pages 9703 - 9723
See also references of EP 3957652A4
MORIMOTO ET AL., J. BIOCHEM. BIOPHYS. METHODS, vol. 24, 1992, pages 107 - 117
BRENNAN ET AL., SCIENCE, vol. 229, 1985, pages 81
HUDSON, CURR. OPIN. IMMUNOL., vol. 11, 1999, pages 548 - 557
LITTLE ET AL., IMMUNOL. TODAY, vol. 21, 2000, pages 397 - 402
CARTER ET AL., BIO/TECHNOLOGY, vol. 10, 1992, pages 163 - 167
CLACKSON ET AL., NATURE, vol. 352, 1991, pages 624 - 628
CHOTHIALESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
CHOTHIA ET AL., NATURE, vol. 341, 1989, pages 544 - 546
MARTIN ACR, CHEETHAM JC,REES AR: "Modelling antibody hypervariable loops: A combined algorithm", PROC NATL ACAD SCI USA, vol. 86, 1989, pages 9268 - 9272, XP000165667, DOI: 10.1073/pnas.86.23.9268
LEFRANC ET AL., DEV. COMPARAT. IMMUNOL., vol. 27, 2003, pages 55 - 77
MARTIN ACRCHEETHAM JCREES AR, PROC NATL ACAD SCI USA, vol. 86, 1989, pages 9268 - 9272
HIGGINS DGSHARP PM, CABIOS, vol. 5, 1989, pages 151
HOLLIGER ET AL., NAT BIOTECHNOL, vol. 23, 2005, pages 1126 - 1136
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883
POLJAK RJ ET AL., STRUCTURE, vol. 113, 1994, pages 1121 - 1123
JAKOBOVITS ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 2551 - 6448
ALFTHAN ET AL., PROTEIN ENG, vol. 8, 1995, pages 725 - 731
CHOI ET AL., EUR. J. IMMUNOL., vol. 31, 2001, pages 94 - 106
HU ET AL., CANCER RES, vol. 56, 1996, pages 3055 - 3061
KIPRIYANOV ET AL., J. MOL. BIOL., vol. 293, 1999, pages 41 - 56
ROOVERS ET AL., CANCER IMMUNOL, 2001
KOHLER ET AL., NATURE, vol. 256, 1975, pages 495
HOOGENBOOM ET AL., J. MOL. BIOL., vol. 227, 1991, pages 381 - 597
VAUGHAN ET AL., NATURE BIOTECH, vol. 14, 1996, pages 309 - 103
KOZBOR, J. IMMUNOL., vol. 133, 1984, pages 3001
BRODEUR ET AL.: "Monoclonal Antibody Production Techniques and Applications", 1987, MARCEL DEKKER, INC., pages: 51 - 63
MUNSON ET AL., ANAL. BIOCHEM., vol. 107, 1980, pages 220
D. WILKINSON: "The Scientist", vol. 14, 17 April 2000, THE SCIENTIST, INC., pages: 25 - 28
PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 6851 - 6855
JONES ET AL., NATURE, vol. 321, 1986, pages 522 - 596
REICHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 329
PRESTA, CURR. OP. STRUCT. BIOL., vol. 2, 1992, pages 593 - 596
KABAT, EA ET AL.: "Sequences of Proteins of Immunological Interest, Fifth Edition", 1991, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
"Antibody Engineering: Methods and Protocols", vol. 248, 2004, HUMANA PRESS
JAKOBOVITS ET AL., NATURE, vol. 361, 1993, pages 186 - 187
BRUGGERMANN ET AL., YEAR IN IMMUNOLOGY, vol. 7, 1993, pages 33
DUCHOSAL ET AL., NATURE, vol. 355, 1992, pages 258
LONBERG ET AL., NATURE, vol. 368, no. 6474, 1994, pages 856 - 859
SMITH TFWATERMAN MS, ADV.APPL.MATH., vol. 2, 1981, pages 482
ALTSCHUL SF ET AL., NATURE GENET., vol. 6, 1994, pages 119
DAVIES ET AL., ANNUAL REV BIOCHEM, vol. 59, 1990, pages 439 - 473
NEEDLEMAN ET AL., J. MOL. BIOL., vol. 48, 1970, pages 444 - 453
E. MEYERSW. MILLER, COMPUT. APPL. BIOSCI., vol. 4, 1988, pages 11 - 17
BRUMMELL ET AL., BIOCHEM, vol. 32, 1993, pages 1180 - 1187
KOBAYASHI ET AL., PROTEIN ENG, vol. 12, no. 10, 1999, pages 879 - 884
BURKS ET AL., PROC. NATL ACAD. SET USA, vol. 94, 1997, pages 412 - 417
F.M. AUSUBEL ET AL.: "Short Protocols in Molecular Biology", 1995, MACK PUBLISHING COMPANY
J. SAMBROOK ET AL.: "Molecular Cloning: Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
EUR. J. BIOCHEM., vol. 172, 1988, pages 17 - 25
J MED CHEM., vol. 60, no. 23, 17 November 2017 (2017-11-17), pages 9703 - 9723
See also references of EP 3957652A4
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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