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Title:
ANTI-B7H3 CHIMERIC ANTIGEN RECEPTOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/126689
Kind Code:
A1
Abstract:
Provided are an anti-B7H3 chimeric antigen receptor and an application thereof. The anti-B7H3 chimeric antigen receptor comprises an antigen binding domain, a hinge region, a transmembrane domain and a signaling transfer structural domain. The antigen binding domain is an anti-human B7H3 antibody. The anti-B7H3 chimeric antigen receptor has a specific targeting effect on B7H3-positive tumor cells, T cells that express the anti-B7H3 chimeric antigen receptor have significant killing effects in vitro and in vivo, can effectively remove the B7H3-positive tumor cells, and having important significance in the field of tumor therapy.

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Inventors:
LI GUANGCHAO (CN)
LUO MIN (CN)
DING WEN (CN)
ZHOU ZHAO (CN)
WANG XUEJUN (CN)
Application Number:
PCT/CN2020/138243
Publication Date:
June 23, 2022
Filing Date:
December 22, 2020
Export Citation:
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Assignee:
GUANGZHOU BIO GENE TECH CO LTD (CN)
International Classes:
C07K19/00; A61K39/00; A61P35/00; A61P35/02; C12N5/0783; C12N5/10; C12N15/62; C12N15/867
Domestic Patent References:
WO2016044383A12016-03-24
Foreign References:
CN109912718A2019-06-21
CN109609533A2019-04-12
CN110684790A2020-01-14
CN109929039A2019-06-25
CN111662384A2020-09-15
CN109880804A2019-06-14
CN111386347A2020-07-07
CN110950953A2020-04-03
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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