Title:
ANTI-PD1×PDL1 BISPECIFIC ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2021/244392
Kind Code:
A1
Abstract:
Provided are an anti-PD1×PDL1 bispecific antibody, a preparation method therefor and use thereof. The experimental results show that the bispecific antibody can well maintain the activity of each monoclonal antibody, and can specifically bind to two target points, i.e. PD-1 and PD-L1, at the same time, and has good physicochemical properties.
Inventors:
ZHU ZHENPING (CN)
HUANG HAOMIN (CN)
GU CHANGLING (CN)
ZHU HAIXIA (CN)
HUANG HAOMIN (CN)
GU CHANGLING (CN)
ZHU HAIXIA (CN)
Application Number:
PCT/CN2021/096396
Publication Date:
December 09, 2021
Filing Date:
May 27, 2021
Export Citation:
Assignee:
SUNSHINE GUOJIAN PHARMACEUTICAL SHANGHAI CO LTD (CN)
International Classes:
A61K39/395; C07K16/46; A61P35/00; C07K16/28
Domestic Patent References:
| WO2019148412A1 | 2019-08-08 | |||
| WO2020102387A1 | 2020-05-22 |
Foreign References:
| CN109310755A | 2019-02-05 | |||
| CN111196855A | 2020-05-26 | |||
| CN110914306A | 2020-03-24 |
Other References:
EVA DAHLEN, NIINA VEITONMÄKI, PER NORLEN: "Bispecific antibodies in cancer immunotherapy", THERAPEUTIC ADVANCES IN VACCINES AND IMMUNOTHERAPY, vol. 6, no. 1, 1 January 2018 (2018-01-01), pages 3 - 17, XP055724834, DOI: 10.1177/2515135518763280Therapeutic
VITALE LAURA A.; HE LI-ZHEN; THOMAS LAWRENCE J.; WASIUK ANNA; O’NEILL THOMAS; WIDGER JENIFER; CROCKER ANDREA; MILLS-CHEN LAU: "Development of CDX-527: a bispecific antibody combining PD-1 blockade and CD27 costimulation for cancer immunotherapy", CANCER IMMUNOLOGY IMMUNOTHERAPY, SPRINGER, BERLIN/HEIDELBERG, vol. 69, no. 10, 25 May 2020 (2020-05-25), Berlin/Heidelberg , pages 2125 - 2137, XP037253276, ISSN: 0340-7004, DOI: 10.1007/s00262-020-02610-y
VITALE LAURA A.; HE LI-ZHEN; THOMAS LAWRENCE J.; WASIUK ANNA; O’NEILL THOMAS; WIDGER JENIFER; CROCKER ANDREA; MILLS-CHEN LAU: "Development of CDX-527: a bispecific antibody combining PD-1 blockade and CD27 costimulation for cancer immunotherapy", CANCER IMMUNOLOGY IMMUNOTHERAPY, SPRINGER, BERLIN/HEIDELBERG, vol. 69, no. 10, 25 May 2020 (2020-05-25), Berlin/Heidelberg , pages 2125 - 2137, XP037253276, ISSN: 0340-7004, DOI: 10.1007/s00262-020-02610-y
Attorney, Agent or Firm:
J.Z.M.C. PATENT AND TRADEMARK LAW OFFICE (CN)
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