Title:
ANTI-C-MET ANTIBODY-DRUG CONJUGATE AND APPLICATIONS THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/048521
Kind Code:
A1
Abstract:
Related to the technical field of c-Met antibody drugs, specifically related are a c-Met-targeted antibody-drug conjugate and applications thereof. The antibody-drug conjugate comprises an antibody conjugated with one or more therapeutic agents or antigen-binding fragments of the antibody; the conjugate effectively inhibits the growth of a tumor tissue, provides a significant inhibitory effect with respect to c-Met-positive cancer, and has excellent safety.
Inventors:
FANG JIANMIN (CN)
HUANG CHANGJIANG (CN)
YAO XUEJING (CN)
LUO WENTING (CN)
HUANG CHANGJIANG (CN)
YAO XUEJING (CN)
LUO WENTING (CN)
Application Number:
PCT/CN2021/115490
Publication Date:
March 10, 2022
Filing Date:
August 31, 2021
Export Citation:
Assignee:
REMEGEN CO LTD (CN)
International Classes:
A61K39/395; A61K47/68; A61P35/00; C07K16/28
Domestic Patent References:
| WO2019175186A1 | 2019-09-19 | |||
| WO2019223579A1 | 2019-11-28 | |||
| WO2020108612A1 | 2020-06-04 | |||
| WO2020101365A1 | 2020-05-22 | |||
| WO2011020925A1 | 2011-02-24 | |||
| WO2019223579A1 | 2019-11-28 |
Foreign References:
| CN109771642A | 2019-05-21 | |||
| CN109541221A | 2019-03-29 | |||
| CN108853514A | 2018-11-23 | |||
| CN111433188A | 2020-07-17 | |||
| CN104628867A | 2015-05-20 | |||
| CN108853514A | 2018-11-23 | |||
| CN111433188A | 2020-07-17 |
Other References:
GUO JIA, JIANG YUN;TENG FEI;YIN YANXIN;YU LIHUA;FU MIN;JIANG MING;FANG JIANMIN: "Construction of Chimeric Anti-c-Met Antibody Random Mutagenesis Libraries Using Mammalian Cell Surface Display", CHINESE JOURNAL OF CELLULAR AND MOLECULAR IMMUNOLOGY, vol. 35, no. 6, 31 December 2019 (2019-12-31), pages 557 - 562, XP055907620, DOI: 10.13423/j.cnki.cjcmi.008830
GUO, JIA; JIANG, MING; JIN, LINGJING; YIN, YANXIN; SUN, HUI: "Preparation and Biological Activity of Anti-human C-mesenchymal Epithelial Transition Factor(c-Met) Monovalent Antibody", CHINESE JOURNAL OF CELLULAR AND MOLECULAR IMMUNOLOGY, vol. 32, no. 11, 31 December 2016 (2016-12-31), CN , pages 1544 - 1548, 1553, XP009534938, ISSN: 1007-8738, DOI: 10.13423/j.cnki.cjcmi.007960
ZHANG LONGZHEN, GUO JIA;GU HUA;FANG JIANMIN: "Construction of Chimeric Anti-c-Met Antibody and Its Rapid Expression Using Lentiviral Vector", HE FEI GONG YE DA XUE XUE BAO = JOURNAL OF HEFEI UNIVERSITY OF TECHNOLOGY // ZI RAN KE XUE BAN = NATURAL SCIENCE EDITION, HE FEI GONG YE DA XUE XUE BAO ZA ZHI SHE, CN, vol. 40, no. 6, 30 June 2017 (2017-06-30), CN , pages 835 - 839, XP055907628, ISSN: 1003-5060, DOI: 10.3969/j.issn.1003-5060.2017.06.022
YIN YANXIN, GUO JIA, TENG FEI, YU LIHUA, JIANG YUN, XIE KUN, JIANG MING, FANG JIANMIN: "Preparation of a Novel One-Armed Anti-c-Met Antibody with Antitumor Activity Against Hepatocellular Carcinoma", DRUG DESIGN, DEVELOPMENT AND THERAPY, vol. Volume 13, 10 December 2019 (2019-12-10), pages 4173 - 4184, XP055907632, DOI: 10.2147/DDDT.S224491
HUANG LEI, XIE KUN, LI HONGWEN, WANG RUIQIN, XU XIAOQING, CHEN KAIMING, GU HUA, FANG JIANMIN: "Suppression of c-Met-Overexpressing Tumors by a Novel c-Met/CD3 Bispecific Antibody", DRUG DESIGN, DEVELOPMENT AND THERAPY, vol. Volume 14, 7 August 2020 (2020-08-07), pages 3201 - 3214, XP055907634, DOI: 10.2147/DDDT.S254117
EDAKUNI GSASATOMI ESATOH T ET AL.: "Expression of the hepatocyte growth factor/c-Met pathway is increased at the cancer front in breast carcinoma", PATHOLOGY INTERNATIONAL, vol. 51, no. 3, 2010, pages 172 - 178
SATTLER MREDDY M MHASINA R ET AL.: "The role of the c-Met pathway in lung cancer and the potential for targeted therapy", THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, vol. 3, no. 4, 2011, pages 171 - 84, XP008158366, DOI: 10.1177/1758834011408636
PERUZZI BBOTTARO D P: "Targeting the c-Met Signaling Pathway in Cancer", CLINICAL CANCER RESEARCH, vol. 12, no. 12, 2006, pages 3657 - 3660, XP002588638
WANG JANDERSON M GOLEKSIJEW A ET AL.: "ABBV-399, a c-Met Antibody-drug conjugate that Targets Both MET Amplified and c-Met Overexpressing Tumors, Irrespective of MET Pathway Dependence", CLINICAL CANCER RESEARCH, vol. 23, no. 4, 2016, pages 992 - 1000, XP055394339, DOI: 10.1158/1078-0432.CCR-16-1568
ANGEVIN EKELLY KHEIST R ET AL.: "First-in-human phase 1, dose-escalation and -expansion study of ABBV-399, an antibody-drug conjugate (ADC) targeting c-Met, in patients (pts) with advanced solid tumors", ANNALS OF ONCOLOGY, vol. 27, 2016
KABAT ET AL.: "Sequences of proteins of immunological interest", 1991, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
SMITHWATERMAN, AD. APP. MATH., vol. 2, 1981, pages 482
NEDDLEMANWUNSCH, J. MOL. BIOL., vol. 48, 1970, pages 443
PEARSONLIPMAN, PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 2444
JONES ET AL., NATURE, vol. 321, 1986, pages 522 - 525
VERHOEYEN ET AL., SCIENCE, vol. 239, 1988, pages 1534 - 1536
RIECHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 327
VERHOEYN ET AL., BIOESSAYS, vol. 8, 1988, pages 74
HARLOWLANE: "Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY, pages: 726
KOHLERMILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
See also references of EP 4129335A4
GUO, JIA; JIANG, MING; JIN, LINGJING; YIN, YANXIN; SUN, HUI: "Preparation and Biological Activity of Anti-human C-mesenchymal Epithelial Transition Factor(c-Met) Monovalent Antibody", CHINESE JOURNAL OF CELLULAR AND MOLECULAR IMMUNOLOGY, vol. 32, no. 11, 31 December 2016 (2016-12-31), CN , pages 1544 - 1548, 1553, XP009534938, ISSN: 1007-8738, DOI: 10.13423/j.cnki.cjcmi.007960
ZHANG LONGZHEN, GUO JIA;GU HUA;FANG JIANMIN: "Construction of Chimeric Anti-c-Met Antibody and Its Rapid Expression Using Lentiviral Vector", HE FEI GONG YE DA XUE XUE BAO = JOURNAL OF HEFEI UNIVERSITY OF TECHNOLOGY // ZI RAN KE XUE BAN = NATURAL SCIENCE EDITION, HE FEI GONG YE DA XUE XUE BAO ZA ZHI SHE, CN, vol. 40, no. 6, 30 June 2017 (2017-06-30), CN , pages 835 - 839, XP055907628, ISSN: 1003-5060, DOI: 10.3969/j.issn.1003-5060.2017.06.022
YIN YANXIN, GUO JIA, TENG FEI, YU LIHUA, JIANG YUN, XIE KUN, JIANG MING, FANG JIANMIN: "Preparation of a Novel One-Armed Anti-c-Met Antibody with Antitumor Activity Against Hepatocellular Carcinoma", DRUG DESIGN, DEVELOPMENT AND THERAPY, vol. Volume 13, 10 December 2019 (2019-12-10), pages 4173 - 4184, XP055907632, DOI: 10.2147/DDDT.S224491
HUANG LEI, XIE KUN, LI HONGWEN, WANG RUIQIN, XU XIAOQING, CHEN KAIMING, GU HUA, FANG JIANMIN: "Suppression of c-Met-Overexpressing Tumors by a Novel c-Met/CD3 Bispecific Antibody", DRUG DESIGN, DEVELOPMENT AND THERAPY, vol. Volume 14, 7 August 2020 (2020-08-07), pages 3201 - 3214, XP055907634, DOI: 10.2147/DDDT.S254117
EDAKUNI GSASATOMI ESATOH T ET AL.: "Expression of the hepatocyte growth factor/c-Met pathway is increased at the cancer front in breast carcinoma", PATHOLOGY INTERNATIONAL, vol. 51, no. 3, 2010, pages 172 - 178
SATTLER MREDDY M MHASINA R ET AL.: "The role of the c-Met pathway in lung cancer and the potential for targeted therapy", THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, vol. 3, no. 4, 2011, pages 171 - 84, XP008158366, DOI: 10.1177/1758834011408636
PERUZZI BBOTTARO D P: "Targeting the c-Met Signaling Pathway in Cancer", CLINICAL CANCER RESEARCH, vol. 12, no. 12, 2006, pages 3657 - 3660, XP002588638
WANG JANDERSON M GOLEKSIJEW A ET AL.: "ABBV-399, a c-Met Antibody-drug conjugate that Targets Both MET Amplified and c-Met Overexpressing Tumors, Irrespective of MET Pathway Dependence", CLINICAL CANCER RESEARCH, vol. 23, no. 4, 2016, pages 992 - 1000, XP055394339, DOI: 10.1158/1078-0432.CCR-16-1568
ANGEVIN EKELLY KHEIST R ET AL.: "First-in-human phase 1, dose-escalation and -expansion study of ABBV-399, an antibody-drug conjugate (ADC) targeting c-Met, in patients (pts) with advanced solid tumors", ANNALS OF ONCOLOGY, vol. 27, 2016
KABAT ET AL.: "Sequences of proteins of immunological interest", 1991, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
SMITHWATERMAN, AD. APP. MATH., vol. 2, 1981, pages 482
NEDDLEMANWUNSCH, J. MOL. BIOL., vol. 48, 1970, pages 443
PEARSONLIPMAN, PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 2444
JONES ET AL., NATURE, vol. 321, 1986, pages 522 - 525
VERHOEYEN ET AL., SCIENCE, vol. 239, 1988, pages 1534 - 1536
RIECHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 327
VERHOEYN ET AL., BIOESSAYS, vol. 8, 1988, pages 74
HARLOWLANE: "Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY, pages: 726
KOHLERMILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
See also references of EP 4129335A4
Download PDF:
Previous Patent: AIR HANDLING DEVICE AND VEHICLE AIR CONDITIONER MODULE
Next Patent: TOP CONNECTING PIECE FOR TAPERED TENT
Next Patent: TOP CONNECTING PIECE FOR TAPERED TENT