ANTI-C5 ANTIBODIES AND METHODS OF USE

WIPO Patent Application WO/2017/217524

A1

The invention provides anti-C5 antibodies and methods of using the same. In some embodiments, an isolated anti-C5 antibody of the present invention binds to an epitope within the beta chain of C5 with a higher affinity at neutral pH than at acidic pH. The invention also provides isolated nucleic acids encoding an anti-C5 antibody of the present invention. The invention also provides host cells comprising a nucleic acid of the present invention. The invention also provides a method of producing an antibody comprising culturing a host cell of the present invention so that the antibody is produced. The invention further provides a method of producing an anti-C5 antibody comprising immunizing an animal against a polypeptide which comprises the MG1-MG2 domain of the beta chain of C5. Anti-C5 antibodies of the present invention may be for use as a medicament.

JP2003259870	NOVEL POLYNUCLEOTIDE AND POLYPEPTIDE
JP2002191372	NEW NUCLEIC ACID PROBE, METHOD FOR ASSAYING NUCLEIC ACID AND METHOD FOR ANALYZING DATA OBTAINED BY THE METHOD

RUIKE YOSHINAO (SG)
SAMPEI ZENJIRO (SG)

PCT/JP2017/022253

December 21, 2017

June 16, 2017

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CHUGAI PHARMACEUTICAL CO LTD (JP)

C12N15/09; A61K39/395; A61P7/00; C07K16/18

WO2016098356A1	2016-06-23
WO2010015608A1	2010-02-11
WO1995029697A1	1995-11-09
WO2014160958A1	2014-10-02
WO2015134894A1	2015-09-11
WO2011111007A2	2011-09-15

US20160068592A1	2016-03-10
US20110111406A1	2011-05-12

FUKUZAWA T ET AL.: "Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases", SCI. REP., vol. 7, no. 1, 24 April 2017 (2017-04-24), pages 1080, XP055399003, Retrieved from the Internet [retrieved on 20170705]
See also references of EP 3472316A4

HARUNA, Masao et al. (JP)

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