Title:
ANTI-CANCER AGENT
Document Type and Number:
WIPO Patent Application WO/2008/044704
Kind Code:
A1
Abstract:
Disclosed is a novel anti-cancer agent which is less likely to be excreted from a cancer cell and is suitable for the local treatment against a cancer cell. The anti-cancer agent comprises a rotaxane compound represented by the chemical formula (I) as an active ingredient. The rotaxane compound is composed of two moieties; namely, a rod-like moiety having a relatively large molecule attached to each of both ends, and a cyclic moiety (a crown ether) into which the rod-like moiety is inserted. The cyclic moiety cannot be detached from the rod-like moiety, because the rod-like moiety has a relatively large molecule attached to each of both ends and the relatively large molecule serves as a stopper for the detachment. The bond between the two moieties is not a covalent bond. Therefore, the shape of the molecule can be varied readily, and the uptake of the molecule via a receptor becomes relatively difficult. However, once the molecule is introduced into a cancer cell, the proliferation of the cancer cell can be inhibited.
More Like This:
Inventors:
ONO NOBUFUMI (JP)
Application Number:
PCT/JP2007/069747
Publication Date:
April 17, 2008
Filing Date:
October 10, 2007
Export Citation:
Assignee:
WAN STATION CO LTD (JP)
ONO NOBUFUMI (JP)
ONO NOBUFUMI (JP)
International Classes:
A61P35/00; A61K31/357; C07D323/00
Foreign References:
| JP2005247790A | 2005-09-15 | |||
| JP3741706B2 | 2006-02-01 |
Other References:
KIHARA N. ET AL.: "Direct preparation of rotaxane from aminoalcohol: selective O-acylation of aminoalcohol in the presence of trifluoromethanesulfonic acid and crown ether", CHEMISTRY LETTERS, vol. 30, no. 6, 2001, pages 592 - 593, XP003022166
TEODORI E. ET AL.: "Exploratory Chemistry toward the Identification of a New Class of Multidrug REsistance Reverters Inspired by Pervilleine and Verapamil Models", JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, no. 23, 2005, pages 7426 - 7436, XP003022167
TOSHIKAZU TAKATA; NOBUHIRO KIHARA; YOSHIO FURUSHO: "Functionality design of nano materials by synthesis of interlocked compounds", KOBUNSHI, vol. 50, no. 11, 2001, pages 770 - 773
YOSHIO FURUSHO; NOBUHIRO KIHARA; TOSHIKAZU TAKATA: "Synthesis of rotaxane and polyrotaxane exploiting slipping reaction: New synthetic methodof polymeric materials", POLYM.APPL., vol. 50, no. 3, 2001, pages 114 - 120
NOBUHIRO KIHARA; TOSHIKAZU TAKATA: "Efficient syntheses of interlocked molecules based on hydrogen-bonding: Recent progress in syntheses of rotaxanes and catenanes", YUKI GOSEI KAGAKU KYOKAISHI, vol. 59, no. 3, 2001, pages 206 - 218
TEODORI E. ET AL.: "Exploratory Chemistry toward the Identification of a New Class of Multidrug REsistance Reverters Inspired by Pervilleine and Verapamil Models", JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, no. 23, 2005, pages 7426 - 7436, XP003022167
TOSHIKAZU TAKATA; NOBUHIRO KIHARA; YOSHIO FURUSHO: "Functionality design of nano materials by synthesis of interlocked compounds", KOBUNSHI, vol. 50, no. 11, 2001, pages 770 - 773
YOSHIO FURUSHO; NOBUHIRO KIHARA; TOSHIKAZU TAKATA: "Synthesis of rotaxane and polyrotaxane exploiting slipping reaction: New synthetic methodof polymeric materials", POLYM.APPL., vol. 50, no. 3, 2001, pages 114 - 120
NOBUHIRO KIHARA; TOSHIKAZU TAKATA: "Efficient syntheses of interlocked molecules based on hydrogen-bonding: Recent progress in syntheses of rotaxanes and catenanes", YUKI GOSEI KAGAKU KYOKAISHI, vol. 59, no. 3, 2001, pages 206 - 218
Attorney, Agent or Firm:
KURODA, Hiromichi et al. (3-6 Kudanminami 3-chome,Chiyoda-k, Tokyo 74, JP)
Download PDF:
Previous Patent: STATOR OF ROTATING ELECTRIC MACHINE
Next Patent: ARTIFICIAL TOOTH-TYPE IONTOPHORESIS DEVICE
Next Patent: ARTIFICIAL TOOTH-TYPE IONTOPHORESIS DEVICE