Title:
ANTI-ERYTHROPOIETIN RECEPTOR PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2020/054813
Kind Code:
A1
Abstract:
The present invention provides an anti-EpoR peptide having the structure represented by formula (I): X1-SCH(A1)(A2)(A3)(A4)(A5)(A6)V(A7)(A8)-X2 (X1 is the amino terminal side of the peptide; X2 is the carboxy terminal side of the peptide; A1 is M or F, phenylglycine or phenethylglycine optionally substituted by a halogen atom or a hydroxyl group; A2 is A, d-alanine or G; A3 is P, homoproline or A; A4 is M, L, A or I; A5 is T or A; A6 is M or W, F, Y, β-homotryptophan, α-naphthylalanine, β-naphthylalanine, or quinolylalanine optionally substituted by methyl or a halogen atom; A7 is C, homocysteine, or penicillamine; and A8 is K, R or does not exist.).
Inventors:
KOUJI HIROYUKI (JP)
YASUDA YOSHIKO (JP)
KATO AKIRA (JP)
OCHI HIROSHI (JP)
YASUDA YOSHIKO (JP)
KATO AKIRA (JP)
OCHI HIROSHI (JP)
Application Number:
PCT/JP2019/035949
Publication Date:
March 19, 2020
Filing Date:
September 12, 2019
Export Citation:
Assignee:
EPO MED INC (JP)
International Classes:
C07K7/08; A61K38/02; A61K47/54; A61P3/00; A61P15/00; A61P27/02; A61P35/00; A61P35/02
Domestic Patent References:
| WO2017014312A1 | 2017-01-26 |
Foreign References:
| JP2003201252A | 2003-07-18 | |||
| JPH11507367A | 1999-06-29 | |||
| JP2007529475A | 2007-10-25 | |||
| JP2003534384A | 2003-11-18 | |||
| JP2018172479A | 2018-11-08 |
Other References:
YOSHIKO YASUDA, MITSUGU FUJITA: "Significance of erythropoietin receptor antagonist EMP9 in cancers", VITAMINS AND HORMONES, vol. 105, 2017, pages 297 - 310, XP009527216, ISSN: 2162-2620
KRANTZ S. B., BLOOD, vol. 77, 1991, pages 419 - 434
D'ANDREA A. D. ET AL., CELL, vol. 57, 1989, pages 277 - 285
YASUDA Y. ET AL., DEVELOP. GROWTH DIFFER., vol. 35, 1993, pages 711 - 722
MARTI H. H. ET AL., EUR. J. NEUROSCI., vol. 8, 1996, pages 666 - 676
YASUDA Y. ET AL., J. BIOL. CHEM., vol. 273, 1998, pages 25381 - 25387
NOBUO IZUMIYA ET AL.: "Pepuchido Gosei no Kiso to Jikken [Fundamentals and experiments of peptide synthesis", 1985, MARUZEN
"Polymer chemistry", vol. 26, 2007, MARUZEN, article "The Fifth Series of Experimental Chemistry"
YASUYOSHI NOGAMI: "Patona Yakuhin Seizogaku [Partner Pharmaceutical Technochemistry", 2012, NANKODO
STRECKER, A: "Ueber die kunstliche Bildung der Milchsaure und einen neuen, dem Glycocoll homologen Korper", ANN, vol. 75, 8 January 1950 (1950-01-08), pages 27 - 45
STRECKER, A: "Ueber einen neuen aus Aldehyd-Ammoniak und Blausaure entstehenden Korper", ANN, vol. 91, 8 January 1954 (1954-01-08), pages 349 - 351
See also references of EP 3851448A4
KRANTZ S. B., BLOOD, vol. 77, 1991, pages 419 - 434
D'ANDREA A. D. ET AL., CELL, vol. 57, 1989, pages 277 - 285
YASUDA Y. ET AL., DEVELOP. GROWTH DIFFER., vol. 35, 1993, pages 711 - 722
MARTI H. H. ET AL., EUR. J. NEUROSCI., vol. 8, 1996, pages 666 - 676
YASUDA Y. ET AL., J. BIOL. CHEM., vol. 273, 1998, pages 25381 - 25387
NOBUO IZUMIYA ET AL.: "Pepuchido Gosei no Kiso to Jikken [Fundamentals and experiments of peptide synthesis", 1985, MARUZEN
"Polymer chemistry", vol. 26, 2007, MARUZEN, article "The Fifth Series of Experimental Chemistry"
YASUYOSHI NOGAMI: "Patona Yakuhin Seizogaku [Partner Pharmaceutical Technochemistry", 2012, NANKODO
STRECKER, A: "Ueber die kunstliche Bildung der Milchsaure und einen neuen, dem Glycocoll homologen Korper", ANN, vol. 75, 8 January 1950 (1950-01-08), pages 27 - 45
STRECKER, A: "Ueber einen neuen aus Aldehyd-Ammoniak und Blausaure entstehenden Korper", ANN, vol. 91, 8 January 1954 (1954-01-08), pages 349 - 351
See also references of EP 3851448A4
Attorney, Agent or Firm:
YAMAMOTO Shusaku et al. (JP)
Download PDF:
Previous Patent: SELECTION OF RADIO ACCESS TECHNOLOGIES FOR V2X MESSAGES
Next Patent: IMAGE HEATING DEVICE AND IMAGE FORMATION DEVICE
Next Patent: IMAGE HEATING DEVICE AND IMAGE FORMATION DEVICE