Title:
ANTI-GROWTH HORMONE ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2023/032955
Kind Code:
A1
Abstract:
In one embodiment, the present invention provides an antibody specifically binding to human GH, or an antigen-binding fragment thereof. In one embodiment, the present invention pertains to an antibody specifically binding to human GH, or an antigen-binding fragment thereof, the antibody or antigen-binding fragment thereof comprising a heavy chain variable region (VH) and a light chain variable region (VL), wherein: the VH includes the amino acid sequence of SEQ ID NO: 5 as a VH complementarity determining region (CDR) 1 (VHCDR1), the amino acid sequence of SEQ ID NO: 6 as a VHCDR2, and the amino acid sequence of SEQ ID NO: 7 as a VHCDR3; and the VL includes the amino acid sequence of SEQ ID NO: 8 as a VL complementarity determining region (CDR) 1 (VLCDR1), the amino acid sequence of SEQ ID NO: 9 as a VLCDR2, and the amino acid sequence of SEQ ID NO: 10 as a VLCDR3.
Inventors:
KUROKAWA TOMOFUMI (JP)
UEMATSU YOSHIKATSU (JP)
HATA TOMOYUKI (JP)
ADACHI HISASHI (JP)
SUGITA AYUMI (JP)
UEMATSU YOSHIKATSU (JP)
HATA TOMOYUKI (JP)
ADACHI HISASHI (JP)
SUGITA AYUMI (JP)
Application Number:
PCT/JP2022/032523
Publication Date:
March 09, 2023
Filing Date:
August 30, 2022
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
International Classes:
C12N15/13; A61K39/395; A61P3/10; A61P5/08; A61P11/00; A61P13/12; A61P19/02; A61P29/00; A61P35/00; A61P43/00; C07K16/26; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/63; C12P21/08
Domestic Patent References:
| WO1997036929A1 | 1997-10-09 |
Foreign References:
| JP2000508889A | 2000-07-18 | |||
| JPH10191974A | 1998-07-28 | |||
| US7083784B2 | 2006-08-01 | |||
| US7217797B2 | 2007-05-15 | |||
| US8088376B2 | 2012-01-03 | |||
| US5223409A | 1993-06-29 | |||
| US5885793A | 1999-03-23 | |||
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| US6881557B2 | 2005-04-19 | |||
| US5807715A | 1998-09-15 | |||
| US4816567A | 1989-03-28 | |||
| US6331415B1 | 2001-12-18 |
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CAROLINE LEGER ET AL.: "Adenovirus-mediated gene transfer of hIGF-IB in mouse lungs induced prolonged inflammation but no fibroproliferation", AM J PHYSIOL LUNG CELL MOL PHYSIOL., vol. 298, no. 4, 2010, pages 492 - 500
IVANYI J.: "Study of antigenic structure and inhibition of activity of human growth hormone and chorionic somatomammotropin by monoclonal antibodies", MOL. IMMUNOL., vol. 19, 1982, pages 1611 - 1618, XP023680901, DOI: 10.1016/0161-5890(82)90272-3
BURBRIDGE D. ET AL.: "Actions of monoclonal antibodies on the activity of human growth hormone (GH) in an in vitro bioassay", MOL. CELL. ENDOCRINOL., vol. 174, 2001, pages 11 - 19
MELLADO M. ET AL.: "Characterization of monoclonal antibodies specific for the human growth hormone 22K and 20K isoforms", J. CLIN. ENDOCRINOL. METAB., vol. 81, 1996, pages 1613 - 1618, XP000983139, DOI: 10.1210/jc.81.4.1613
ROGUIN L. P.: "Monoclonal antibodies to human growth hormone modulate its biological properties ", IMMUNOL., vol. 32, 1995, pages 399 - 405
LATTUADA D.: "Monoclonal antibodies against recombinant human growth hormone as probes to study immune function.", HYBRIDOMA, vol. 15, 1996, pages 211 - 217, XP009066561
SATO Y. ET AL.: "Characterization of monoclonal antibodies to human growth hormone (hGH", TOKYO JOSHI IKA DAIGAKU ZASSHI, vol. 54, 1984, pages 493 - 506
ISHIKAWA M. ET AL.: "Novel Specific Bioassay for Serum Human Growth Hormone", J. CLIN. ENDOCRINOL. & METAB., vol. 85, 2000, pages 4274 - 4279
KABAT E. A. ET AL.: "Sequences of Proteins of Immunological Interest", 1992, PUBLIC HEALTH SERVICE, NIH
PADLAN, MOL. IMMUNOL., vol. 28, 1991, pages 489
HINTON P. R. ET AL., J. BIOL. CHEM., vol. 279, 2004, pages 6213 - 6216
KOEHLER, G. ET AL., NATURE, vol. 256, 1975, pages 495 - 497
HNASKO R. M. ET AL., METHODS MOL. BIOL., vol. 1318, 2015, pages 15 - 28
WINTER G. P. ET AL., ANNU. REV. IMMUNOL., vol. 12, 1994, pages 433 - 455
ROTHE C. ET AL., J. MOL. BIOL., vol. 376, 2008, pages 1182 - 1200
DREIER B. ET AL., METHODS MOL. BIOL., vol. 1827, 2018, pages 235 - 268
YAMAGUCHI J. ET AL., NUCLEIC ACIDS RES., vol. 37, 2009, pages e108
ZHOU C. ET AL., METHODS MOL. BIOL., vol. 907, 2012, pages 293 - 302
LOVE J. C. ET AL., NAT. BIOTECHNOL., vol. 24, 2006, pages 703 - 707
TILLER T. ET AL., J. IMMUNOL. METHODS, vol. 29, 2008, pages 112 - 124
JIN A. ET AL., NAT. MED., vol. 15, 2009, pages 1088 - 1092
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MORRISON S. L., PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 6851 - 6855
QUEEN C. L., PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 10029 - 10033
TSURUSHITA N. ET AL., METHODS, vol. 36, 2005, pages 69 - 83
CHOI Y. ET AL., MABS, vol. 7, 2015, pages 1045 - 1057
RIECHMANN L., NATURE, vol. 322, 1988, pages 323 - 327
GREEN L. L. ET AL., NAT. GENET., vol. 7, 1994, pages 13 - 21
LONBERG N. ET AL., NATURE, vol. 368, 1994, pages 856 - 859
MENDEZ M. J. ET AL., NAT. GENET., vol. 15, 1997, pages 146 - 156
ISHIDA I. ET AL., CLONING STEM CELLS, vol. 4, 2002, pages 91 - 102
OSBORN M. J. ET AL., J. IMMUNOL., vol. 190, 2013, pages 1481 - 1490
LEE E. C. ET AL., NAT. BIOTECHNOL., vol. 32, 2014, pages 356 - 363
MURPHY A. J. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 111, 2014, pages 5153 - 5158
QUEEN C. ET AL., IMMUNOL. REV., vol. 89, 1986, pages 49 - 68
OSSIPOW V. ET AL.: "Methods Mol. Biol.", vol. 1131, 2014, article "Monoclonal Antibodies"
PERDIGONES A. S. ET AL., CELL ENGINEERING, vol. 7, 2011, pages 143 - 164
POLLOCK D. P. ET AL., J. IMMUNOL. METHODS, vol. 231, 1999, pages 147 - 157
ZAO Y. ET AL., PROTEIN EXPRESSION AND PURIFICATION, vol. 67, 2009, pages 182 - 189
OMAE Y. ET AL., ENDOCRINOL JAPON, vol. 36, 1989, pages 9 - 13
ASTON, R. ; COOPER, L. ; HOLDER, A. ; IVANYI, J. ; PREECE, M.: "Monoclonal antibodies to human growth hormone can distinguish between pituitary and genetically engineered forms", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 22, no. 3, 1 March 1985 (1985-03-01), GB , pages 271 - 275, XP023852689, ISSN: 0161-5890, DOI: 10.1016/0161-5890(85)90161-0
AMIT, T. ; BARKEY, R.J. ; YOUDIM, M.B.H. ; HOCHBERG, Z.: "Modulation of human growth hormone binding to somatogenic and lactogenic receptors by monoclonal antibodies to human growth hormone", CELLULAR SIGNALLING., ELSEVIER SCIENCE LTD., GB, vol. 4, no. 5, 1 September 1992 (1992-09-01), GB , pages 553 - 558, XP025582014, ISSN: 0898-6568, DOI: 10.1016/0898-6568(92)90024-3
PALO E. F. D.: "Growth hormone isoforms and segments/fragments: Molecular structure and laboratory measurement", CLINICA CHIMICA ACTA, vol. 364, 2006, pages 67 - 76, XP025058826, DOI: 10.1016/j.cca.2005.06.009
BOGUSZEWSKI C. L. ET AL.: "Cloning of two novel growth hormone transcripts expressed in human placenta", J CLIN ENDOCRINOL METAB, vol. 83, 1998, pages 2878 - 2885, XP002284754, DOI: 10.1210/jc.83.8.2878
LU M. ET AL.: "Targeting growth hormone function: strategies and therapeutic applications", SIGNAL TRANSDUCTION AND TARGETED THERAPY, vol. 4, 2019, pages 3, XP055886716, DOI: 10.1038/s41392-019-0036-y
JO K PERRY ET AL.: "Tumour-Derived Human Growth Hormone As a Therapeutic Target in Oncology", TRENDS ENDOCRINOL METAB, vol. 28, no. 8, 2017, pages 587 - 596, XP085134414, DOI: 10.1016/j.tem.2017.05.003
I E MCCUTCHEON ET AL.: "Antitumor activity of the growth hormone receptor antagonist pegvisomant against human meningiomas in nude mice", J NEUROSURG., vol. 94, 2001, pages 487 - 492
P ANIL KUMAR ET AL.: "The glomerular podocyte as a target of growth hormone action: implications for the pathogenesis of diabetic nephropathy", CURR DIABETES REV., vol. 7, no. 1, 2011, pages 50 - 55
SHLOMO MELMED: "Medical progress: Acromegaly", N ENGL J MED, vol. 355, 2006, pages 2558 - 2573
CAROLINE LEGER ET AL.: "Adenovirus-mediated gene transfer of hIGF-IB in mouse lungs induced prolonged inflammation but no fibroproliferation", AM J PHYSIOL LUNG CELL MOL PHYSIOL., vol. 298, no. 4, 2010, pages 492 - 500
IVANYI J.: "Study of antigenic structure and inhibition of activity of human growth hormone and chorionic somatomammotropin by monoclonal antibodies", MOL. IMMUNOL., vol. 19, 1982, pages 1611 - 1618, XP023680901, DOI: 10.1016/0161-5890(82)90272-3
BURBRIDGE D. ET AL.: "Actions of monoclonal antibodies on the activity of human growth hormone (GH) in an in vitro bioassay", MOL. CELL. ENDOCRINOL., vol. 174, 2001, pages 11 - 19
MELLADO M. ET AL.: "Characterization of monoclonal antibodies specific for the human growth hormone 22K and 20K isoforms", J. CLIN. ENDOCRINOL. METAB., vol. 81, 1996, pages 1613 - 1618, XP000983139, DOI: 10.1210/jc.81.4.1613
ROGUIN L. P.: "Monoclonal antibodies to human growth hormone modulate its biological properties ", IMMUNOL., vol. 32, 1995, pages 399 - 405
LATTUADA D.: "Monoclonal antibodies against recombinant human growth hormone as probes to study immune function.", HYBRIDOMA, vol. 15, 1996, pages 211 - 217, XP009066561
SATO Y. ET AL.: "Characterization of monoclonal antibodies to human growth hormone (hGH", TOKYO JOSHI IKA DAIGAKU ZASSHI, vol. 54, 1984, pages 493 - 506
ISHIKAWA M. ET AL.: "Novel Specific Bioassay for Serum Human Growth Hormone", J. CLIN. ENDOCRINOL. & METAB., vol. 85, 2000, pages 4274 - 4279
KABAT E. A. ET AL.: "Sequences of Proteins of Immunological Interest", 1992, PUBLIC HEALTH SERVICE, NIH
PADLAN, MOL. IMMUNOL., vol. 28, 1991, pages 489
HINTON P. R. ET AL., J. BIOL. CHEM., vol. 279, 2004, pages 6213 - 6216
KOEHLER, G. ET AL., NATURE, vol. 256, 1975, pages 495 - 497
HNASKO R. M. ET AL., METHODS MOL. BIOL., vol. 1318, 2015, pages 15 - 28
WINTER G. P. ET AL., ANNU. REV. IMMUNOL., vol. 12, 1994, pages 433 - 455
ROTHE C. ET AL., J. MOL. BIOL., vol. 376, 2008, pages 1182 - 1200
DREIER B. ET AL., METHODS MOL. BIOL., vol. 1827, 2018, pages 235 - 268
YAMAGUCHI J. ET AL., NUCLEIC ACIDS RES., vol. 37, 2009, pages e108
ZHOU C. ET AL., METHODS MOL. BIOL., vol. 907, 2012, pages 293 - 302
LOVE J. C. ET AL., NAT. BIOTECHNOL., vol. 24, 2006, pages 703 - 707
TILLER T. ET AL., J. IMMUNOL. METHODS, vol. 29, 2008, pages 112 - 124
JIN A. ET AL., NAT. MED., vol. 15, 2009, pages 1088 - 1092
STARKIE D. O. ET AL., PLOS ONE, vol. 11, 2016, pages 20152282
WINTERS A. ET AL., MABS, vol. 11, 2019, pages 1025 - 1035
JOSEPHIDES D. ET AL., SLAS TECHNOL., vol. 25, 2020, pages 177 - 189
MORRISON S. L., PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 6851 - 6855
QUEEN C. L., PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 10029 - 10033
TSURUSHITA N. ET AL., METHODS, vol. 36, 2005, pages 69 - 83
CHOI Y. ET AL., MABS, vol. 7, 2015, pages 1045 - 1057
RIECHMANN L., NATURE, vol. 322, 1988, pages 323 - 327
GREEN L. L. ET AL., NAT. GENET., vol. 7, 1994, pages 13 - 21
LONBERG N. ET AL., NATURE, vol. 368, 1994, pages 856 - 859
MENDEZ M. J. ET AL., NAT. GENET., vol. 15, 1997, pages 146 - 156
ISHIDA I. ET AL., CLONING STEM CELLS, vol. 4, 2002, pages 91 - 102
OSBORN M. J. ET AL., J. IMMUNOL., vol. 190, 2013, pages 1481 - 1490
LEE E. C. ET AL., NAT. BIOTECHNOL., vol. 32, 2014, pages 356 - 363
MURPHY A. J. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 111, 2014, pages 5153 - 5158
QUEEN C. ET AL., IMMUNOL. REV., vol. 89, 1986, pages 49 - 68
OSSIPOW V. ET AL.: "Methods Mol. Biol.", vol. 1131, 2014, article "Monoclonal Antibodies"
PERDIGONES A. S. ET AL., CELL ENGINEERING, vol. 7, 2011, pages 143 - 164
POLLOCK D. P. ET AL., J. IMMUNOL. METHODS, vol. 231, 1999, pages 147 - 157
ZAO Y. ET AL., PROTEIN EXPRESSION AND PURIFICATION, vol. 67, 2009, pages 182 - 189
OMAE Y. ET AL., ENDOCRINOL JAPON, vol. 36, 1989, pages 9 - 13
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KOBAYASHI Hiroshi et al. (JP)
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