CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the priority of US Provisional Patent

Application with serial number No. 62154855, filed on April 30, 2015, with the tile, "Anti Hemorrhoid", and the content of which is incorporated herein by reference in its entirety.

BACKGROUND

Technical field

[0002] The embodiments herein generally relates to the herbal composition.

The embodiments herein particularly relate to a composition for targeting hemorrhoids. The embodiment herein more particularly relate to a herbal composition and method of synthesizing the herbal composition for targeting hemorrhoids.

Description of the Related Art

[0003] Hemorrhoids are a common clinical anorectal disease. Hemorrhoids are vascular structures in the anal canal. The hemorrhoids in their normal state are cushions that help with stool control. The hemorrhoids when swollen or inflamed become pathological or form piles. At this point the condition is technically known as hemorrhoidal disease. The signs and symptoms of hemorrhoids vary from individual to individual.

[0004] Various diseases of the anorectal region of the human body are characterized by inflammation, itching, and ulcerations. The anorectal region is generally comprises of the anus, rectum, and lower colon. In particular, hemorrhoids or piles are a common ailment of the anorectal region, and may be internally or externally located in the anorectal area. The veins in the anorectal area become inflamed and frequently result in itching. The causes of hemorrhoids include predisposing causes such as erect posture, heredity, occupation and diet, constipation, diarrhea, pregnancy, anal infection, pelvic tumors, rectal carcinoma, cardiac failure, portal hypertension, vomiting and physical exertion.

[0005] There are two main types of hemorrhoids: external hemorrhoids and internal hemorrhoids. Internal hemorrhoids are usually present with painless rectal bleeding. While external hemorrhoids exhibit pain and swelling in the area of the anus.

[0006] The internal and external hemorrhoids are different. Bleeding significantly causes anemia in patients. The external hemorrhoids are painful. The pain may persist for 2-3 days. Further the pain id accompanied with swelling of anal canal. The hemorrhoids cause unhygienic condition in anal canal, itchiness around anus and irritation in anal canal.

[0007] The internal hemorrhoids are usually present with painless bright red rectal bleeding during or following a bowel movement. The blood typically covers the stool, or blood is found on tissue paper or blood drips in toilet. The stool itself is usually normally colored, but when hemorrhoids get inflamed then blood is discharged along with stool. Other symptoms include mucous discharge, a peri-anal mass through the anus, itchiness and fecal incontinence. Internal hemorrhoids are usually painful if they become thrombosed or necrotic.

[0008] The exact cause of symptomatic hemorrhoids is unknown. A number of factors are believed to play a role, including: irregular bowel habits (constipation or diarrhea), lack of exercise, nutritional factors (low-fiber diets), increased intra-abdominal pressure (prolonged straining, ascites, an intra-abdominal mass, or pregnancy), genetics, an absence of valves within the hemorrhoidal veins, and aging. Other factors believed to increase risk include obesity, prolonged sitting, a chronic cough, and pelvic floor dysfunction.

[0009] During pregnancy, pressure from the fetus on the abdomen and hormonal changes cause the hemorrhoidal vessels to enlarge. The birth of the baby also leads to increased intra-abdominal pressures. Pregnant women rarely need surgical treatment, as symptoms usually resolve after delivery.

[0010] Further, the treatment of hemorrhoids is complicated by the fact that during defecation, the fecal mass stretches, tears and irritates the already inflamed and swollen hemorrhoidal tissue. Further, as a result of additional muscle strain during defecation resulting from the physical movement of the fecal mass through the already swollen and inflamed tissue, herniation of the anal walls frequently results. Moreover, the excretory tract is the site of numerous organisms that are infectious and infiltrate the anal cavity herniations. This infiltration further damage already damaged tissue and aggravates the healing process. If left untreated hemorrhoids often worsen and require surgery to remove the diseased hemorrhoidal tissue.

[0011] Many remedies are known for the targeting these symptoms. Most of the remedies in the art have varying degrees of success, and few remedies have been successful in the substantially reducing or completely eliminating hemorrhoids without any side effects.

[0012] Conservative treatment typically consists of foods rich in dietary fiber, intake of oral fluids to maintain hydration, non-steroidal anti-inflammatory drugs, sitz baths, and rest. Increased fiber intake has been shown to improve outcomes and may be achieved by dietary alterations or the consumption of fiber supplements. Evidence for complete eradication and benefits from the conservative treatment is lacking.

[0013] A number of office-based procedures may be performed. While generally safe, rare serious side effects such as peri-anal sepsis may occur. Rubber band ligation is typically recommended as the first-line treatment in the patients with grade or stage 1 to 3 of disease. It is a procedure in which elastic bands are applied onto an internal hemorrhoid at least 1 cm above the dentate line to cut off its blood supply. Within 5-7 days, the withered hemorrhoid falls off. If the band is placed too close to the dentate line, intense pain results immediately afterwards. Cure rate has been found to be about 87% with a complication rate of up to 3%. Sclerotherapy involves the injection of a sclerosing agent, such as phenol, into the hemorrhoid. This causes the vein walls to collapse and the hemorrhoids to shrivel up. The success rate four years after treatment is about 70%. A number of cauterization methods have been shown to be effective for hemorrhoids, but are usually only used when other methods fail. This procedure can be done using electrocautery, infrared radiation, laser surgery, or cryosurgery. Infrared cauterization may be an option for grade 1 or 2 disease. In those with grade 3 or 4 disease, reoccurrence rates are high.

[0001] A number of surgical techniques are used if conservative management and simple procedures fail. All surgical treatments are associated with some degree of complications including bleeding, infection, anal structures and urinary retention, due to the close proximity of the rectum to the nerves that supply the bladder. Also, a small risk of fecal incontinence occurs, particularly of liquid, with rates reported between 0% and 28%. There are undesirable side effects of these known treatments.

[0002] In the past there were cases that even after surgery the patient didn't heal but because of some elements such as camazolene. Camazolene is anti flaming- and Linoleic acid which is disinfectant and heals severe injuries. The other treatments in the market are creams which are macromolecules. The macromolecules are less absorbable by body tissues.

[0003] These undesirable side effects of these treatments prevent patients from obtaining adequate relief.

[0004] Hence, there is a need for a treatment for hemorrhoids that substantially or completely eliminates hemorrhoids. Also there is a need for a simple herbal composition which eliminates hemorrhoids while being free of undesirable side effects associated with the treatment. Further there is a need for a simple method to synthesize the herbal composition for treating hemorrhoids.

[0005] The above mentioned shortcomings, disadvantages and problems are addressed herein and which will be understood by reading and studying the following specification.

OBJECTIVES OF THE EMBODIMENTS

[0006] The primary objective of the embodiment herein is to provide anti- hemorrhoidal herbal compositions for the treatment of external hemorrhoids, internal hemorrhoids and constipation.

[0007] Another object of the embodiment herein is to provide a simple method for the synthesis of anti- hemorrhoidal herbal compositions for the treatment of external hemorrhoids, internal hemorrhoids and constipation.

[0008] Yet another object of the embodiment herein is to provide a low cost anti- hemorrhoidal herbal compositions for the treatment of external hemorrhoids, internal hemorrhoids and constipation.

[0009] Yet another object of the embodiment herein is to provide anti- hemorrhoidal herbal compositions for the treatment of external hemorrhoids, internal hemorrhoids and constipation having no side effects.

[0010] Yet another object of the embodiment herein is to provide anti- hemorrhoidal herbal compositions for the treatment of external hemorrhoids, internal hemorrhoids and constipation which are cheap when compared to existing therapies.

[0011] Yet another object of the embodiment herein is to synthesize herbal spray for the treatment of external hemorrhoids.

[0012] Yet another object of the embodiment herein is to synthesize herbal spray for the treatment of internal hemorrhoids.

[0013] Yet another object of the embodiment herein is to synthesize herbal oil for the treatment of constipation.

[0014] Yet another object of the embodiment herein is to provide anti- constipation oil which regulates constipation through peristalsis of intestine, anal cavity, tranquilizes pain and makes the stool to pass without any difficulty.

[0015] Yet another object of the embodiment herein is to provide anti- hemorrhoidal herbal compositions for the treatment of external hemorrhoids, internal hemorrhoids and constipation which eliminate the causes of hemorrhoids.

[0016] Yet another object of the embodiment herein is to provide anti- hemorrhoidal herbal compositions for the treatment of external hemorrhoids, internal hemorrhoids and constipation which inhibit pressure on anus and rectum so that there is no pain and bleeding.

[0017] Yet another object of the embodiment herein is to provide anti- hemorrhoidal herbal compositions for the treatment of external hemorrhoids, internal hemorrhoids and constipation which are suitable for patients of all age groups and administered easily.

[0018] Yet another object of the embodiment herein is to provide anti- hemorrhoidal herbal compositions for the treatment of external hemorrhoids, internal hemorrhoids and constipation which can be used or administered in homes, clinics and medical centers.

[0019] These objects and the other advantages of the embodiments herein will become readily apparent from the following detailed description taken in conjunction with the accompanying drawings.

SUMMARY

[0001] The various embodiments herein provide anti- hemorrhoidal herbal compositions for the treatment of external hemorrhoids, internal hemorrhoids and constipation. The embodiments herein also provide a simple method for the synthesis of anti- hemorrhoidal herbal compositions for the treatment of external hemorrhoids, internal hemorrhoids and constipation.

[0002] According to one embodiment herein, the method of synthesizing a plurality of herbal compositions for targeting haemorrhoids, the method comprises the following steps. The herbal spray composition for external haemorrhoids is synthesized. The herbal spray composition is sprayed or applied on the external haemorrhoids. The herbal mixture for internal hemorrhoids is synthesized. The herbal mixture is injected or applied on the internal hemorrhoids. An anti-constipation topical oil is synthesized. The anti- constipation topical oil is injected for a constipation relief. The herbal spray composition for external hemorrhoids is a mixture comprising the extracts of Matricaria recutita, Melilotus officinalis, Crocus sativus stigma extract, linseed enamel and thickened grape juice. The herbal mixture for internal hemorrhoids is a mixture comprising extracts of Matricaria recutita flower, Allium porrum shoot and Apium graveolens stalk. The anti-constipation topical oil is a mixture comprising Sesamum indicum oil and the Ricinus communis oil.

[0003] According to one embodiment herein, the method for synthesizing the herbal spray composition for external hemorrhoids comprises the following steps. The Matricaria recutita flowers and Melilotus officinalis flowers are cleaned to remove contaminants. The Matricaria recutita flowers and Melilotus officinalis flowers are milled separately to obtain Matricaria recutita flower powder and Melilotus officinalis flower powder. The Crocus sativus stigmas are grinded separately and extracting the stigma extract. The Matricaria recutita flower powder in a preset quantity is mixed with a preset quantity of hydrochloric solvent separately. The Matricaria recutita flower powder and the hydrochloric solvent are mixed in a ratio of 1 :3. The quantity of the hydrochloric solvent is 30%v/v. The Matricaria recutita flower powder solution is obtained. The Melilotus officinalis flower powder is mixed in a preset ratio with a preset ratio of hydrochloric solvent separately. The Melilotus officinalis flower powder and the hydrochloric solvent are mixed in a ratio of 1 :3. The quantity of the hydrochloric solvent is 30%v/v. The Melilotus officinalis flower powder solution is obtained. The extracts of Matricaria recutita flower powder and Melilotus officinalis flower powder are obtained after incubating the Matricaria recutita flower powder solution and Melilotus officinalis flower powder solution in a steam distillation apparatus for four days. The extracts of Matricaria recutita, Melilotus officinalis and Crocus sativus stigma extract are mixed to obtain the herbal extract mixture. The herbal extract mixture is blended in a blender to obtain a homogeneous mixture. The linseed enamel and thickened grape juice are added to the herbal extract mixture while blending. The mixture is obtained comprising the extracts of Matricaria recutita, Melilotus officinalis, Crocus sativus stigma extract, linseed enamel and thickened grape juice. The mixture is filtered. The mixture is pasteurized. The herbal extract mixture is stored in containers. The containers are a polyethylene terephthalate (PET) containers.

[0004] According to one embodiment herein, the herbal spray composition for external hemorrhoids is negative for the growth of plurality of bacterial species. The bacterial species are Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus.

[0005] According to one embodiment herein, for the synthesis of the herbal spray composition for external haemorrhoids Matricaria recutita extract is mixed in a preset quantity with a Melilotus officinalis extract in a preset quantity and with a Crocus sativus extract in a preset quantity. The Matricaria recutita extract is mixed in a preset quantity of 8.4 ml. The Melilotus officinalis extract is mixed in a preset quantity of 1.4 ml. The Crocus sativus extract is mixed in a preset quantity of 0.2 ml.

[0006] According to one embodiment herein, the herbal spray composition for external haemorrhoids is an anti-inflammatory agent. The herbal spray composition for external haemorrhoids is an anti-crack agent. The herbal spray composition for external haemorrhoids relieves myalgia. The herbal spray composition for external hemorrhoids removes external inflammations through lymphatic vessels recovery. The herbal spray composition for external haemorrhoids prevents chronic wounds. The herbal extract mixture for external hemorrhoids comprises of small molecules. The small molecules of the herbal extract spray get absorbed and penetrate in skin/tissue layers.

[0007] According to one embodiment herein, the herbal spray composition for external hemorrhoids is applied or administered twice a day on the area of the wound or hemorrhoids. The herbal composition for external hemorrhoids or spray is sprayed/ administered at a quantity of 2ml on the anus twice a day. The external hemorrhoids treatment spray is preferably sprayed/ administered once in the morning and once at night.

[0008] According to one embodiment herein, the colour of the herbal spray composition for external haemorrhoids is pale yellow to light brown. The density of the herbal composition for external haemorrhoids is 0.94-0.98 g/cm ³ . The pH of the herbal composition for external haemorrhoids is 3.02-4.67. The average volume of the herbal composition for external haemorrhoids is 55 ml. The herbal composition for external haemorrhoids is opaque. The viscosity of the herbal composition for external haemorrhoids is 5.63 m ² /s. The amount of the active constituent in the herbal composition for external haemorrhoids is 0.025% w/w.

[0009] According to one embodiment herein, the amount of flavonoids in the herbal spray composition for external haemorrhoids is 0.025% w/w.

[0010] According to one embodiment herein, the method for synthesizing the herbal mixture/spray composition for internal haemorrhoids comprises of the following steps. The Matricaria recutita flower, Allium porrum shoot and Apium graveolens stalk are cleaned to remove contaminants. The Matricaria recutita flower powder, Allium porrum shoot powder and Apium graveolens stalk powder are obtained after milling the Matricaria recutita flower, Allium porrum shoot and Apium graveolens stalk separately. The Matricaria recutita flower powder is mixed in a preset ratio with a preset ratio of a solvent. The Matricaria recutita flower powder and the solvent are mixed in a ratio of 1 :3. The solvent is water. The solution of Matricaria recutita flower powder is obtained. The Allium porrum shoot powder is mixed in a preset ratio with a preset ratio of a solvent. The Allium porrum shoot powder and the solvent are mixed in a ratio of 1 :3. The solvent is water. The solution of Allium porrum shoot powder is obtained. The Apium graveolens stalk powder is mixed in a preset ratio with a preset ratio of a solvent. The Apium graveolens stalk powder and the solvent are mixed in a ratio of 1 :3. The solvent is water. The solution of Apium graveolens stalk powder is obtained. The solutions of Matricaria recutita flower powder, Allium porrum shoot powder and Apium graveolens stalk powder are heated separately for 4 hours. The solutions of Matricaria recutita flower powder, Allium porrum shoot powder and Apium graveolens stalk powder are filtered after 4 hours. The filtrate is obtained. The filtrate comprises of herbal extracts of Matricaria recutita flower, Allium porrum shoot and Apium graveolens stalk. The herbal extracts of Matricaria recutita flower, Allium porrum shoot and Apium graveolens stalk extract are mixed to get a mixture. The honey is added to the mixture to obtain herbal extract mixture. The herbal extract mixture is blended in a mixer to attain consistency. The herbal extract mixture is filtered and pasteurized. The herbal extract mixture is stored in containers. The containers are polyethylene terephthalate (PET) containers. [0011] According to one embodiment herein, for the synthesis of the herbal mixture/spray composition for internal haemorrhoids Matricaria recutita flower extract is mixed with Allium porrum shoot extract, Apium graveolens stalk extract and honey. The Matricaria recutita flower extract is mixed in preset quantity of 3.65 ml. T e Allium porrum shoot extract is mixed in preset quantity of 3.15 ml. The Apium graveolens stalk extract is mixed in preset quantity of 2.75 ml. The honey is mixed in preset quantity of 0.45 ml.

[0012] According to one embodiment herein, the herbal mixture/spray composition for internal hemorrhoids is laxative agent. The herbal spray composition for internal haemorrhoids is tranquilizer agent. The herbal spray composition for internal haemorrhoids is anti-bleeding agent. The herbal spray composition for internal haemorrhoids is intestinal antiseptic. The herbal spray composition for internal haemorrhoids is internal wound tranquilizer. The herbal spray composition for internal haemorrhoids removes internal swelling. The herbal extract mixture for internal hemorrhoid comprises of small molecules. The small molecules of the herbal extract spray get absorbed and penetrate in skin/tissue layers. The herbal extract mixture for internal hemorrhoid makes defecation easy without difficulty. The herbal extract mixture for internal hemorrhoid regulates intestinal peristalsis and heals wounds.

[0013] According to one embodiment herein, the herbal mixture/spray composition for internal hemorrhoids is applied or administered twice a day on the area of the wound or hemorrhoids. The herbal composition for external hemorrhoids or spray is administered or injected in anus in a quantity of 2ml on the anus twice a day. Preferably the internal hemorrhoid treatment spray is sprayed/ administered once in the morning and once at night. [0014] According to one embodiment herein, the colour of the herbal composition mixture/spray for internal haemorrhoids is cream. The density of the herbal composition for internal haemorrhoids is 0.99 g/cm ³ . The pH of the herbal composition for internal haemorrhoids is 2.89. The average volume of the herbal composition for internal haemorrhoids is 110 ml. The herbal composition for internal haemorrhoids is transparent. The viscosity of the herbal composition for internal haemorrhoids is 9.98 m ² /s. The amount of the active constituent in the herbal composition for internal haemorrhoids is 0.013% w/w.

[0015] According to one embodiment herein, the amount of flavonoids in the herbal composition for internal haemorrhoids is 0.013% w/w.

[0016] According to one embodiment herein, the method for synthesizing the anti-constipation topical oil for constipation comprises the following steps. The sesame seeds and castor seeds are cleaned to remove contaminants. The sesame seeds are crushed for extracting sesame seed shells and obtaining seed kernels. A dough is synthesized from the sesame seed kernel. The pressure is applied to the sesame seed kernel dough at a low temperature. The oil is extracted from the sesame seed kernel dough by cold pressing. The concentration of extracted oil from sesame seed kernel dough is 38-50% v/v. The castor seed shells are removed to obtain the castor seeds. The hydraulic pressure is applied on castor oil seeds in a low temperature for extracting castor oil. The castor oil is refined. The concentration of refined castor oil is 33% v/v. The sesame seed oil and the castor oil are mixed to obtain an oil mixture. The oil mixture is blended to attain uniform consistency. The oil mixture is filtered. The oil mixture is stored in containers. The containers are polyethylene terephthalate (PET) containers. [0017] According to one embodiment herein, for the synthesis of the anti- constipation topical oil for constipation Sesamum indicum oil is mixed with the Ricinus communis oil. The Sesamum indicum oil is mixed in a preset quantity of 60% v/v. The Ricinus communis oil is mixed in a preset quantity of 40% v/v.

[0018] According to one embodiment herein, the anti-constipation topical oil for constipation is administered in a quantity of 2 ml. The anti-constipation topical oil is injected into anus by a syringe. Preferably the anti-constipation topical oil is administered in the morning and at midnight.

[0019] According to one embodiment herein, the anti-constipation topical oil is negative for the growth of plurality of bacterial species. The bacterial species are Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus.

[0020] According to one embodiment herein, the colour of the herbal composition for anti-constipation topical oil is cream. The density of the anti-constipation topical oil is 0.89 g/cm ³ . The pH of the anti-constipation topical oil is 4.46. The average weight of the anti-constipation topical oil is 25 ml. The viscosity of the anti-constipation topical oil is 2690 m ² /s. The amount of acidity of anti-constipation topical oil is 2.24.

[0021] According to one embodiment herein, the anti-constipation topical oil is laxative agent. The anti-constipation topical oil is healing agent. The anti-constipation topical oil is tranquilizer. The anti-constipation topical oil makes defecation smooth. The anti-constipation topical oil stops pressure on anus and rectum. The anti-constipation topical oil relieves pain and stops bleeding.

[0022] According to one embodiment herein, the integrated herbal composition for targeting haemorrhoids with plurality or combination of herbal compositions comprises of the following. A herbal spray composition for external haemorrhoids, a herbal mixture composition for internal haemorrhoids and an anti-constipation topical oil.

[0023] According to one embodiment herein, in the composition of herbal spray composition for external haemorrhoids comprises Matricaria recutita extract, Melilotus officinalis extract, and Crocus sativus extract. The Matricaria recutita extract is present in a preset quantity of 8.4 ml. The Melilotus officinalis extract is present in a preset quantity of 1.4 ml. The Crocus sativus extract is present in a preset quantity of 0.2 ml.

[0024] According to one embodiment herein, the herbal spray composition for external hemorrhoids is negative for the growth of plurality of bacterial species. The bacterial species are Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus.

[0025] According to one embodiment herein, the herbal spray composition for external hemorrhoids is anti- inflammatory agent. The herbal spray composition for external haemorrhoids is anti-crack agent. The herbal spray composition for external haemorrhoids relieves myalgia. The herbal spray composition for external haemorrhoids removes external inflammations through lymphatic vessels recovery. The herbal spray composition for external haemorrhoids prevents chronic wounds. The herbal extract mixture for external hemorrhoid comprises of small molecules. The small molecules of the herbal extract spray get absorbed and penetrate in skin/tissue layers.

[0026] According to one embodiment herein, the colour of the herbal composition for external haemorrhoids is pale yellow to light brown. The density of the herbal composition for external haemorrhoids is 0.94-0.98 g/cm ³ . The pH of the herbal composition for external haemorrhoids is 3.02-4.67. The average volume of the herbal composition for external haemorrhoids is 55 ml. The herbal composition for external haemorrhoids is opaque. The viscosity of the herbal composition for external haemorrhoids is 5.63 m ² /s. The amount of the active constituent in the herbal composition for external haemorrhoids is 0.025% w/w.

[0027] According to one embodiment herein, the amount of flavonoids in the herbal composition for external haemorrhoids is 0.025% w/w.

[0028] According to one embodiment herein, the composition of herbal mixture/spray composition for internal haemorrhoids comprises Matricaria recutita flower extract, a Allium porrum shoot extract, a Apium graveolens stalk extract and honey. The Matricaria recutita flower extract is present in preset quantity of 3.65 ml. The, Allium porrum shoot extract is present in preset quantity of 3.15 ml. The, Apium graveolens stalk extract is present in preset quantity of 2.75 ml. The honey is present in a preset quantity of 0.45 ml.

[0029] According to one embodiment herein, the herbal mixture/spray composition for internal hemorrhoids is laxative agent. The herbal mixture/spray composition for internal haemorrhoids is tranquilizer agent. The herbal mixture/spray composition for internal haemorrhoids is anti-bleeding agent. The herbal mixture/spray composition for internal haemorrhoids is intestinal antiseptic. The herbal mixture/spray composition for internal haemorrhoids is internal wound tranquilizer. The herbal mixture/spray composition for internal haemorrhoids removes internal swelling. The herbal extract mixture/spray for internal hemorrhoid comprises of small molecules. The small molecules of the herbal extract spray get absorbed and penetrate in skin/tissue layers. The herbal extract mixture/spray for internal hemorrhoid makes defecation easy without difficulty. The herbal extract mixture for internal hemorrhoid regulates intestinal peristalsis and heals wounds.

[0030] According to one embodiment herein, the colour of the herbal mixture/spray composition for external haemorrhoids is cream. The density of the herbal composition for internal haemorrhoids is 0.99 g/cm ³ . The pH of the herbal composition for internal haemorrhoids is 2.89. The average volume of the herbal composition for internal haemorrhoids is 110 ml. The herbal composition for external haemorrhoids is transparent. The viscosity of the herbal composition for internal haemorrhoids is 9.98 m ² /s. The amount of the active constituent in the herbal composition for internal haemorrhoids is 0.013% w/w.

[0031] According to one embodiment herein, the amount of flavonoids in the herbal mixture/spray composition for internal haemorrhoids is 0.013% w/w.

[0032] According to one embodiment herein, the anti-constipation topical oil for constipation comprises Sesamum indicum oil, Ricinus communis oil. The Sesamum indicum oil is present in preset quantity of 60% v/v. The Ricinus communis oil is present in preset quantity of 40% v/v.

[0033] According to one embodiment herein, the anti-constipation topical oil is negative for the growth of plurality of bacterial species. The bacterial species are Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus.

[0034] According to one embodiment herein, the colour of the herbal composition for anti-constipation topical oil is cream. The density of the anti-constipation topical oil is 0.89 g/cm ³ . The pH of the anti-constipation topical oil is 4.46. The average weight of the anti-constipation topical oil is 25 ml. The viscosity of the anti-constipation topical oil is 2690 m ² /s. The amount of acidity of anti-constipation topical oil is 2.24. [0035] According to one embodiment herein, the anti-constipation topical oil is a laxative agent. The anti-constipation topical oil is healing agent. The anti-constipation topical oil is tranquilizer. The anti-constipation topical oil makes defecation smooth. The anti-constipation topical oil stops pressure on anus and rectum. The anti-constipation topical oil relieves pain and stops bleeding.

[0036] According to one embodiment herein, there are three medicines for the treatment of external hemorrhoids, internal hemorrhoids and constipation. 1) a herbal spray for external hemorrhoids. Administering the external spray twice a day resolves the clots and stops bleeding.2) a herbal mixture for internal hemorrhoids. Injecting (2 ml) of the herbal mixture into the anus stops bleeding that is caused by constipation, heals internal swelling, eases the act of defecation and recovers the injuries inside the rectum.3) topical oil for constipation. Injecting (3ml) of this oil into the anus soften the skin and helps the recovery of cracks inside the anus. By soothing rectum, the oil relieves the pressure on the rectum and anus.

[0037] According to one embodiment herein, the external hemorrhoid treatment spray comprises of herbal extracts from Matricaria recutita (Chamoline) flower, Crocus sativus (Saffron) stigma and Melilotus officinalis (Yellow sweet clover) flower. The herbal extracts from Matricaria recutita flower and Melilotus officinalis flower are extracted through steam distillation. The herbal extracts from the flowers of Matricaria recutita and Melilotus officinalis are obtained mixed. The Crocus sativus stigma's herbal extract is added to the mixture of flower extracts of Matricaria recutita and Melilotus officinalis to obtain a herbal extract mixture. The herbal extract mixture is blended in a mixer till the extract molecules become completely consistence and to obtain the extract mixture. The repository is filled with the herbal extract mixture. The herbal extract mixture is stored in containers. The herbal extract mixture is administered as spray for external hemorrhoids. For the production of 50000mg of this liquid 42000mg of Matricaria recutita extract, (lOOOmg) Crocus sativus extract and (7000mg) Melilotus officinalis extract is mixed. The herbal extracts in the spray relieves myalgia, removes external inflammations through lymphatic vessels recovery, and prevents the chronic wounds. The herbal extracts also act as an anti inflammation and anti crack spray.

[0038] According to one embodiment herein, the herbal spray is applied or administered twice a day on the area of the wound or hemorrhoids. The area of wound must become wet after the application of the extract mixture. The extract mixture comprises of small molecules. The small molecules of the herbal extract spray get absorbed and penetrates in skin/tissue layers quickly. The camazolene in the Matricaria recutita and the vitamins that exist in the plants recover the wounds. This spray for external hemorrhoids is used at home, clinics, medical centers, and private centers easily. Further spray for external hemorrhoids is administered to any patient irrespective of the age of patients. The spray doesn't have any side effects. The plant resources in Iran are abundant. Hence the external spray for hemorrhoids is very economic.

[0039] According to one embodiment herein, the internal hemorrhoid herbal treatment composition comprises of extracts from Matricaria recutita (Chamoline) flower, Allium porrum (Leek) shoot and Apium graveolens (Celery) stalk. The herbal extracts from the aforementioned plants is mixed with honey. For the synthesis of internal hemorrhoid herbal treatment composition the extracts of Matricaria recutita flower, Allium porrum shoot extract and Apium graveolens stalk extract are obtained through steam distillation. After obtaining the extracts, the extracts are mixed to obtain a herbal extract mixture. Honey (without its wax) is added to the herbal extract mixture and mixed in the mixer till the molecules become completely consistence. The herbal extract mixture for internal hemorrhoid is obtained. The herbal extract mixture for internal hemorrhoid is filled in special containers and kept in the repository. To produce (HOOOmg) of herbal extract mixture for internal hemorrhoid 40000mg Matricaria recutita extract, 35000mg of Allium porrum extract, 30000mg Apium graveolens extract and 5000mg honey are mixed. This herbal extract mixture for internal hemorrhoid is laxative, tranquilizer, anti bleeding agent, intestinal antiseptic, and internal wound tranquilizer and removes internal swelling. This herbal extract mixture for internal hemorrhoid makes defecation easy without difficulty and this result in patients' recovery.

[0040] According to one embodiment herein, the herbal extract mixture for internal hemorrhoid is administered in a quantity of 2 ml. The herbal extract mixture for internal hemorrhoid is administered by injecting in the Anus every 12 hours. The herbal extract mixture for internal hemorrhoid comprises of small molecules. The small molecules of the herbal extract spray get absorbed and penetrates in skin/tissue layers quickly. The camazolene in the matricaria and the other vitamins that exist in the plants recover the wounds and swellings of anus and makes defecation easy by regulating the intestinal peristalsis. This spray for internal hemorrhoids is used at home, clinics, medical centers, and private centers easily. Further spray for internal hemorrhoids is administered to any patient irrespective of the age of patients. The spray doesn't have any side effects. The plant resources in Iran are abundant. Hence the external spray for hemorrhoids is very economic. [0041] According to one embodiment herein, the anti-constipation oil comprises of mixture of Sesamum indicum (Sesame) oil and Ricinus communis (Castor oil plant) oil. To make (50000mg) of this topical anti constipation oil mixture 30000mg Sesamum indicum (60%v/v) and 20000mg castor oil 40% v/v oil is mixed.

[0042] According to one embodiment herein, for the synthesis of anti- constipation oil mixture, the sesame seeds are cleaned. After cleaning, the sesame seeds are crushed for extracting the shells. The seed kernals are obtained after removing the seed shells. The seed kernels are turned into dough. The seed kernel dough is put under pressure in low temperature condition. This process is called cold pressing and extracts about 38-50% oil from sesame seeds. For extracting the castor oil the castor seed shells are removed. The seeds obtained after removing shells are kept under hydraulic pressure in low temperature condition. After refining 33% castor oil obtained.

[0043] The sesame seed oil and the castor oil are mixed. The oil mixture is blended in a mixer till the extract molecules become completely consistence and to obtain the extract mixture. The repository is filled with the oil mixture. The herbal extract mixture is stored in containers. The oil mixture is laxative, healing agent, tranquilizer and it makes stool passing without difficulty and stops pressure on the anus and rectum so there is no pain and bleeding.

[0044] These and other aspects of the embodiments herein will be better appreciated and understood when considered in conjunction with the following description and the accompanying drawings. It should be understood, however, that the following descriptions, while indicating preferred embodiments and numerous specific details thereof, are given by way of illustration and not of limitation. Many changes and modifications may be made within the scope of the embodiments herein without departing from the spirit thereof, and the embodiments herein include all such modifications.

BRIEF DESCRIPTION OF THE DRAWINGS

[0045] The other objects, features and advantages will occur to those skilled in the art from the following description of the preferred embodiment and the accompanying drawings in which:

[0046] FIG.l illustrates a flow chart indicating a method for synthesizing herbal spray for external hemorrhoids, according to one embodiment herein.

[0047] FIG.2 illustrates an image indicating the anti-microbial analysis report of herbal spray for external hemorrhoids, according to one embodiment herein.

[0048] FIG. 3 illustrates an image indicating the physiochemical analysis report of herbal spray for external hemorrhoids, according to one embodiment herein.

[0049] FIG.4 illustrates a flow chart indicating a method for synthesizing herbal composition for internal hemorrhoids, according to one embodiment herein.

[0050] FIG.5 illustrates an image indicating the physiochemical analysis report of composition for internal hemorrhoids, according to one embodiment herein.

[0051] FIG.6 illustrates a flow chart indicating a method for synthesizing anti-constipation topical oil, according to one embodiment herein.

[0052] FIG.7 illustrates an image indicating the anti-microbial analysis report of anti-constipation topical oil, according to one embodiment herein.

[0053] Although the specific features of the embodiments herein are shown in some drawings and not in others. This is done for convenience only as each feature may be combined with any or all of the other features in accordance with the embodiments herein.

DETAILED DESCRIPTION OF THE EMBODIMENTS

[0054] In the following detailed description, a reference is made to the accompanying drawings that form a part hereof, and in which the specific embodiments that may be practiced is shown by way of illustration. The embodiments are described in sufficient detail to enable those skilled in the art to practice the embodiments and it is to be understood that the logical, mechanical and other changes may be made without departing from the scope of the embodiments. The following detailed description is therefore not to be taken in a limiting sense.

[0055] The various embodiments herein provide provide anti- hemorrhoidal herbal compositions for the treatment of external hemorrhoids, internal hemorrhoids and constipation. The embodiments herein also provide a simple method for the synthesis of anti- hemorrhoidal herbal compositions for the treatment of external hemorrhoids, internal hemorrhoids and constipation.

[0056] According to one embodiment herein, the method of synthesizing a plurality of herbal compositions for targeting haemorrhoids, the method comprises the following steps. The herbal spray composition for external haemorrhoids is synthesized. The herbal spray composition is sprayed or applied on the external haemorrhoids. The herbal mixture for internal hemorrhoids is synthesized. The herbal mixture is injected or applied on the internal hemorrhoids. An anti-constipation topical oil is synthesized. The anti- constipation topical oil is injected for a constipation relief. The herbal spray composition for external hemorrhoids is a mixture comprising the extracts of Matricaria recutita, Melilotus officinalis, Crocus sativus stigma extract, linseed enamel and thickened grape juice. The herbal mixture for internal hemorrhoids is a mixture comprising extracts of Matricaria recutita flower, Allium porrum shoot and Apium graveolens stalk. The anti-constipation topical oil is a mixture comprising Sesamum indicum oil and the Ricinus communis oil.

[0057] According to one embodiment herein, the method for synthesizing the herbal spray composition for external hemorrhoids comprises the following steps. The Matricaria recutita flowers and Melilotus officinalis flowers are cleaned to remove contaminants. The Matricaria recutita flowers and Melilotus officinalis flowers are milled separately to obtain Matricaria recutita flower powder and Melilotus officinalis flower powder. The Crocus sativus stigmas are grinded separately and extracting the stigma extract. The Matricaria recutita flower powder in a preset quantity is mixed with a preset quantity of hydrochloric solvent separately. The Matricaria recutita flower powder and the hydrochloric solvent are mixed in a ratio of 1 :3. The quantity of the hydrochloric solvent is 30%v/v. The Matricaria recutita flower powder solution is obtained. The Melilotus officinalis flower powder is mixed in a preset ratio with a preset ratio of hydrochloric solvent separately. The Melilotus officinalis flower powder and the hydrochloric solvent are mixed in a ratio of 1 :3. The quantity of the hydrochloric solvent is 30%v/v. The Melilotus officinalis flower powder solution is obtained. The extracts of Matricaria recutita flower powder and Melilotus officinalis flower powder are obtained after incubating the Matricaria recutita flower powder solution and Melilotus officinalis flower powder solution in a steam distillation apparatus for four days. The extracts of Matricaria recutita, Melilotus officinalis and Crocus sativus stigma extract are mixed to obtain the herbal extract mixture. The herbal extract mixture is blended in a blender to obtain a homogeneous mixture. The linseed enamel and thickened grape juice are added to the herbal extract mixture while blending. The mixture is obtained comprising the extracts of Matricaria recutita, Melilotus officinalis, Crocus sativus stigma extract, linseed enamel and thickened grape juice. The mixture is filtered. The mixture is pasteurized. The herbal extract mixture is stored in containers. The containers are a polyethylene terephthalate (PET) containers.

[0058] According to one embodiment herein, the herbal spray composition for external hemorrhoids is negative for the growth of plurality of bacterial species. The bacterial species are Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus.

[0059] According to one embodiment herein, for the synthesis of the herbal spray composition for external haemorrhoids Matricaria recutita extract is mixed in a preset quantity with a Melilotus officinalis extract in a preset quantity and with a Crocus sativus extract in a preset quantity. The Matricaria recutita extract is mixed in a preset quantity of 8.4 ml. The Melilotus officinalis extract is mixed in a preset quantity of 1.4 ml. The Crocus sativus extract is mixed in a preset quantity of 0.2 ml.

[0060] According to one embodiment herein, the herbal spray composition for external haemorrhoids is an anti-inflammatory agent. The herbal spray composition for external haemorrhoids is an anti-crack agent. The herbal spray composition for external haemorrhoids relieves myalgia. The herbal spray composition for external hemorrhoids removes external inflammations through lymphatic vessels recovery. The herbal spray composition for external haemorrhoids prevents chronic wounds. The herbal extract mixture for external hemorrhoids comprises of small molecules. The small molecules of the herbal extract spray get absorbed and penetrate in skin/tissue layers. [0061] According to one embodiment herein, the herbal spray composition for external hemorrhoids is applied or administered twice a day on the area of the wound or hemorrhoids. The herbal composition for external hemorrhoids or spray is sprayed/ administered at a quantity of 2ml on the anus twice a day. The external hemorrhoids treatment spray is preferably sprayed/ administered once in the morning and once at night.

[0062] According to one embodiment herein, the colour of the herbal spray composition for external haemorrhoids is pale yellow to light brown. The density of the herbal composition for external haemorrhoids is 0.94-0.98 g/cm ³ . The pH of the herbal composition for external haemorrhoids is 3.02-4.67. The average volume of the herbal composition for external haemorrhoids is 55 ml. The herbal composition for external haemorrhoids is opaque. The viscosity of the herbal composition for external haemorrhoids is 5.63 m ² /s. The amount of the active constituent in the herbal composition for external haemorrhoids is 0.025% w/w.

[0063] According to one embodiment herein, the amount of flavonoids in the herbal spray composition for external haemorrhoids is 0.025% w/w.

[0064] According to one embodiment herein, the method for synthesizing the herbal mixture/spray composition for internal haemorrhoids comprises of the following steps. The Matricaria recutita flower, Allium porrum shoot and Apium graveolens stalk are cleaned to remove contaminants. The Matricaria recutita flower powder, Allium porrum shoot powder and Apium graveolens stalk powder are obtained after milling the Matricaria recutita flower, Allium porrum shoot and Apium graveolens stalk separately. The Matricaria recutita flower powder is mixed in a preset ratio with a preset ratio of a solvent. The Matricaria recutita flower powder and the solvent are mixed in a ratio of 1 :3. The solvent is water. The solution of Matricaria recutita flower powder is obtained. The Allium porrum shoot powder is mixed in a preset ratio with a preset ratio of a solvent. The Allium porrum shoot powder and the solvent are mixed in a ratio of 1 :3. The solvent is water. The solution of Allium porrum shoot powder is obtained. The Apium graveolens stalk powder is mixed in a preset ratio with a preset ratio of a solvent. The Apium graveolens stalk powder and the solvent are mixed in a ratio of 1 :3. The solvent is water. The solution of Apium graveolens stalk powder is obtained. The solutions of Matricaria recutita flower powder, Allium porrum shoot powder and Apium graveolens stalk powder are heated separately for 4 hours. The solutions of Matricaria recutita flower powder, Allium porrum shoot powder and Apium graveolens stalk powder are filtered after 4 hours. The filtrate is obtained. The filtrate comprises of herbal extracts of Matricaria recutita flower, Allium porrum shoot and Apium graveolens stalk. The herbal extracts of Matricaria recutita flower, Allium porrum shoot and Apium graveolens stalk extract are mixed to get a mixture. The honey is added to the mixture to obtain herbal extract mixture. The herbal extract mixture is blended in a mixer to attain consistency. The herbal extract mixture is filtered and pasteurized. The herbal extract mixture is stored in containers. The containers are polyethylene terephthalate (PET) containers.

[0065] According to one embodiment herein, for the synthesis of the herbal mixture/spray composition for internal haemorrhoids Matricaria recutita flower extract is mixed with Allium porrum shoot extract, Apium graveolens stalk extract and honey. The Matricaria recutita flower extract is mixed in preset quantity of 3.65 ml. T e Allium porrum shoot extract is mixed in preset quantity of 3.15 ml. The Apium graveolens stalk extract is mixed in preset quantity of 2.75 ml. The honey is mixed in preset quantity of 0.45 ml. [0066] According to one embodiment herein, the herbal mixture/spray composition for internal hemorrhoids is laxative agent. The herbal spray composition for internal haemorrhoids is tranquilizer agent. The herbal spray composition for internal haemorrhoids is anti-bleeding agent. The herbal spray composition for internal haemorrhoids is intestinal antiseptic. The herbal spray composition for internal haemorrhoids is internal wound tranquilizer. The herbal spray composition for internal haemorrhoids removes internal swelling. The herbal extract mixture for internal hemorrhoid comprises of small molecules. The small molecules of the herbal extract spray get absorbed and penetrate in skin/tissue layers. The herbal extract mixture for internal hemorrhoid makes defecation easy without difficulty. The herbal extract mixture for internal hemorrhoid regulates intestinal peristalsis and heals wounds.

[0067] According to one embodiment herein, the herbal mixture/spray composition for internal hemorrhoids is applied or administered twice a day on the area of the wound or hemorrhoids. The herbal composition for external hemorrhoids or spray is administered or injected in anus in a quantity of 2ml on the anus twice a day. Preferably the internal hemorrhoid treatment spray is sprayed/ administered once in the morning and once at night.

[0068] According to one embodiment herein, the colour of the herbal composition mixture/spray for internal haemorrhoids is cream. The density of the herbal composition for internal haemorrhoids is 0.99 g/cm ³ . The pH of the herbal composition for internal haemorrhoids is 2.89. The average volume of the herbal composition for internal haemorrhoids is 110 ml. The herbal composition for internal haemorrhoids is transparent. The viscosity of the herbal composition for internal haemorrhoids is 9.98 m ² /s. The amount of the active constituent in the herbal composition for internal haemorrhoids is 0.013% w/w.

[0069] According to one embodiment herein, the amount of flavonoids in the herbal composition for internal haemorrhoids is 0.013% w/w.

[0070] According to one embodiment herein, the method for synthesizing the anti-constipation topical oil for constipation comprises the following steps. The sesame seeds and castor seeds are cleaned to remove contaminants. The sesame seeds are crushed for extracting sesame seed shells and obtaining seed kernels. A dough is synthesized from the sesame seed kernel. The pressure is applied to the sesame seed kernel dough at a low temperature. The oil is extracted from the sesame seed kernel dough by cold pressing. The concentration of extracted oil from sesame seed kernel dough is 38-50% v/v. The castor seed shells are removed to obtain the castor seeds. The hydraulic pressure is applied on castor oil seeds in a low temperature for extracting castor oil. The castor oil is refined. The concentration of refined castor oil is 33% v/v. The sesame seed oil and the castor oil are mixed to obtain an oil mixture. The oil mixture is blended to attain uniform consistency. The oil mixture is filtered. The oil mixture is stored in containers. The containers are polyethylene terephthalate (PET) containers.

[0071] According to one embodiment herein, for the synthesis of the anti- constipation topical oil for constipation Sesamum indicum oil is mixed with the Ricinus communis oil. The Sesamum indicum oil is mixed in a preset quantity of 60% v/v. The Ricinus communis oil is mixed in a preset quantity of 40% v/v.

[0072] According to one embodiment herein, the anti-constipation topical oil for constipation is administered in a quantity of 2 ml. The anti-constipation topical oil is injected into anus by a syringe. Preferably the anti-constipation topical oil is administered in the morning and at midnight.

[0073] According to one embodiment herein, the anti-constipation topical oil is negative for the growth of plurality of bacterial species. The bacterial species are Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus.

[0074] According to one embodiment herein, the colour of the herbal composition for anti-constipation topical oil is cream. The density of the anti-constipation topical oil is 0.89 g/cm ³ . The pH of the anti-constipation topical oil is 4.46. The average weight of the anti-constipation topical oil is 25 ml. The viscosity of the anti-constipation topical oil is 2690 m ² /s. The amount of acidity of anti-constipation topical oil is 2.24.

[0075] According to one embodiment herein, the anti-constipation topical oil is laxative agent. The anti-constipation topical oil is healing agent. The anti-constipation topical oil is tranquilizer. The anti-constipation topical oil makes defecation smooth. The anti-constipation topical oil stops pressure on anus and rectum. The anti-constipation topical oil relieves pain and stops bleeding.

[0076] According to one embodiment herein, the integrated herbal composition for targeting haemorrhoids with plurality or combination of herbal compositions comprises of the following. A herbal spray composition for external haemorrhoids, a herbal mixture composition for internal haemorrhoids and an anti-constipation topical oil.

[0077] According to one embodiment herein, in the composition of herbal spray composition for external haemorrhoids comprises Matricaria recutita extract, Melilotus officinalis extract, and Crocus sativus extract. The Matricaria recutita extract is present in a preset quantity of 8.4 ml. The Melilotus officinalis extract is present in a preset quantity of 1.4 ml. The Crocus sativus extract is present in a preset quantity of 0.2 ml.

[0078] According to one embodiment herein, the herbal spray composition for external hemorrhoids is negative for the growth of plurality of bacterial species. The bacterial species are Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus.

[0079] According to one embodiment herein, the herbal spray composition for external hemorrhoids is anti- inflammatory agent. The herbal spray composition for external haemorrhoids is anti-crack agent. The herbal spray composition for external haemorrhoids relieves myalgia. The herbal spray composition for external haemorrhoids removes external inflammations through lymphatic vessels recovery. The herbal spray composition for external haemorrhoids prevents chronic wounds. The herbal extract mixture for external hemorrhoid comprises of small molecules. The small molecules of the herbal extract spray get absorbed and penetrate in skin/tissue layers.

[0080] According to one embodiment herein, the colour of the herbal composition for external haemorrhoids is pale yellow to light brown. The density of the herbal composition for external haemorrhoids is 0.94-0.98 g/cm ³ . The pH of the herbal composition for external haemorrhoids is 3.02-4.67. The average volume of the herbal composition for external haemorrhoids is 55 ml. The herbal composition for external haemorrhoids is opaque. The viscosity of the herbal composition for external haemorrhoids is 5.63 m ² /s. The amount of the active constituent in the herbal composition for external haemorrhoids is 0.025% w/w. [0081] According to one embodiment herein, the amount of flavonoids in the herbal composition for external haemorrhoids is 0.025% w/w.

[0082] According to one embodiment herein, the composition of herbal mixture/spray composition for internal haemorrhoids comprises Matricaria recutita flower extract, a Allium porrum shoot extract, a Apium graveolens stalk extract and honey. The Matricaria recutita flower extract is present in preset quantity of 3.65 ml. The, Allium porrum shoot extract is present in preset quantity of 3.15 ml. The, Apium graveolens stalk extract is present in preset quantity of 2.75 ml. The honey is present in a preset quantity of 0.45 ml.

[0083] According to one embodiment herein, the herbal mixture/spray composition for internal hemorrhoids is laxative agent. The herbal mixture/spray composition for internal haemorrhoids is tranquilizer agent. The herbal mixture/spray composition for internal haemorrhoids is anti-bleeding agent. The herbal mixture/spray composition for internal haemorrhoids is intestinal antiseptic. The herbal mixture/spray composition for internal haemorrhoids is internal wound tranquilizer. The herbal mixture/spray composition for internal haemorrhoids removes internal swelling. The herbal extract mixture/spray for internal hemorrhoid comprises of small molecules. The small molecules of the herbal extract spray get absorbed and penetrate in skin/tissue layers. The herbal extract mixture/spray for internal hemorrhoid makes defecation easy without difficulty. The herbal extract mixture for internal hemorrhoid regulates intestinal peristalsis and heals wounds.

[0084] According to one embodiment herein, the colour of the herbal mixture/spray composition for external haemorrhoids is cream. The density of the herbal composition for internal haemorrhoids is 0.99 g/cm ³ . The pH of the herbal composition for internal haemorrhoids is 2.89. The average volume of the herbal composition for internal haemorrhoids is 110 ml. The herbal composition for external haemorrhoids is transparent. The viscosity of the herbal composition for internal haemorrhoids is 9.98 m ² /s. The amount of the active constituent in the herbal composition for internal haemorrhoids is 0.013% w/w.

[0085] According to one embodiment herein, the amount of flavonoids in the herbal mixture/spray composition for internal haemorrhoids is 0.013% w/w.

[0086] According to one embodiment herein, the anti-constipation topical oil for constipation comprises Sesamum indicum oil, Ricinus communis oil. The Sesamum indicum oil is present in preset quantity of 60% v/v. The Ricinus communis oil is present in preset quantity of 40% v/v.

[0087] According to one embodiment herein, the anti-constipation topical oil is negative for the growth of plurality of bacterial species. The bacterial species are Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus.

[0088] According to one embodiment herein, the colour of the herbal composition for anti-constipation topical oil is cream. The density of the anti-constipation topical oil is 0.89 g/cm ³ . The pH of the anti-constipation topical oil is 4.46. The average weight of the anti-constipation topical oil is 25 ml. The viscosity of the anti-constipation topical oil is 2690 m ² /s. The amount of acidity of anti-constipation topical oil is 2.24.

[0089] According to one embodiment herein, the anti-constipation topical oil is a laxative agent. The anti-constipation topical oil is healing agent. The anti-constipation topical oil is tranquilizer. The anti-constipation topical oil makes defecation smooth. The anti-constipation topical oil stops pressure on anus and rectum. The anti-constipation topical oil relieves pain and stops bleeding. [0090] According to one embodiment herein, there are three medicines for the treatment of external hemorrhoids, internal hemorrhoids and constipation. 1) a herbal spray for external hemorrhoids. Administering the external spray twice a day resolves the clots and stops bleeding.2) a herbal mixture for internal hemorrhoids. Injecting (2 ml) of the herbal mixture into the anus stops bleeding that is caused by constipation, heals internal swelling, eases the act of defecation and recovers the injuries inside the rectum.3) topical oil for constipation. Injecting (3ml) of this oil into the anus soften the skin and helps the recovery of cracks inside the anus. By soothing rectum, the oil relieves the pressure on the rectum and anus.

EXPERIMENT- 1 Herbal Composition For External Hemorrhoid;

[0091] According to one embodiment herein, Table 1 below illustrates the components used for the synthesis of herbal composition for external hemorrhoid:

[0092] FIG. 1 illustrates a flow chart indicating a method for synthesizing herbal spray for external hemorrhoids, according to one embodiment herein. The Matricaria recutita flowers and Melilotus officinalis flowers are cleaned to remove contaminants (101). Matricaria recutita flowers and Melilotus officinalis flowers are milled separately and Crocus sativus stigma are grinded separately (102). One part of the Matricaria recutita flower powder and Melilotus officinalis flower powder are mixed separately with three part of hydrochloric solvent (30% v/v) (103). One part of the Matricaria recutita flower powder and Melilotus officinalis flower powder are mixed separately with three part of hydrochloric solvent (30% v/v) to obtain separate mixtures (104). The Matricaria recutita flower powder mixture and Melilotus officinalis flower powder mixture are incubated in the steam distillation apparatus for four days (105). The extracts of Matricaria recutita and Melilotus officinalis are obtained and each extract to is mixed get a mixture (106). The Crocus sativus stigma extract is added to the mixture of Matricaria recutita and Melilotus officinalis extracts to obtain herbal extract mixture (107). The herbal extract mixture is blended in a mixer to attain consistency; linseed enamel and thickened grape juice is added while blending (108). The herbal extract mixture is filtered and pasteurized (109). The herbal extract mixture is stored in 50 ml PET containers (110).

[0093] FIG.2 illustrates an image indicating the anti-microbial analysis report of herbal spray for external hemorrhoids, according to one embodiment herein. The results illustrates that the herbal spray for external hemorrhoids is negative for Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus.

[0094] According to one embodiment herein, the Matricaria recutita

(Chamoline) flower and Melilotus officinalis (Yellow sweet clover) flower were cleaned to remove all the contaminants. The Matricaria recutita (Chamoline) flower and Melilotus officinalis (Yellow sweet clover) flower were milled in a Mash mixer and the Crocus sativus (Saffron) stigma were powdered. The herbal extracts from Matricaria recutita flower and Melilotus officinalis flower were extracted through steam distillation or percolation. For the steam distillation or percolation one part of plants powder was mixed with three parts of hydrochloric solvent (30% v/v) separately. The plant powder and the hydrochloric solvent were incubated in the steam distillation apparatus for four days. The herbal extracts from the flowers of Matricaria recutita and Melilotus officinalis were obtained and mixed. The Crocus sativus stigma's herbal extract was added to the mixture of flower extracts of Matricaria recutita and Melilotus officinalis to obtain an herbal extract mixture. The herbal extract mixture was blended in a mixer till the extract molecules become completely consistence and to obtain the extract mixture. The linseed enamel and thickened grapes juice was added to the mixture while still mixing. Then the herbal extract mixture was filtered and pasteurized the in order to control bacterial and fungal infections. The sampling was done and after confirmation, 50 ml polyethylene terephthalate (PET) containers were filled with this mixture.

[0095] Table 2 below illustrates the active constituents of the herbal composition for external hemorrhoids:

SI Constituents' Form of Percent of Amount of Role of

No. names constituents constituents constituents constituents used in (w/v or w/w) used in 10 ml in

formulation formulation formulation

1. Matricaria Liquid 84% 8.4 ml active

extract

2. Crocus staivus Liquid 2% active

extract 0.2 ml

3. Melilotus Liquid 14% 1.4 ml active

officinalis

extract 4. excipients

[0096] For the production of 50000mg of herbal composition for external hemorrhoids 42000mg of Matricaria recutita extract, lOOOmg Crocus sativus extract and 7000mg Melilotus officinalis extract are mixed. The herbal extracts in the spray relieves myalgia, removes external inflammations through lymphatic vessels recovery, and prevents the chronic wounds. The herbal extracts also act as an anti-inflammation agent and anti crack spray. The herbal composition for external haemorrhoid is kept in cool, dry place. The herbal composition for external haemorrhoid is kept away from sun light and under 30°C.

[0097] According to one embodiment herein, the herbal composition for external hemorrhoids or spray is applied or administered twice a day on the area of the wound or hemorrhoids. The area of wound must become wet after the application of the extract mixture. The extract mixture comprises of small molecules. The small molecules of the herbal extract spray get absorbed and penetrates in skin/tissue layers quickly. The camazolene in the Matricaria recutita and the vitamins that exist in the plants recover the wounds. This spray for external hemorrhoids is used at home, clinics, medical centers, and private centers easily. Further spray for external hemorrhoids is administered to any patient irrespective of the age of patients. The spray doesn't have any side effects. The plant resources in Iran are abundant. Hence the external spray for hemorrhoids is very economic.

[0098] According to one embodiment herein, the herbal composition for external hemorrhoids or spray is sprayed/ administered at a quantity of 2ml on the anus twice a day. Preferably the external hemorrhoid treatment spray is sprayed/ administered once in the morning and once at night. [0099] According to one embodiment herein, for the thin layer chromatographic analysis of the Crocus sativus stigma's extract, the Crocus sativus stigma's are crushed with drops of distilled water. After 3 minutes 1 ml methanol is added to obtain a mixture. The mixture is incubated in dark for 20 minutes. After incubation the mixture is filtered to obtain a filtrate. 10 μΐ of the filtrate is used for the TLC (thin Layer Chromatography) .

[00100] After the analysis of the Crocus sativus extract it was found that the organic substances are present in a quantity of 0.56% w/w, total ash is present in a quantity of 7.5% w/w, insoluble ash in hydrochloric acid is present in a quantity of 0.83% w/w, humidity is present in a quantity of 4.8%w/w. Crocus sativus is used as an aromatic substance and as a flavor. Fresh Crocus sativus is used as sedative and antispasmodic.

[00101] According to one embodiment herein, for the thin layer chromatographic analysis of the Melilotus officinalis (Yellow sweet clover) flower extract; the Melilotus officinalis flowers are crushed with drops of distilled water. After 3 minutes 1 ml methanol is added to obtain a mixture. The mixture is incubated in dark for 20 minutes. After incubation the mixture is filtered to obtain a filtrate. 10 μΐ of the filtrate is used for the TLC (thin Layer Chromatography).

[00102] After the analysis of the Melilotus officinalis extract it was found that the organic substances are present in a quantity of 1.2 %w/w, Total ash is present in a quantity of 5.68 %w/w, Insoluble ash in hydrochloric acid is present in a quantity of 1.03%w/w, Humidity 3.8 %.

[00103] Table 3 below illustrates the physicochemical properties of the herbal composition for external hemorrhoids: Row Physical & Iranian Acceptable Examination chemical sample range reference

examinations

1 - Color Light brown Light brown internal

2- Smell special special internal

3- Density(g/cc) 0.94 (0.8-1.2) internal

4- pH 4.67 (3-6) internal

5- Average volume 50 ml (46-56)ml USP34

6- Transparency opaque opaque USP34

7- Viscosity(cp) 5.63 (3-15) USP34

8- Amount of 0.025% (0.02-0.03)% BP2012

active

constituent

9- identification match The sample's Rf Iran

is the same as pharmacopoeia standard Rf

[00104] FIG. 3 illustrates an image indicating the analysis report of herbal spray for external hemorrhoids, according to one embodiment herein. The density of herbal spray for external hemorrhoids is 0.98 g/cm ³ . The pH of herbal spray for external hemorrhoids is 3.02. The odor of herbal spray for external hemorrhoids is distinct odor. The color of herbal spray for external hemorrhoids is cream to pale yellow.

[00105] According to one embodiment herein, for the analysis of the flavonoids content in the herbal composition for external hemorrhoids or spray 10 ml of the sample herbal composition is poured in the 100 ml round bottom flask. 20ml acetone and 7ml hydrochloric acid 25%) v/v are added to 1 ml hexa methyl tetra amine 0.5% v/v to obtain a mixture. The hexa methyl tetra amine was obtained by dissolving 0.5 g hexa methyl tetra amine in water and pouring it in 100ml volumetric flask. The mixture is incubated in water bath. Then the mixture is filtered by cotton in a 100ml volumetric flask to obtain a filtrate. The cotton plug is applied in the round bottom flask and the filtrate is boiled with 20ml acetone twice, after cooling the filtrate, it is added to a solvent.

[00106] The volume of the sample is made up to 100ml with acetone to obtain a mixture. 20ml of the mixture is taken and put it in a decanter. 20ml of distilled water is added to it. Extraction is done once with 15ml ethyl acetate and three times with 10ml ethyl acetate. The solvent is embrocated with 50ml distilled water two times and then volume it in a 50ml volumetric flask with ethyl acetate.

[00107] 10ml of the sample is poured in two 25ml volumetric flask. In one flask add 1ml aluminum chloride (aluminium chloride is obtained by dissolving 2g aluminum chloride in methanol acetic acid 5% and the volume is made up in 100ml volumetric flask). The volume of the volumetric flasks are made up with methanol acetic acid 5%. Incubating the volumetric flask for 20minutes in order to have a complete color complex. Reading the sample absorption in 425nm wavelength and calculating the total flavonoids from the below formula.

V=the volume of used sample

A=the absorption of tested sample

The amount of sample active constituent:

V=10ml

A=0.201 sampl imim percent —™— =0.025%

[00108] According to one embodiment herein, the flavonoids content in the herbal composition for external hemorrhoids or spray is 0.025% w/w.

EXPERIMENT-2 Herbal Composition For Internal Hemorrhoid;

[00109] According to one embodiment herein, Table 4 below illustrates the components used for the synthesis of herbal composition for internal hemorrhoid:

[00110] According to one embodiment herein, the internal hemorrhoids herbal treatment composition comprises of extracts from Matricaria recutita (Chamoline) flower, Allium porrum (Leek) shoot and Apium graveolens (Celery) stalk. The herbal extracts from the aforementioned plants is mixed with honey.

[00111] FIG.4 illustrates a flow chart indicating a method for synthesizing herbal composition for internal hemorrhoids, according to one embodiment herein. The Matricaria recutita flowers, Allium porrum shoots and Apium graveolens stalks are cleaned to remove contaminants (401). The Matricaria recutita flowers, Allium porrum shoots and Apium graveolens stalks are milled separately to obtain powder (402). One part of the Matricaria recutita flower powder, Allium porrum shoot powder and Apium graveolens stalk powder is mixed separately with three part of water as solvent to get separate solutions (403). The Matricaria recutita flowers powder, Allium porrum shoot powder and Apium graveolens stalk powder solutions are heated separately with three part of water for 4 hours (404). The solutions after 4 hours are filtered to obtaining filtrate comprising herbal extracts of Matricaria recutita flower, Allium porrum shoot and Apium graveolens stalk (405). The herbal extracts of Matricaria recutita flower, Allium porrum shoot and Apium graveolens stalk are mixed to get a mixture (406). Honey is added to the mixture to obtain herbal extract mixture (407). The herbal extract mixture is blended in a mixer to attain consistency (408). The herbal extract mixture is filtered and pasteurized (409). The herbal extract mixture in is stored 110 ml PET containers (410).

[00112] According to one embodiment herein, Matricaria recutita (Chamoline) flower, Allium porrum (Leek) shoot and Apium graveolens (Celery) stalk were cleaned to remove all the contaminants. The Matricaria recutita (Chamoline) flower, Allium porrum (Leek) shoot and Apium graveolens (Celery) stalk were milled in a Mash mixer to obtain a grinded powder. The herbal extracts from Matricaria recutita (Chamoline) flower, Allium porrum (Leek) shoot and Apium graveolens (Celery) stalk were extracted through steam distillation or percolation. One part of Matricaria recutita (Chamoline) flower powder, Allium porrum (Leek) shoot powder and Apium graveolens (Celery) stalk powder were mixed separately with 4 parts of water as a solvent were mixed. The plant powders and water were heated and cooked for 4 hours. After 4 hours the filtration is done to obtain filtrate comprising herbal extracts of Matricaria recutita (Chamoline) flower, Allium porrum (Leek) shoot and Apium graveolens (Celery) stalk. In order to control bacterial and fungal infections the herbal extract was pasteurized. The herbal extracts of Matricaria recutita (Chamoline) flower, Allium porrum (Leek) shoot and Apium graveolens (Celery) stalk were mixed till the consistency was achieved. Honey is added to the herbal extract mixture and was mixed in a mixer till a uniform consistency was achieved. After mixing the mixture is filtered. Then the herbal extract mixture was filtered and pasteurized the in order to control bacterial and fungal infections. The sampling was done and after confirmation, 110 ml polyethylene terephthalate (PET) containers were filled with this mixture.

[00113] Table 5 below illustrates the active constituents of the herbal composition for internal hemorrhoids:

[00114] FIG.5 illustrates an image indicating the analysis report of composition for internal hemorrhoids, according to one embodiment herein. The density of the herbal composition for internal hemorrhoids is 0.99 g/cm ³ . The pH of the herbal composition for internal hemorrhoids is 2.89. The odor of the herbal composition for internal hemorrhoids distinct characteristic odor. The color of the herbal composition for internal hemorrhoids is colorless to plae yellow.

[00115] According to one embodiment herein, for the production of 11 OOOOmg of herbal extract mixture for internal hemorrhoid 40000mg Matricaria recutita extract, 35000mg of Allium porrum extract, 3 OOOOmg Apium graveolens extract and 5000mg honey are mixed. This herbal extract mixture for internal hemorrhoid is laxative agent, tranquilizer, anti bleeding agent, intestinal antiseptic, and internal wound tranquilizer and removes internal swelling. This herbal extract mixture for internal hemorrhoid makes defecation easy without difficulty and this result in patients' recovery. The herbal composition for external haemorrhoid is kept away from sun light and under 30°C.

[00116] According to one embodiment herein, the herbal extract mixture for internal hemorrhoid is administered in a quantity of 2 ml. The herbal extract mixture for internal hemorrhoid is administered by injecting in the Anus every 12 hours. Preferably the herbal spray for internal hemorrhoids is administered once in the morning and once in night. The herbal extract mixture for internal hemorrhoid comprises of small molecules. The small molecules of the herbal extract spray get absorbed and penetrate in skin/tissue layers quickly. The camazolene in the matricaria and the other vitamins that exist in the plants recover the wounds and swellings of anus and makes defecation easy by regulating the intestinal peristalsis. This spray for internal hemorrhoids is used at home, clinics, medical centers, and private centers easily. Further spray for internal hemorrhoids is administered to any patient irrespective of the age of patients. The spray doesn't have any side effects. The plant resources in Iran are abundant. Hence the external spray for hemorrhoids is very economic.

[00117] According to one embodiment herein, the herbal extracts of Matricaria recutita (Chamoline) flower, Allium porrum (Leek) shoot and Apium graveolens (Celery) stalk are subjected for the thin layer chromatographic (TLC) analysis. The 11 gram powder of each Matricaria recutita (Chamoline) flower, Allium porrum (Leek) shoot and Apium graveolens (Celery) stalk is taken in separate test tube. 2.5 ml of a mixture comprising 0.25 g dimethyl amino benz aldehyde, 5 ml phosphoric acid 85%, 45 ml acetic acid 30% and 45 ml distilled water is added to the test tubes comprising 11 g powder of the each plant. The test tubes are heated for 5 minutes on a water bath. After cooling the test tubes at room temperature 5 ml of petroleum ether is added to each test tube and shaken for 1-2 minutes. A blue green color is developed. 10 μΐ of the content from each test tube is used for the TLC (thin Layer Chromatography).

[00118] After the analysis of the Matricaria recutita (Chamoline) flower extract it was found that the organic substances are present in a quantity of 1.1 % w/w, the total ash is present in a quantity of 7.89%) w/w, insoluble ash in hydrochloric acid is present in a quantity of 1.12 % w/w, the soluble extracts in water are present in a quantity of 5.3% w/w and humidity 4.8%.

[00119] After the analysis of the Allium porrum (Leek) shoot extract it was found that the Allium porrum has an essence which consists of sulfide compounds. The leaves have enzymes such as maltase, isomaltase, invertase, and emulsin. There are plurality of carbohydrate in the roots, specifically arabinose and galactose.

[00120] After the analysis of the Apium graveolens (Celery) stalk extract it was found that the organic substances are present in a quantity of 0.92% w/w, the total ash is present in a quantity of 6.73% w/w, the insoluble ash in hydrochloric acid is present in a quantity of 1.04% w/w, the soluble extract in water is present in a quantity of 6.73% w/w and humidity 4.23%. [00121] Table 6 below illustrates the physicochemical properties of the herbal composition for internal hemorrhoids:

[00122] According to one embodiment herein, the high percentage of the organic molecules in the celery seeds/stalk extract make them antispasmodic. The presence of n-butylphthalide and methylphthalide make the celery seeds/stalk extract sedative. The apiol in the celery seeds/stalk extract makes it diuretic and some of the coumarins in the plant are sedative. The fruits (seeds) of celery are dark-brown, oblong shaped with white vertical ridges, and they are strongly aromatic. The seeds of celery have impurities in a quantity of 1%) w/w, total ash in a quantity of 10% w/w, insoluble ash in hydrochloric acid in a quantity of 2%w/w and soluble extract in water in a quantity of 12% w/w. [00123] Matricaria recutita (Chamoline) flower comprises of a group of lipophilic substances which are anti-inflammatory. The major constituents of Matricaria recutita (Chamoline) flower extract are matricine, bisabolol and its oxides which act against inflammation. This inflammatory activity is attributed to antioxidants' effects, similar to leukotrienes synthesis. The Matricaria recutita (Chamoline) flower extract comprises of impurities 25% w/w, sulfated ash in a quantity of 13%, total ash in a quantity of 9%w/w and soluble ash in acid in a quantity of 7.5% w/w.

[00124] According to one embodiment herein, for the analysis of the flavonoids content in the herbal composition for internal hemorrhoids, 10 ml of the sample herbal composition is poured in the 100 ml round bottom flask. Add 20ml acetone and 7ml hydrochloric acid 25%v/v are added to 1 ml hexa methyl tetra amine 0.5% v/v in the flak to obtain a mixture. The hexa methyl tetra amine was obtained by dissolving 0.5 g hexa methyl tetra amine in water and pouring it in 100ml volumetric flask. The mixture is incubated in water bath for 30 minutes. Then the mixture is filtered by cotton in a 100ml volumetric flask to obtain a filtrate. The cotton plug is applied in the round bottom flask and the filtrate is boiled with 20ml acetone twice, after cooling the filtrate, it is added to a solvent.

[00125] The volume of the sample is made up to 100ml with acetone to obtain a mixture. 20ml of the mixture is taken and put it in a decanter. 20ml of distilled water is added to it. Extraction is done once with 15ml ethyl acetate and three times with 10ml ethyl acetate. The solvent is embrocated with 50ml distilled water two times and then volume it in a 50ml volumetric flask with ethyl acetate.

[00126] 10ml of the sample is poured in two 25ml volumetric flask. In one flask add 1ml aluminum chloride (aluminium chloride is obtained by dissolving 2g aluminum chloride in methanol acetic acid 5% and the volume is made up in 100ml volumetric flask). The volume of the volumetric flasks are made up with methanol acetic acid 5%. Incubating the volumetric flask for 20minutes in order to have a complete color complex. Reading the sample absorption in 425nm wavelength and calculating the total flavonoids from the below formula.

A * 1.25

sample · mmds percent -··■ -™

¥

V=the volume of used sample

A=the absorption of tested sample

The amount of sample active constituent:

V=10ml

A=0.106

iSample flavonoids percent ~- ^-:^^-^=Q Q ^%

[00127] According to one embodiment herein, the flavonoids content in the herbal composition for internal hemorrhoids or spray is 0.013% w/w.

EXPERIMENT-3 Topical Oil for Constipation;

[00128] According to one embodiment herein, Table 7 below illustrates the components used for the synthesis of topical oil for constipation:

[00129] According to one embodiment herein, for the synthesis of anti- constipation oil mixture, the sesame seeds are cleaned. After cleaning, the sesame seeds are crushed for extracting the shells. The seed kernals are obtained after removing the seed shells. The seed kernels are turned into dough. The seed kernel dough is put under pressure in low temperature condition. This process is called cold pressing and extracts about 38-50% oil from sesame seeds. For extracting the castor oil the castor seed shells are removed. The seeds obtained after removing shells are kept under hydraulic pressure in low temperature condition. After refining 33% castor oil obtained.

[00130] The sesame seed oil and the castor oil are mixed. The oil mixture is blended in a mixer till the extract molecules become completely consistence and to obtain the extract mixture. The repository is filled with the oil mixture. The herbal extract mixture is stored in containers. 50 ml Polyethylene terephthalate containers are filled with the oil mixture. The oil mixture is laxative, healing agent, tranquilizer and it makes stool passing without difficulty and stops pressure on the anus and rectum so there is no pain and bleeding.

[00131] According to one embodiment herein, the oil mixture for constipation is preferably administered in a quantity of 2 ml in the anus by a syringe twice a day. Preferably the oil is administered in the morning and at midnight.

[00132] FIG.6 illustrates a flow chart indicating a method for synthesizing anti-constipation topical oil, according to one embodiment herein. The sesame seeds and castor seeds are cleaned to remove contaminants (601). The sesame seeds are crushed for extracting the seed shells and obtaining the seed kernel (602). A dough is made from the seed kernel and the kernel dough is put under pressure at a low temperature (603). 38-50% oil is extracted from the sesame kernel dough by cold pressing (604). The castor oil seed shells are removed, and the castor oil seeds are obtained (605). The hydraulic pressure is applied on castor oil seeds in a low temperature to extract castor oil (606). The extracted castor oil to is refined obtain 33% refined castor oil (607). The sesame seed oil and castor oil is mixed to obtain an oil mixture (608). The oil mixture is blended in a mixer to attain consistency (609). The oil mixture is filtered (610). The oil mixture is stored in 50 ml PET containers (611)

[00133] According to one embodiment herein, the anti-constipation topical oil comprises of mixture of Sesamum indicum (Sesame) oil and Ricinus communis (Castor oil plant) oil. To make 50000mg of this topical anti constipation oil mixture 30000mg Sesamum indicum (60%v/v) and 20000mg castor oil 40% v/v oil is mixed. The oil must be kept/stored in a cool and dry place, under 30°C and away from sun light.

[00134] Table 8 below illustrates the active constituents of the topical oil for constipation:

EXPERIMENT-3.1 Different Qualitative and Quantitative Analysis of Castor Oil;

[00135] According to one embodiment herein, during the preliminary identification of castor oil, the castor oil changes into an ointment like substance at a temperature of 60°C. Adding 2.00 ml petroleum ether to 5ml castor oil makes a clear mixture that will be opaque by adding more petroleum ether to it. Moreover by mixing 5g of this substance to 5ml HNO3 and shaking with 5ml resorcinol you will have red to blue purple color. Heating 3g of this substance with l .Og potassium hydroxide will make a smell like octyl alcohol's smell. For obtaining the sebacic acid crystals the oil with potassium hydroxide mixture, 30 ml water is added to the mixture. A large amount of magnesium oxide is added to the mixture. The mixture is refined and acidized with hydrochloric acid. The sebacic acid crystals settled. Only a little of this oil dissolves in hexane and it makes a clear liquid with the same amount of ethanol.

[00136] According to one embodiment herein, for the acidity analysis of the castor oil weight 5g of the oil and add 25g of a mixture that includes (same amount of) ethanol (96%), and ether which is neutralized by KOH and 0.5ml of phenolphthalein as an identifier. When the substance became completely neutralized, the titration is done with KOH. During titration the flask is shaken continuously till a pink color is obtained at least for 15 seconds. Acidity is calculated through 5.610v/w. V stands for the volume of needed potassium hydroxide according to Ml and W stands for the weight of tested substance according to g. When the oil is old the acidity is higher and higher the acidity at the beginning of preparing oil is the sign of inappropriate extraction, spoiled seed and bad preservation. The acidity of the oil is 2.0

[00137] According to one embodiment herein, light absorption property or wavelength of the castor oil in the 1% solution W/V in ethanol (96%) in 268-270nm is 1.0.

[00138] According to one embodiment herein, optical rotation property of castor oil is + 3.5° to + 6.0°.

[00139] According to one embodiment herein, primary oxidation value or peroxide value of castor oil up to 5.0.

[00140] According to one embodiment herein, refractive index of castor oil is 1.477 to 1.481. [00141] According to one embodiment herein, relative density of the castor oil is 0.952 to 0.965.

[00142] According to one embodiment herein, the sesame seeds are small and about 2-4 mm wide, ovate and slightly flattened. The weight of sesame seeds is between 20 and 40 mg. The sesame seeds are yellow colored, sweet and oily. The sesame oil is extracted by putting sesame seeds under pressure.

EXPERIMENT-3.2 Different Qualitative and Quantitative Analysis of Sesame Oil;

[00143] According to one embodiment herein, for the sesame oil identification the existence of sesamol and sesamolin in non-triglyceride part of sesame oil is identified easily through Baudouin test and Villavecchia test. This test is used to identify sesame oil: mix 10ml sesame oil with 4.5ml acetic anhydride, and 0.5ml of formaldehyde 0.35% solvent in acetic anhydride for 1 minute. The mixture obtained is refined through a filter paper saturated by acetic anhydride. Add 0.2 ml sulfuric acid is added to the mixture. If the color is blue green, the presence of sesame oil is confirmed.

[00144] According to one embodiment herein, the acidity refers to the amount of organic acids in fats which is less than 0.6 for sesame oil.

[00145] According to one embodiment herein, the Saponification value represents the number of milligrams of potassium hydroxide required to saponify lg of fat under conditions specified. The saponification value of sesame oil is 188-195.

[00146] According to one embodiment herein, the iodine value refers to the amount of unsaturation in fatty acids. The iodine value for sesame oil is 104-116. [00147] According to one embodiment herein, the peroxide value refers to the amount of peroxide oxygen per 1 kilogram of fat or oil, which is a good method for evaluating the degree of oil corruption. The peroxide value for sesame oil is 1-3.

[00148] According to one embodiment herein, physical characteristicsof sesame oil is pale yellow, liquid and almost without smell and with mild flavor. It will change into solid in -4°C and weight 0.921-0.924 in 15°C. The refractive index of sesame oil is 1.473-1.476.

[00149] According to one embodiment herein, for the purity examination of sesame oil thin layer chromatography (TCL) is used, in which the stationary phase is silica gel G F 254 and the mobile phase is acetic acid 99%.

[00150] According to one embodiment herein, the quality analysis of sesame seeds discloses that the total ash is present is in a quantity of 5.5%w/w, sulfated ash is present in a quantity of 3.6% w/w and soluble ash in water is present in a quantity of 0.86% w/w. [00151] According to one embodiment herein, the sesame oil is used as laxative, skin healer and softener. Sesame oil decreases blood sugar. Sesame oil is used as a solvent and an oil base for pharmaceutical industry, for healthcare and cosmetics industry.40- 60 gram sesame oil is used as laxative.

[00152] Table 9 below illustrates the physicochemical properties of the topical oil for constipation:

Row Physical & Iranian Acceptable Examination

chemical sample range reference

examinations 1. Color cream cream internal

2. Smell special special internal

3. Density(g/cc) 0.89 (0.7-1.1) internal

4. pH 4.46 (3-6) internal

5. Average weight 25 ml (23-27)ml USP34

6. Viscosity(cp) 2690 (2000-4000) USP34

7. Amount of 2.24 (1.84-2.64) Iran

acidity pharmacopoeia

and BP2012

8. identification match The sample's Rf Iran

is the same as pharmacopoeia standard Rf

[00153] FIG.7 illustrates an image indicating the anti-microbial analysis report of anti-constipation topical oil, according to one embodiment herein. The results illustrates that the anti-constipation topical oil is negative for Escherichia coli, Salmonella sp, Pseudomonas aeroginosa, and Staphylococcus aureus.

[00154] According to one embodiment herein, for the acidity determination of the topical oil for constipation 5g of the oil mixture is taken and 25g of a mixture that includes (same amount of) ethanol (96%), and ether which is neutralized by potassium hydroxide and 0.5ml of phenolphthalein as an identifier) is added. When the mixture becomes completely neutralized, titration is done against potassium hydroxide. The flask is shaken continuously till the pink color is consistent at least for 15 seconds.

Acidity is calculated through b.&l ^™

V=the volume of used potassium hydroxide W= weight of substance in g

Acidity= S.61™ =2.24

¾v

V= 2 ml

W=5g

[00155] It is to be understood that the phraseology or terminology employed herein is for the purpose of description and not of limitation. Therefore, while the embodiments herein have been described in terms of preferred embodiments, those skilled in the art will recognize that the embodiments herein can be practiced with modification within the spirit and scope of the appended claims.

[00156] Although the embodiments herein are described with various specific embodiments, it will be obvious for a person skilled in the art to practice the invention with modifications. However, all such modifications are deemed to be within the scope of the claims.

[00157] It is also to be understood that the following claims are intended to cover all of the generic and specific features of the embodiments described herein and all the statements of the scope of the embodiments which as a matter of language might be said to fall there between.