Title:
ANTI-HSV ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2011/038933
Kind Code:
A3
Abstract:
The invention relates to an anti-HSV antibody as defined in the claims, a pharmaceutical composition comprising of an effective amount of the said antibody, an expression vector comprising of a nucleotide sequence which encodes the said antibody, a host cell comprising of the said nucleotide sequence, a hybridoma cell capable of producing the said antibody and the use of the said antibody as a drug, in particular to use for the manufacture of a drug for the prophylactical or therapeutical treatment of HSV-associated diseases in a subject; as defined in the claims.
Inventors:
ROGGENDORF MICHAEL (DE)
EIS-HUEBINGER ANNA-MARIA (DE)
KRAUSS JUERGEN (DE)
SCHNEWEIS KARL EDUARD (DE)
ARNDT MICHAELA (DE)
KRAWCZYK ADALBERT (DE)
EXNER EVELYN (DE)
DAEUMER MARTIN (DE)
EIS-HUEBINGER ANNA-MARIA (DE)
KRAUSS JUERGEN (DE)
SCHNEWEIS KARL EDUARD (DE)
ARNDT MICHAELA (DE)
KRAWCZYK ADALBERT (DE)
EXNER EVELYN (DE)
DAEUMER MARTIN (DE)
Application Number:
PCT/EP2010/006020
Publication Date:
June 30, 2011
Filing Date:
October 01, 2010
Export Citation:
Assignee:
UNIV DUISBURG ESSEN (DE)
UNIV BONN (DE)
ROGGENDORF MICHAEL (DE)
EIS-HUEBINGER ANNA-MARIA (DE)
KRAUSS JUERGEN (DE)
SCHNEWEIS KARL EDUARD (DE)
ARNDT MICHAELA (DE)
KRAWCZYK ADALBERT (DE)
EXNER EVELYN (DE)
DAEUMER MARTIN (DE)
UNIV BONN (DE)
ROGGENDORF MICHAEL (DE)
EIS-HUEBINGER ANNA-MARIA (DE)
KRAUSS JUERGEN (DE)
SCHNEWEIS KARL EDUARD (DE)
ARNDT MICHAELA (DE)
KRAWCZYK ADALBERT (DE)
EXNER EVELYN (DE)
DAEUMER MARTIN (DE)
International Classes:
C07K16/08; A61P31/22; C07K14/035
Foreign References:
| US20040058414A1 | 2004-03-25 |
Other References:
NAVARRO D ET AL: "Domains of herpes simplex virus I glycoprotein B that function in virus penetration, cell-to-cell spread, and cell fusion", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 186, no. 1, 1 January 1992 (1992-01-01), pages 99 - 112, XP023049309, ISSN: 0042-6822, [retrieved on 19920101]
ROLLER D G ET AL: "Structure-function analysis of herpes simplex virus glycoprotein B with fusion-from-without activity", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 382, no. 2, 20 December 2008 (2008-12-20), pages 207 - 216, XP025994150, ISSN: 0042-6822, [retrieved on 20081023]
KOUSOULAS K G ET AL: "Antibody-resistant mutations in cross-reactive and type-specific epitopes of herpes simplex virus 1 glycoprotein B map in separate domains", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 166, no. 2, 1 October 1988 (1988-10-01), pages 423 - 431, XP023049902, ISSN: 0042-6822, [retrieved on 19881001]
BYSTRICKÁ M ET AL: "Monoclonal antibodies to the distinct antigenic sites on glycoproteins C and B and their protective abilities in herpes simplex virus infection", ACTA VIROLOGICA, ACADEMIA PRAGUE, PRAGUE, CS, vol. 41, no. 1, 1 February 1997 (1997-02-01), pages 5 - 12, XP009130340, ISSN: 0001-723X
KUMEL G ET AL: "PASSIVE IMMUNE PROTECTION BY HERPES SIMPLEX VIRUS-SPECIFIC MONOCLONAL ANTIBODIES AND MONOCLONAL ANTIBODY-RESISTANT MUTANTS ALTERED IN PATHOGENICITY", JOURNAL OF VIROLOGY, vol. 56, no. 3, 1985, pages 930 - 937, XP002571807, ISSN: 0022-538X
BENDER FLORENT C ET AL: "Antigenic and mutational analyses of herpes simplex virus glycoprotein B reveal four functional regions", JOURNAL OF VIROLOGY, vol. 81, no. 8, April 2007 (2007-04-01), pages 3827 - 3841, XP002571808, ISSN: 0022-538X
EIS-HÜBINGER A M ET AL: "Anti-glycoprotein B monoclonal antibody protects T cell-depleted mice against herpes simplex virus infection by inhibition of virus replication at the inoculated mucous membranes.", THE JOURNAL OF GENERAL VIROLOGY MAR 1993, vol. 74 ( Pt 3), March 1993 (1993-03-01), pages 379 - 385, XP002571809, ISSN: 0022-1317
EIS-HUEBINGER A M ET AL: "DIFFERENT MECHANISMS OF PROTECTION BY MONOCLONAL AND POLYCLONAL ANTIBODIES DURING THE COURSE OF HERPES SIMPLEX VIRUS INFECTION", INTERVIROLOGY, KARGER, XX, vol. 32, no. 6, 1 January 1991 (1991-01-01), pages 351 - 360, XP009130346, ISSN: 0300-5526
ZEITLIN L ET AL: "Topically applied human recombinant monoclonal IgG-1 antibody and its Fab and F(ab')-2 fragments protect mice from vaginal transmission of HSV-2", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 225, no. 1, 1 January 1996 (1996-01-01), pages 213 - 215, XP002498568, ISSN: 0042-6822
HELDWEIN EKATERINA E ET AL: "Crystal structure of glycoprotein B from herpes simplex virus 1.", SCIENCE (NEW YORK, N.Y.) 14 JUL 2006, vol. 313, no. 5784, 14 July 2006 (2006-07-14), pages 217 - 220, XP002571810, ISSN: 1095-9203
ALMAGRO JUAN C ET AL: "Humanization of antibodies", FRONTIERS IN BIOSCIENCE, FRONTIERS IN BIOSCIENCE, ALBERTSON, NY, US, vol. 13, 1 January 2008 (2008-01-01), pages 1619 - 1633, XP009126790, ISSN: 1093-9946
WARK K L ET AL: "Latest technologies for the enhancement of antibody affinity", ADVANCED DRUG DELIVERY REVIEWS, ELSEVIER BV, AMSTERDAM, NL, vol. 58, no. 5-6, 7 August 2006 (2006-08-07), pages 657 - 670, XP024892147, ISSN: 0169-409X, [retrieved on 20060807]
CHARLES CATHERINE H ET AL: "Prevention of human rhinovirus infection by multivalent Fab molecules directed against ICAM-1", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 47, no. 5, 20 May 2003 (2003-05-20), pages 1503 - 1508, XP009015720, ISSN: 0066-4804, DOI: DOI:10.1128/AAC.47.5.1503-1508.2003
ROLLER D G ET AL: "Structure-function analysis of herpes simplex virus glycoprotein B with fusion-from-without activity", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 382, no. 2, 20 December 2008 (2008-12-20), pages 207 - 216, XP025994150, ISSN: 0042-6822, [retrieved on 20081023]
KOUSOULAS K G ET AL: "Antibody-resistant mutations in cross-reactive and type-specific epitopes of herpes simplex virus 1 glycoprotein B map in separate domains", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 166, no. 2, 1 October 1988 (1988-10-01), pages 423 - 431, XP023049902, ISSN: 0042-6822, [retrieved on 19881001]
BYSTRICKÁ M ET AL: "Monoclonal antibodies to the distinct antigenic sites on glycoproteins C and B and their protective abilities in herpes simplex virus infection", ACTA VIROLOGICA, ACADEMIA PRAGUE, PRAGUE, CS, vol. 41, no. 1, 1 February 1997 (1997-02-01), pages 5 - 12, XP009130340, ISSN: 0001-723X
KUMEL G ET AL: "PASSIVE IMMUNE PROTECTION BY HERPES SIMPLEX VIRUS-SPECIFIC MONOCLONAL ANTIBODIES AND MONOCLONAL ANTIBODY-RESISTANT MUTANTS ALTERED IN PATHOGENICITY", JOURNAL OF VIROLOGY, vol. 56, no. 3, 1985, pages 930 - 937, XP002571807, ISSN: 0022-538X
BENDER FLORENT C ET AL: "Antigenic and mutational analyses of herpes simplex virus glycoprotein B reveal four functional regions", JOURNAL OF VIROLOGY, vol. 81, no. 8, April 2007 (2007-04-01), pages 3827 - 3841, XP002571808, ISSN: 0022-538X
EIS-HÜBINGER A M ET AL: "Anti-glycoprotein B monoclonal antibody protects T cell-depleted mice against herpes simplex virus infection by inhibition of virus replication at the inoculated mucous membranes.", THE JOURNAL OF GENERAL VIROLOGY MAR 1993, vol. 74 ( Pt 3), March 1993 (1993-03-01), pages 379 - 385, XP002571809, ISSN: 0022-1317
EIS-HUEBINGER A M ET AL: "DIFFERENT MECHANISMS OF PROTECTION BY MONOCLONAL AND POLYCLONAL ANTIBODIES DURING THE COURSE OF HERPES SIMPLEX VIRUS INFECTION", INTERVIROLOGY, KARGER, XX, vol. 32, no. 6, 1 January 1991 (1991-01-01), pages 351 - 360, XP009130346, ISSN: 0300-5526
ZEITLIN L ET AL: "Topically applied human recombinant monoclonal IgG-1 antibody and its Fab and F(ab')-2 fragments protect mice from vaginal transmission of HSV-2", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 225, no. 1, 1 January 1996 (1996-01-01), pages 213 - 215, XP002498568, ISSN: 0042-6822
HELDWEIN EKATERINA E ET AL: "Crystal structure of glycoprotein B from herpes simplex virus 1.", SCIENCE (NEW YORK, N.Y.) 14 JUL 2006, vol. 313, no. 5784, 14 July 2006 (2006-07-14), pages 217 - 220, XP002571810, ISSN: 1095-9203
ALMAGRO JUAN C ET AL: "Humanization of antibodies", FRONTIERS IN BIOSCIENCE, FRONTIERS IN BIOSCIENCE, ALBERTSON, NY, US, vol. 13, 1 January 2008 (2008-01-01), pages 1619 - 1633, XP009126790, ISSN: 1093-9946
WARK K L ET AL: "Latest technologies for the enhancement of antibody affinity", ADVANCED DRUG DELIVERY REVIEWS, ELSEVIER BV, AMSTERDAM, NL, vol. 58, no. 5-6, 7 August 2006 (2006-08-07), pages 657 - 670, XP024892147, ISSN: 0169-409X, [retrieved on 20060807]
CHARLES CATHERINE H ET AL: "Prevention of human rhinovirus infection by multivalent Fab molecules directed against ICAM-1", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 47, no. 5, 20 May 2003 (2003-05-20), pages 1503 - 1508, XP009015720, ISSN: 0066-4804, DOI: DOI:10.1128/AAC.47.5.1503-1508.2003
Attorney, Agent or Firm:
LAHRTZ, Fritz (Prinzregentenstrasse 68, München, DE)
Download PDF: