Title:
ANTI HTLV-1 ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2022/065344
Kind Code:
A1
Abstract:
Provided are: an anti-HTLV-1 antibody for preventing the onset of, or treating, diseases caused by HTLV-1 in a person infected by HTLV-1, or preventing infection in a person not infected by HTLV-1; and a drug containing the antibody as an active ingredient. An antibody having the following properties (i)-(vi): (i) the antibody is a monoclonal antibody that recognizes and binds to an envelope protein gp46 of HTLV-1; (ii) the antibody recognizes an epitope comprising an amino acid sequence of amino acid sequence nos. 192-196 of the envelope protein gp46 of HTLV-1 represented by SEQ ID NO: 61; (iii) the binding dissociation constant (KD) with respect to HTLV-1 gp46 peptide nos. 180-204 is 50 nM or less; and (iv) the affinity with respect to six types of gp46 partial peptides in which amino acid sequence nos. 191-196 of the envelope protein gp46 of HTLV-1 represented by SEQ ID NO: 61 are substituted, for each residue respectively, with Ala is equivalent to that with respect to an unsubstituted gp46 partial peptide.
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Inventors:
TANAKA YUETSU (JP)
YOSHIMURA CHIGUSA (JP)
SUGAWARA HAJIME (JP)
YOSHIMURA CHIGUSA (JP)
SUGAWARA HAJIME (JP)
Application Number:
PCT/JP2021/034714
Publication Date:
March 31, 2022
Filing Date:
September 22, 2021
Export Citation:
Assignee:
UNIV OF THE RYUKYUS (JP)
DAIICHI SANKYO CO LTD (JP)
DAIICHI SANKYO CO LTD (JP)
International Classes:
C12N15/13; A61K39/395; A61P27/02; A61P31/14; A61P35/02; C07K16/10; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/63; C12P21/08
Other References:
TANAKA YUETSU, LEE ZENG, HIROSHI SHIRAKI, HISATOSHI SHIDA , HIDEKI TOZAWA: "Identification of a neutralization epitope on the envelope gp46 antigen of human T cell leukemia virus type I and induction of neutralizing antibody by peptide immunization", THE JOURNAL OF IMMUNOLGY, vol. 147, no. 1, 1 January 1991 (1991-01-01), pages 354 - 360, XP000608451, ISSN: 0022-1767
MINEKI SAITO;REIKO TANAKA;HIDEKI FUJII;AKIRA KODAMA;YOSHIAKI TAKAHASHI;TOSHIO MATSUZAKI;HIROSHI TAKASHIMA;YUETSU TANAKA: "The neutralizing function of the anti-HTLV-1 antibody is essential in preventing in vivo transmission of HTLV-1 to human T cells in NOD-SCID/?cnull (NOG) mice", RETROVIROLOGY, vol. 11, no. 1, 28 August 2014 (2014-08-28), GB , pages 74, XP021198629, ISSN: 1742-4690, DOI: 10.1186/s12977-014-0074-z
TANAKA YUETSU, TAKAHASHI YOSHIAKI, TANAKA REIKO, KODAMA AKIRA, FUJII HIDEKI, HASEGAWA ATSUHIKO, KANNAGI MARI, ANSARI AFTAB A., SAI: "Elimination of Human T Cell Leukemia Virus Type-1-Infected Cells by Neutralizing and Antibody-Dependent Cellular Cytotoxicity-Inducing Antibodies Against Human T Cell Leukemia Virus Type-1 Envelope gp46", AIDS RESEARCH AND HUMAN RETROVIRUSES, vol. 30, no. 6, 1 June 2014 (2014-06-01), US , pages 542 - 552, XP055916550, ISSN: 0889-2229, DOI: 10.1089/aid.2013.0214
FUJII HIDEKI, SHIMIZU MAMORU, MIYAGI TAKUYA, KUNIHIRO MARIE, TANAKA REIKO, TAKAHASHI YOSHIAKI, TANAKA YUETSU: "A Potential of an Anti-HTLV-I gp46 Neutralizing Monoclonal Antibody (LAT-27) for Passive Immunization against Both Horizontal and Mother-to-Child Vertical Infection with Human T Cell Leukemia Virus Type-I", VIRUSES, vol. 8, no. 2, 41, 1 January 2016 (2016-01-01), pages 1 - 10, XP055916553, DOI: 10.3390/v8020041
MURAKAMI YUJI, HASEGAWA ATSUHIKO, ANDO SATOMI, TANAKA REIKO, MASUDA TAKAO, TANAKA YUETSU, KANNAGI MARI: "A novel mother-to-child human T-cell leukaemia virus type 1 (HTLV-1) transmission model for investigating the role of maternal anti-HTLV-1 antibodies using orally infected mother rats", JOURNAL OF GENERAL VIROLOGY, vol. 98, no. 4, 1 April 2017 (2017-04-01), pages 835 - 846, XP055916554, ISSN: 0022-1317, DOI: 10.1099/jgv.0.000733
KUO CHIEN-WEN S., MIRSALIOTIS ANTONIS, BRIGHTY DAVID W.: "Antibodies to the Envelope Glycoprotein of Human T Cell Leukemia Virus Type 1 Robustly Activate Cell-Mediated Cytotoxic Responses and Directly Neutralize Viral Infectivity at Multiple Steps of the Entry Process", THE JOURNAL OF IMMUNOLOGY, vol. 187, no. 1, 1 July 2011 (2011-07-01), US , pages 361 - 371, XP055916557, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1100070
KUROKI MIKA, NAKAMURA MINORU, ITOYAMA YASUTO, TANAKA 'YUETSU, LGAKU RINSHO, ZAIDAN SHINKO, ZAIDAN UEHARA: "Identification of new epitopes recognized by human monoclonal antibodies with neutralizing and antibody-dependent cellular cytotoxicity activities specific for human T cell leukemia virus type 1", THE JOURNAL OF IMMUNOLOGY, vol. 149, no. 3, 1 August 1992 (1992-08-01), US , pages 940 - 948, XP055916560, ISSN: 0022-1767
MINEKI SAITO;REIKO TANAKA;HIDEKI FUJII;AKIRA KODAMA;YOSHIAKI TAKAHASHI;TOSHIO MATSUZAKI;HIROSHI TAKASHIMA;YUETSU TANAKA: "The neutralizing function of the anti-HTLV-1 antibody is essential in preventing in vivo transmission of HTLV-1 to human T cells in NOD-SCID/?cnull (NOG) mice", RETROVIROLOGY, vol. 11, no. 1, 28 August 2014 (2014-08-28), GB , pages 74, XP021198629, ISSN: 1742-4690, DOI: 10.1186/s12977-014-0074-z
TANAKA YUETSU, TAKAHASHI YOSHIAKI, TANAKA REIKO, KODAMA AKIRA, FUJII HIDEKI, HASEGAWA ATSUHIKO, KANNAGI MARI, ANSARI AFTAB A., SAI: "Elimination of Human T Cell Leukemia Virus Type-1-Infected Cells by Neutralizing and Antibody-Dependent Cellular Cytotoxicity-Inducing Antibodies Against Human T Cell Leukemia Virus Type-1 Envelope gp46", AIDS RESEARCH AND HUMAN RETROVIRUSES, vol. 30, no. 6, 1 June 2014 (2014-06-01), US , pages 542 - 552, XP055916550, ISSN: 0889-2229, DOI: 10.1089/aid.2013.0214
FUJII HIDEKI, SHIMIZU MAMORU, MIYAGI TAKUYA, KUNIHIRO MARIE, TANAKA REIKO, TAKAHASHI YOSHIAKI, TANAKA YUETSU: "A Potential of an Anti-HTLV-I gp46 Neutralizing Monoclonal Antibody (LAT-27) for Passive Immunization against Both Horizontal and Mother-to-Child Vertical Infection with Human T Cell Leukemia Virus Type-I", VIRUSES, vol. 8, no. 2, 41, 1 January 2016 (2016-01-01), pages 1 - 10, XP055916553, DOI: 10.3390/v8020041
MURAKAMI YUJI, HASEGAWA ATSUHIKO, ANDO SATOMI, TANAKA REIKO, MASUDA TAKAO, TANAKA YUETSU, KANNAGI MARI: "A novel mother-to-child human T-cell leukaemia virus type 1 (HTLV-1) transmission model for investigating the role of maternal anti-HTLV-1 antibodies using orally infected mother rats", JOURNAL OF GENERAL VIROLOGY, vol. 98, no. 4, 1 April 2017 (2017-04-01), pages 835 - 846, XP055916554, ISSN: 0022-1317, DOI: 10.1099/jgv.0.000733
KUO CHIEN-WEN S., MIRSALIOTIS ANTONIS, BRIGHTY DAVID W.: "Antibodies to the Envelope Glycoprotein of Human T Cell Leukemia Virus Type 1 Robustly Activate Cell-Mediated Cytotoxic Responses and Directly Neutralize Viral Infectivity at Multiple Steps of the Entry Process", THE JOURNAL OF IMMUNOLOGY, vol. 187, no. 1, 1 July 2011 (2011-07-01), US , pages 361 - 371, XP055916557, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1100070
KUROKI MIKA, NAKAMURA MINORU, ITOYAMA YASUTO, TANAKA 'YUETSU, LGAKU RINSHO, ZAIDAN SHINKO, ZAIDAN UEHARA: "Identification of new epitopes recognized by human monoclonal antibodies with neutralizing and antibody-dependent cellular cytotoxicity activities specific for human T cell leukemia virus type 1", THE JOURNAL OF IMMUNOLOGY, vol. 149, no. 3, 1 August 1992 (1992-08-01), US , pages 940 - 948, XP055916560, ISSN: 0022-1767
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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