Title:
ANTI-HUMAN CD3 ANTIBODY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/036326
Kind Code:
A1
Abstract:
Provided are an anti-human CD3 antibody and the use thereof. Specifically, provided are an antibody specifically binding to human CD3 or an antigen binding fragment thereof, a multi-specific antigen binding molecule, an isolated nucleic acid molecule, a vector, a cell and an immune effector cell thereof, a method for preparing the antibody or the antigen binding fragment thereof, the multi-specific antigen binding molecule and the immune effector cell, a pharmaceutical composition, the pharmaceutical use and a method for treating diseases.
Inventors:
WANG QIONG (CN)
FU YAYUAN (CN)
WEI PEIPEI (CN)
CAO ZHUOXIAO (CN)
TANG RENHONG (CN)
REN JINSHENG (CN)
FU YAYUAN (CN)
WEI PEIPEI (CN)
CAO ZHUOXIAO (CN)
TANG RENHONG (CN)
REN JINSHENG (CN)
Application Number:
PCT/CN2022/118334
Publication Date:
March 16, 2023
Filing Date:
September 13, 2022
Export Citation:
Assignee:
JIANGSU SIMCERE PHARM CO LTD (CN)
International Classes:
C07K16/28; A61K39/395; A61P35/00; C12N5/10; C12N15/13; C12N15/63
Domestic Patent References:
| WO2019034580A1 | 2019-02-21 |
Foreign References:
| CN110691789A | 2020-01-14 | |||
| CN104098698A | 2014-10-15 | |||
| CN107889492A | 2018-04-06 | |||
| CN111247171A | 2020-06-05 | |||
| US20180112000A1 | 2018-04-26 | |||
| US4816567A | 1989-03-28 | |||
| EP2101823B1 | 2016-11-23 |
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ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 10
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METHODS IN ENZYMOLOGY, vol. 220
ROQUE ET AL., BIOTECHNOL. PROG., vol. 20, 2004, pages 639 - 654
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883
POLJAK R.J. ET AL., STRUCTURE, vol. 113, 1994, pages 1121 - 1123
HOLLIGER P. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
ALFTHAN ET AL., PROTEIN ENG, vol. 8, 1995, pages 725 - 731
CHOI ET AL., EUR. J. IMMUNOL., vol. 31, 2001, pages 94 - 106
HU ET AL., CANCER RES, vol. 56, 1996, pages 3055 - 3061
KIPRIYANOV ET AL., J. MOL. BIOL., vol. 293, 1999, pages 41 - 56
ROOVERS ET AL., CANCER IMMUNOL, 2001
MORRISON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 6851 - 6855
KINDT ET AL.: "Kuby Immunology", 2007, W.H.FREEMAN AND CO.
KABAT ET AL., J. BIOL. CHEM., vol. 252, 1977, pages 6609 - 6616
KABAT ET AL.: "Sequences of proteins of immunological interest", UNITED STATES DEPARTMENT OF HEALTH AND HUMAN SERVICES, 1991
CHOTHIA ET AL., J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
AL-LAZIKANI B. ET AL., J. MOL. BIOL., vol. 273, 1997, pages 927 - 948
MACCALLUM ET AL., J. MOL. BIOL., vol. 262, 1996, pages 732 - 745
MARTIN, MOL. IMMUNOL., vol. 45, 2008, pages 3832 - 3839
LEFRANC M.P. ET AL., DEV. COMP. IMMUNOL., vol. 27, 2003, pages 55 - 77
HONEGGERPLUCKTHUN, J. MOL. BIOL., vol. 309, 2001, pages 657 - 670
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, NATIONAL INSTITUTES OF HEALTH
NEEDLEMAWUNSCH, J. MOL. BIOL., vol. 48, 1970, pages 444 - 453
E. MEYERSW. MILLER, CABIOS, vol. 4, 1989, pages 11 - 17
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 10
ALTSCHUL ET AL., NUCLEIC ACIDS RES, vol. 25, 1997, pages 3389 - 3402
STADLER ET AL., NATURE MEDICINE, 12 June 2017 (2017-06-12)
SAMBROOK, J.FRITSCH, E. F.MANIATIS, T.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
METHODS IN ENZYMOLOGY, vol. 220
Attorney, Agent or Firm:
INSIGHT INTELLECTUAL PROPERTY LIMITED (CN)
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