ANTI-HUMAN CD52 IMMUNOGLOBULINS

Title:

ANTI-HUMAN CD52 IMMUNOGLOBULINS

Document Type and Number:

WIPO Patent Application WO/2010/132659

Kind Code:

A3

Abstract:

The present invention relates to humanized immunoglobulins, mouse monoclonal antibodies and chimeric antibodies that have binding specificity for human CD52. The present invention further relates to a humanized immunoglobulin light chain and a humanized immunoglobulin heavy chain. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a humanized immunoglobulin or immunoglobulin light chain or heavy chain, and to a method of preparing a humanized immunoglobulin. The humanized immunoglobulins can be used in therapeutic applications to treat, for example, autoimmune disease, cancer, non-Hodgkin's lymphoma, multiple sclerosis and chronic lymphocytic leukemia.

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Inventors:

ROBERTS BRUCE L (US)
SHANKARA SRINIVAS (US)
BRONDYK WILLIAM HAROLD (US)
SIDERS WILLIAM M (US)

Application Number:

PCT/US2010/034704

Publication Date:

January 06, 2011

Filing Date:

May 13, 2010

Export Citation:

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Assignee:

GENZYME CORP (US)
ROBERTS BRUCE L (US)
SHANKARA SRINIVAS (US)
BRONDYK WILLIAM HAROLD (US)
SIDERS WILLIAM M (US)

International Classes:

C12P21/08; A61K39/00; A61K39/395

Foreign References:

US20060204496A1	2006-09-14
US20070253948A1	2007-11-01
US20070178098A1	2007-08-02
US20020132983A1	2002-09-19
US6054561A	2000-04-25

Other References: